A materials-science perspective on tackling COVID-19

Cell-Membrane-Mimicking Nanodecoys against Infectious Diseases

(2020) Lang Rao et al.   ACS Nano

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Connecting With Patients—The Missing Links

(2020) Lisa Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient

(2020) Sean Wei Xiang Ong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Responding to Covid-19 — A Once-in-a-Century Pandemic?

(2020) Bill Gates   NEW ENGLAND JOURNAL OF MEDICINE

CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)

(2020) Michael Chung et al.   RADIOLOGY

Toward a universal flu vaccine

(2020) Susanne Herold et al.   SCIENCE

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Modified cyclodextrins as broad-spectrum antivirals

(2020) Samuel T. Jones et al.   Science Advances

Flexible Nanoporous Template for the Design and Development of Reusable Anti-COVID-19 Hydrophobic Face Masks

(2020) Nazek El-Atab et al.   ACS Nano

Reusable and Recyclable Graphene Masks with Outstanding Superhydrophobic and Photothermal Performances

(2020) Hong Zhong et al.   ACS Nano

Can N95 Respirators Be Reused after Disinfection? How Many Times?

(2020) Lei Liao et al.   ACS Nano

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

(2020) Daniel Wrapp et al.   CELL

Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography

(2020) Kang Zhang et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes

(2020) Ammar D. Elmezayen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

CRISPR–Cas12-based detection of SARS-CoV-2

(2020) James P. Broughton et al.   NATURE BIOTECHNOLOGY

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

(2020) Daniel Lauster et al.   Nature Nanotechnology

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT

(2020) Lin Li et al.   RADIOLOGY

Time to pull together

(2020) H. Holden Thorp   SCIENCE

Rapid implementation of mobile technology for real-time epidemiology of COVID-19

(2020) David A. Drew et al.   SCIENCE

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

(2020) Yan Wu et al.   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

High-performance particulate matter including nanoscale particle removal by a self-powered air filter

(2020) Guo-Hao Zhang et al.   Nature Communications

COVID-19, ECMO, and lymphopenia: a word of caution

(2020) Brandon Michael Henry   Lancet Respiratory Medicine

Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics

(2020) Roy Pattipeiluhu et al.   ACS Central Science

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation

(2020) Flavio Dormont et al.   Science Advances

Magnetic Ionic Liquids as Solvents for RNA Extraction and Preservation

(2020) Chenghui Zhu et al.   ACS Omega

NIR‐II Chemiluminescence Molecular Sensor for In Vivo High‐Contrast Inflammation Imaging

(2020) Yanling Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

(2020) Qiangzhe Zhang et al.   NANO LETTERS

Dexamethasone nanomedicines for COVID-19

(2020) Twan Lammers et al.   Nature Nanotechnology

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS‐CoV‐2 and Other Respiratory Viruses

(2020) Ming Wang et al.   Small

Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

(2020) Benhao Li et al.   Nature Communications

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

(2020) John E. Blume et al.   Nature Communications

Extracorporeal Membrane Oxygenation for Patients With COVID-19 in Severe Respiratory Failure

(2020) Asif K. Mustafa et al.   JAMA Surgery

The global rise of 3D printing during the COVID-19 pandemic

(2020) Yu Ying Clarrisa Choong et al.   Nature Reviews Materials

Face Masks in the New COVID-19 Normal: Materials, Testing, and Perspectives

(2020) Ming Hui Chua et al.   Research

Antimicrobial Photodynamic Therapy in the Control of COVID-19

(2020) Adelaide Almeida et al.   Antibiotics-Basel

Scale-free vertical tracking microscopy

(2020) Deepak Krishnamurthy et al.   NATURE METHODS

NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

(2020) Lingfei Lu et al.   Nature Communications

BiteOscope, an open platform to study mosquito biting behavior

(2020) Felix JH Hol et al.   eLife

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Electrospun Polyimide/Metal-Organic Framework Nanofibrous Membrane with Superior Thermal Stability for Efficient PM2.5 Capture

(2019) Zhimin Hao et al.   ACS Applied Materials & Interfaces

Fabrication of polystyrene-encapsulated magnetic iron oxide nanoparticles via batch and microfluidic-assisted production

(2019) Chiara Taddei et al.   COLLOID AND POLYMER SCIENCE

Material design for lymph node drug delivery

(2019) Alex Schudel et al.   Nature Reviews Materials

Metal-organic frameworks with photocatalytic bactericidal activity for integrated air cleaning

(2019) Ping Li et al.   Nature Communications

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

(2019) Yeteng Zhong et al.   NATURE BIOTECHNOLOGY

SHERLOCK: nucleic acid detection with CRISPR nucleases

(2019) Max J. Kellner et al.   Nature Protocols

Engineered materials for organoid systems

(2019) Michael J. Kratochvil et al.   Nature Reviews Materials

A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat

(2019) Yiran Yang et al.   NATURE BIOTECHNOLOGY

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

(2019) Paul S. Kwon et al.   Nature Chemistry

Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection

(2019) Ankan Dutta Chowdhury et al.   Nature Communications

Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation

(2019) Mythreyi Unni et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

(2019) Kevin J. McHugh et al.   Science Translational Medicine

Hierarchical Metal–Organic Framework-Assembled Membrane Filter for Efficient Removal of Particulate Matter

(2018) Won-Tae Koo et al.   ACS Applied Materials & Interfaces

Multivalent Flexible Nanogels Exhibit Broad-Spectrum Antiviral Activity by Blocking Virus Entry

(2018) Pradip Dey et al.   ACS Nano

Fe-Au Nanoparticle-Coupling for Ultrasensitive Detections of Circulating Tumor DNA

(2018) Ping Hu et al.   ADVANCED MATERIALS

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

(2018) Chris Soon Heng Tan et al.   SCIENCE

Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management

(2018) Can Yang Zhang et al.   ADVANCED MATERIALS

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

A novel scavenging tool for cancer biomarker discovery based on the blood-circulating nanoparticle protein corona

(2018) Marilena Hadjidemetriou et al.   BIOMATERIALS

A Biomimetic Nanodecoy Traps Zika Virus To Prevent Viral Infection and Fetal Microcephaly Development

(2018) Lang Rao et al.   NANO LETTERS

Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase

(2017) Nidhi Kaushik et al.   JOURNAL OF VIROLOGY

A Light Responsive Nanoparticle-Based Delivery System Using Pheophorbide A Graft Polyethylenimine for Dendritic Cell-Based Cancer Immunotherapy

(2017) Chuangnian Zhang et al.   MOLECULAR PHARMACEUTICS

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

(2017) Yang Liu et al.   NATURE

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

(2017) Valeria Cagno et al.   NATURE MATERIALS

Diagnosis of Zika virus infection on a nanotechnology platform

(2017) Bo Zhang et al.   NATURE MEDICINE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Very High Concentration Solubility and Long-Term Stability of DNA in an Ammonium-Based Ionic Liquid: A Suitable Medium for Nucleic Acid Packaging and Preservation

(2017) Nripat Singh et al.   ACS Sustainable Chemistry & Engineering

Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers

(2017) Maria Sánchez-Purrà et al.   ACS Infectious Diseases

Wearable, Flexible, and Multifunctional Healthcare Device with an ISFET Chemical Sensor for Simultaneous Sweat pH and Skin Temperature Monitoring

(2017) Shogo Nakata et al.   ACS Sensors

Hand-powered ultralow-cost paper centrifuge

(2017) M. Saad Bhamla et al.   Nature Biomedical Engineering

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

Three decades of nanopore sequencing

(2016) David Deamer et al.   NATURE BIOTECHNOLOGY

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

(2016) Hyunjae Lee et al.   Nature Nanotechnology

The 3.8 A resolution cryo-EM structure of Zika virus

(2016) D. Sirohi et al.   SCIENCE

A Primer to Single-Particle Cryo-Electron Microscopy

(2015) Yifan Cheng et al.   CELL

Broad-spectrum antivirals against viral fusion

(2015) Frederic Vigant et al.   NATURE REVIEWS MICROBIOLOGY

The Next Epidemic — Lessons from Ebola

(2015) Bill Gates   NEW ENGLAND JOURNAL OF MEDICINE

Virus-mimetic nanovesicles as a versatile antigen-delivery system

(2015) Pengfei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic electrostatic separator based on pre-charged droplets

(2015) Lang Rao et al.   SENSORS AND ACTUATORS B-CHEMICAL

Visualizing real-time influenza virus infection, transmission and protection in ferrets

(2015) Erik A. Karlsson et al.   Nature Communications

Transparent air filter for high-efficiency PM2.5 capture

(2015) Chong Liu et al.   Nature Communications

Microfluidic Isolation of Nucleic Acids

(2014) Sarah J. Reinholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform

(2014) Martin D. Baaske et al.   Nature Nanotechnology

A single-stranded architecture for cotranscriptional folding of RNA nanostructures

(2014) C. Geary et al.   SCIENCE

Visualizing the replication of respiratory syncytial virus in cells and in living mice

(2014) Marie-Anne Rameix-Welti et al.   Nature Communications

Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies

(2014) David B Tulman et al.   BMC Anesthesiology

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Routes of influenza transmission

(2013) Ben Killingley et al.   Influenza and Other Respiratory Viruses

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

The role of mutational robustness in RNA virus evolution

(2013) Adam S. Lauring et al.   NATURE REVIEWS MICROBIOLOGY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Visualizing influenza virus infection in living mice

(2013) Weiqi Pan et al.   Nature Communications

Aerosol transmission is an important mode of influenza A virus spread

(2013) Benjamin J. Cowling et al.   Nature Communications

Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

(2012) Lauren Willis et al.   LUNG

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bioelectronics: The bionic material

(2012) Charles Schmidt   NATURE

Oxford Nanopore announcement sets sequencing sector abuzz

(2012) Michael Eisenstein   NATURE BIOTECHNOLOGY

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics

(2011) B. Scott Ferguson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly uniform and reproducible surface-enhanced Raman scattering from DNA-tailorable nanoparticles with 1-nm interior gap

(2011) Dong-Kwon Lim et al.   Nature Nanotechnology

Extracorporeal Membrane Oxygenation for ARDS in Adults

(2011) Daniel Brodie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Nanofiber Assembly by Rotary Jet-Spinning

(2010) Mohammad Reza Badrossamay et al.   NANO LETTERS

Polymeric Materials for Gene Delivery and DNA Vaccination

(2008) David N. Nguyen et al.   ADVANCED MATERIALS

Virion disruption by ozone-mediated reactive oxygen species

(2008) Byron K. Murray et al.   JOURNAL OF VIROLOGICAL METHODS

Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering

(2008) Marco Cammarata et al.   NATURE METHODS