Polyphenols in the Mediterranean Diet: From Dietary Sources to microRNA Modulation

Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: The protective role of hesperidin

(2020) Hebatullah S. Helmy et al.   TOXICOLOGY

Honey and Its Phenolic Compounds as an Effective Natural Medicine for Cardiovascular Diseases in Humans?

(2020) Beata Olas   Nutrients

Kaempferol Regulates miR-15b/Bcl-2/TLR4 to Alleviate OGD-Induced Injury in H9c2 Cells

(2020) Linping Li et al.   International Heart Journal

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

(2020) Guendalina Zuccari et al.   Applied Sciences-Basel

Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role

(2020) Stefania D’Adamo et al.   Cells

Naringenin Inhibits Cell Migration, Invasion, and Tumor Growth by Regulating circFOXM1/miR-3619-5p/SPAG5 Axis in Lung Cancer

(2020) Zhaofeng Tan et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Apigenin attenuates TGF-β1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway

(2020) Feng Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?

(2020) Silvana Alfei et al.   Antioxidants

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

(2020) Paolo Bellavite et al.   Antioxidants

Hesperidin administration suppresses the proliferation of lung cancer cells by promoting apoptosis via targeting the miR‑132/ZEB2 signalling pathway

(2020) Song Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

(2020) Waqas Alam et al.   MOLECULES

Perspective: The Potential Effects of Naringenin in COVID-19

(2020) Ricardo Wesley Alberca et al.   Frontiers in Immunology

Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms

(2020) Azher Arafah et al.   Plants-Basel

Supplementation with Hydroxytyrosol and Punicalagin Improves Early Atherosclerosis Markers Involved in the Asymptomatic Phase of Atherosclerosis in the Adult Population: A Randomized, Placebo-Controlled, Crossover Trial

(2019) Rebeca Quirós-Fernández et al.   Nutrients

The Effect of Olive Leaf Extract on Upper Respiratory Illness in High School Athletes: A Randomised Control Trial

(2019) Vaughan Somerville et al.   Nutrients

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

(2019) Marziyeh Hajialyani et al.   MOLECULES

Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better

(2019) Tiziana Larussa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation

(2019) Gabriele Carullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a

(2019) Rui Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

(2019) Karković Marković et al.   MOLECULES

Kaempferol promotes proliferation, migration and differentiation of MC3T3-E1 cells via up-regulation of microRNA-101

(2019) Yang Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b

(2019) PeiPei Wang et al.   MEDICAL SCIENCE MONITOR

Kaempferol protects lipopolysaccharide-induced inflammatory injury in human aortic endothelial cells (HAECs) by regulation of miR-203

(2019) Shuxian Cui et al.   BIOMEDICINE & PHARMACOTHERAPY

Over 3 decades of research on dietary flavonoid antioxidants and cancer prevention: What have we achieved?

(2019) Hajara H. Alfa et al.   PHYTOCHEMISTRY REVIEWS

The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health

(2019) Yala Stevens et al.   Nutrients

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

(2019) yanping zhou et al.   CHEMISTRY & BIODIVERSITY

Recent progress regarding kaempferol for the treatment of various diseases (Review)

(2019) Jie Ren et al.   Experimental and Therapeutic Medicine

Naringenin Increases Insulin Sensitivity and Metabolic Rate: A Case Study

(2019) Navya Murugesan et al.   JOURNAL OF MEDICINAL FOOD

The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

(2019) Sok Kuan Wong et al.   Drug Design Development and Therapy

Cancer and Mediterranean Diet: A Review

(2019) Mentella et al.   Nutrients

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

(2019) Nouri et al.   Biomolecules

Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis

(2019) Roberto Cannataro et al.   Antioxidants

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

(2019) Erika Cione et al.   MOLECULES

Chronic administration of ellagic acid improved the cognition in middle-aged overweight men

(2018) Ying Liu et al.   Applied Physiology Nutrition and Metabolism

Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis

(2018) Ai-Mei Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I–III degree hemorroidal disease: a double-blind multicenter prospective comparative study

(2018) Italo Corsale et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Improving in vivo conversion of oleuropein into hydroxytyrosol by oral granules containing probiotic Lactobacillus plantarum 299v and an Olea europaea standardized extract

(2018) Maria Aponte et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples

(2018) Maren Vollmer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial

(2018) Fatemeh Homayouni et al.   PHYTOTHERAPY RESEARCH

A Pharmacological Update of Ellagic Acid

(2018) José-Luis Ríos et al.   PLANTA MEDICA

The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity

(2018) Daniela Gentile et al.   PLoS One

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

(2018) A. Cortés-Martín et al.   Food & Function

Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells

(2018) Xue Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of naringin metabolites mediated by human intestinal microbes with stable isotope-labeling method and UFLC-Q-TOF-MS/MS

(2018) Taobin Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Combating oxidative stress disorders with citrus flavonoid: Naringenin

(2018) Nurul Hannim Zaidun et al.   LIFE SCIENCES

Polyphenols regulating microRNAs and inflammation biomarkers in obesity

(2018) Telma A.F. Corrêa et al.   NUTRITION

Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of miR-26a-5p via inhibiting TLR4/NF-κB pathway in human endothelial cells

(2018) Xiaoming Zhong et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

(2018) Ruthvika Joshi et al.   LIFE SCIENCES

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway

(2018) Xiaoqin Ding et al.   BIOMEDICINE & PHARMACOTHERAPY

Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials

(2017) M Dinu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

(2017) Whasun Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d

(2017) Ting Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anti-inflammatory effects of polyphenols in arthritis

(2017) Francesca Oliviero et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy

(2017) Fang Li et al.   Oxidative Medicine and Cellular Longevity

miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway

(2017) Yi Wan et al.   TUMOR BIOLOGY

Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

(2017) Dharambir Kashyap et al.   Journal of Functional Foods

Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence

(2017) Colin D. Kay et al.   Annual Review of Food Science and Technology

Oleuropein represses the radiation resistance of ovarian cancer by inhibiting hypoxia and microRNA-299-targetted heparanase expression

(2017) Yubai Xing et al.   Food & Function

Effects of Pomegranate Juice Supplementation on Oxidative Stress Biomarkers Following Weightlifting Exercise

(2017) Achraf Ammar et al.   Nutrients

Enantioselective Modulatory Effects of Naringenin  Enantiomers on the Expression Levels of miR‐17‐3p  Involved in Endogenous Antioxidant Defenses

(2017) Valeria Curti et al.   Nutrients

Could Pomegranate Juice Help in the Control of Inflammatory Diseases?

(2017) Francesca Danesi et al.   Nutrients

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

(2017) Ai-Mei Gao et al.   Oncotarget

Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?

(2017) Carmela Santangelo et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Hydroxytyrosol supplementation increases vitamin C levels in vivo . A human volunteer trial

(2017) Eduardo Lopez-Huertas et al.   Redox Biology

The evolutionary origin of plant and animal microRNAs

(2017) Yehu Moran et al.   Nature Ecology & Evolution

Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals

(2016) Bouke N Salden et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study

(2016) Nikolaos Lemonakis et al.   BIOMEDICAL CHROMATOGRAPHY

Insights Into Effects of Ellagic Acid on the Nervous System: A Mini Review

(2016) Touqeer Ahmed et al.   CURRENT PHARMACEUTICAL DESIGN

Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco-2 Cell Monolayers

(2016) Xin Mao et al.   Evidence-based Complementary and Alternative Medicine

Pharmacokinetic properties and drug interactions of apigenin, a natural flavone

(2016) Ding Tang et al.   Expert Opinion on Drug Metabolism & Toxicology

Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223

(2016) Long-Bao Shi et al.   GENE

Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway

(2016) Min Li et al.   INFLAMMATION

Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women

(2016) Berdine R. Martin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Apigenin inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP-9

(2016) Xin-Jun Chen et al.   Molecular Medicine Reports

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial

(2016) Jun J. Mao et al.   PHYTOMEDICINE

Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms

(2016) Inhae Kang et al.   Advances in Nutrition

Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy

(2016) Ning Yan et al.   Journal of Diabetes Research

Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: a randomized, controlled, crossover trial

(2015) Véronique Habauzit et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Mediterranean Diet, its Components, and Cardiovascular Disease

(2015) R. Jay Widmer et al.   AMERICAN JOURNAL OF MEDICINE

Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial

(2015) Stacey Lockyer et al.   BRITISH JOURNAL OF NUTRITION

Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

(2015) Raul Zamora-Ros et al.   EUROPEAN JOURNAL OF NUTRITION

A defence-related Olea europaea β-glucosidase hydrolyses and activates oleuropein into a potent protein cross-linking agent

(2015) Konstantinos Koudounas et al.   JOURNAL OF EXPERIMENTAL BOTANY

Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression

(2015) Kwangho Kim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

Cancer prevention and therapy through the modulation of the tumor microenvironment

(2015) Stephanie C. Casey et al.   SEMINARS IN CANCER BIOLOGY

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

(2015) Antonio González-Sarrías et al.   Journal of Functional Foods

Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers

(2015) Zhaoping Li et al.   Food & Function

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

(2014) Barbara Barbaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

(2014) Francisco A. Tomás-Barberán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cruciferous Vegetables Have Variable Effects on Biomarkers of Systemic Inflammation in a Randomized Controlled Trial in Healthy Young Adults

(2014) Sandi L. Navarro et al.   JOURNAL OF NUTRITION

Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches

(2014) Juana I. Mosele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels

(2014) Chikako Shibata et al.   VIROLOGY

Mediterranean Diet and Diabetes: Prevention and Treatment

(2014) Michael Georgoulis et al.   Nutrients

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

(2014) M. Ashraful Alam et al.   Advances in Nutrition

miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo

(2013) Mrinmay Chakrabarti et al.   EXPERIMENTAL CELL RESEARCH

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaeaL.) leaf extract

(2013) Martin de Bock et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Techniques for Analysis of Plant Phenolic Compounds

(2013) Ali Khoddami et al.   MOLECULES

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice

(2013) Motoko Ohno et al.   Scientific Reports

Biopharmaceutics classification and intestinal absorption study of apigenin

(2012) Jianjun Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Phytochemicals and their impact on adipose tissue inflammation and diabetes

(2012) Andreas Leiherer et al.   VASCULAR PHARMACOLOGY

Bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria

(2012) M. M. Santos et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study

(2011) Suzanna M Zick et al.   BMC Complementary and Alternative Medicine

Effects of Flavonoids and other Polyphenols on Inflammation

(2011) R. González et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Molecular Basis for the Pharmacological Activity of Anthocyans

(2011) R. Domitrovic   CURRENT MEDICINAL CHEMISTRY

Hydrophilic antioxidants of virgin olive oil. Part 2: Biosynthesis and biotransformation of phenolic compounds in virgin olive oil as affected by agronomic and processing factors

(2011) Milad El Riachy et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Hesperidin and hesperetin membrane interaction: Understanding the role of 7-O-glycoside moiety in flavonoids

(2010) Julián Londoño-Londoño et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples

(2010) W. Brand et al.   DRUG METABOLISM AND DISPOSITION

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(2010) Miguel Lopez-Lazaro   MOLECULAR MEDICINE

The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers

(2010) Walter Brand et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

(2009) Avantika Barve et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats

(2009) Young-Ah Cho et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Phenylpropanoid Biosynthesis

(2009) Thomas Vogt   Molecular Plant

Enhanced bioavailability of verapamil after oral administration with hesperidin in rats

(2008) Yong-Ji Piao et al.   ARCHIVES OF PHARMACAL RESEARCH