Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

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Reducing mortality from 2019-nCoV: host-directed therapies should be an option

(2020) Alimuddin Zumla et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Clinical Characteristics of Coronavirus Disease 2019 in China

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Pathological findings of COVID-19 associated with acute respiratory distress syndrome

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Severe Acute Respiratory Syndrome

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The Middle East Respiratory Syndrome (MERS)

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CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

High levels of circulating GM-CSF+CD4+ T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study

(2018) Huihuang Huang et al.   Cellular & Molecular Immunology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes

(2016) Caroline Stienne et al.   IMMUNITY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Clinical experience of IL-6 blockade in rheumatic diseases—Implications on IL-6 biology and disease pathogenesis

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Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection

(2013) Christian Drosten et al.   LANCET INFECTIOUS DISEASES

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

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Into the Eye of the Cytokine Storm

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

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Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

Revisiting Immune Exhaustion During HIV Infection

(2010) Alka Khaitan et al.   Current HIV/AIDS Reports

The significance of OX40 and OX40L to T-cell biology and immune disease

(2009) Michael Croft et al.   IMMUNOLOGICAL REVIEWS

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

(2009) B. Rockx et al.   JOURNAL OF VIROLOGY