Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better

Olive oil industry by-products. Effects of a polyphenol-RICH extract on the metabolome and response to inflammation in cultured intestinal cell

(2018) Mattia Di Nunzio et al.   FOOD RESEARCH INTERNATIONAL

Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion

(2018) Hong‑Xu Jin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle

(2018) Ahmad Alkhatib et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential Health Benefits of Olive Oil and Plant Polyphenols

(2018) Monika Gorzynik-Debicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-Inflammatory Local Effect of Hydroxytyrosol Combined with Pectin-Alginate and Olive Oil on Trinitrobenzene Sulfonic Acid-Induced Colitis in Wistar Rats

(2018) A. Voltes et al.   JOURNAL OF INVESTIGATIVE SURGERY

The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat

(2018) C. Conde et al.   NUTRITIONAL NEUROSCIENCE

Influence of a diet enriched with virgin olive oil or butter on mouse gut microbiota and its correlation to physiological and biochemical parameters related to metabolic syndrome

(2018) Isabel Prieto et al.   PLoS One

Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches

(2018) Sajid Ur Rahman et al.   INFLAMMOPHARMACOLOGY

Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells

(2018) Gessica Serra et al.   Redox Biology

Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice

(2018) Giovanni Enrico Lombardo et al.   Frontiers in Endocrinology

Virgin olive oil and its phenol fraction modulate monocyte/macrophage functionality: a potential therapeutic strategy in the treatment of systemic lupus erythematosus

(2018) Marina Aparicio-Soto et al.   BRITISH JOURNAL OF NUTRITION

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

(2018) Monica Deiana et al.   Food & Function

Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1β-activated synovial fibroblasts

(2018) María Ángeles Rosillo et al.   BRITISH JOURNAL OF NUTRITION

Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats

(2018) Kubra Koc et al.   DRUG AND CHEMICAL TOXICOLOGY

Cross-Sectional Analysis of Overall Dietary Intake and Mediterranean Dietary Pattern in Patients with Crohn’s Disease

(2018) Lorian Taylor et al.   Nutrients

The Effect of Chronic Inflammation and Oxidative and Endoplasmic Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy

(2018) Michalina Alicka et al.   Stem Cells International

Soft-MS and Computational Mapping of Oleuropein

(2017) Luigi Gentile et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioactivity of Olive Oil Phenols in Neuroprotection

(2017) Cristina Angeloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of the Senescence-Associated Inflammatory Phenotype in Human Fibroblasts by Olive Phenols

(2017) Beatrice Menicacci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant Effect of Natural Table Olives Phenolic Extract Against Oxidative Stress and Membrane Damage in Enterocyte-Like Cells

(2017) Gabriele Serreli et al.   JOURNAL OF FOOD SCIENCE

Olive tree (Olea europaea L.) leaf as a waste by-product of table olive and olive oil industry: a review

(2017) Selin Şahin et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation

(2017) Teresa Vezza et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Olive Polyphenols and the Metabolic Syndrome

(2017) et al.   MOLECULES

Changes in Gut Microbiota Linked to a Reduction in Systolic Blood Pressure in Spontaneously Hypertensive Rats Fed an Extra Virgin Olive Oil-Enriched Diet

(2017) Marina Hidalgo et al.   PLANT FOODS FOR HUMAN NUTRITION

Protection by extra virgin olive oil against oxidative stress in vitro and in vivo. Chemical and biological studies on the health benefits due to a major component of the Mediterranean diet

(2017) Miriam Rossi et al.   PLoS One

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

(2017) Wafa Zeriouh et al.   PLoS One

Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes

(2017) Yangyang R. Yu et al.   Seminars in Pediatric Surgery

Potential role of nutraceutical compounds in inflammatory bowel disease

(2017) Tiziana Larussa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

(2017) Ali Salaritabar et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982

(2017) Maria Luisa Castejón et al.   Food & Function

Oleuropein Decreases Cyclooxygenase-2 and Interleukin-17 Expression and Attenuates Inflammatory Damage in Colonic Samples from Ulcerative Colitis Patients

(2017) Tiziana Larussa et al.   Nutrients

The Protective Effects of Extra Virgin Olive Oil on Immune-mediated Inflammatory Responses

(2017) Rosa Casas et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?

(2017) Carmela Santangelo et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): Rationale, methods, and baseline characteristics

(2016) Javier Delgado-Lista et al.   AMERICAN HEART JOURNAL

Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases

(2016) Giovanni Tomasello et al.   BIOMEDICAL PAPERS-OLOMOUC

Phytoestrogen (+)-pinoresinol exerts antitumor activity in breast cancer cells with different oestrogen receptor statuses

(2016) Alicia López-Biedma et al.   BMC Complementary and Alternative Medicine

Transdermal anti-inflammatory activity of bilayer film containing olive compound hydroxytyrosol: physical assessment, in vivo dermal safety and efficacy study in Freund’s adjuvant-induced arthritic rat model

(2016) Shiow-Fern Ng et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial

(2016) Stacey Lockyer et al.   EUROPEAN JOURNAL OF NUTRITION

Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease

(2016) J. Schulberg et al.   INTERNAL MEDICINE JOURNAL

Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans

(2016) Stefania Rigacci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds

(2016) Lisa Parkinson et al.   MOLECULES

Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells

(2016) Andrea Coccia et al.   ONCOLOGY REPORTS

Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients-A Pilot Study

(2016) Andrea Čabarkapa et al.   PHYTOTHERAPY RESEARCH

Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function

(2016) Sandra Martín-Peláez et al.   Nutrients

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

(2016) Anna Boss et al.   Nutrients

Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial

(2015) Stacey Lockyer et al.   BRITISH JOURNAL OF NUTRITION

Nutritional therapy in inflammatory bowel disease

(2015) Chen Sarbagili-Shabat et al.   CURRENT OPINION IN GASTROENTEROLOGY

The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease

(2015) Mohammad Farzaei et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: implications of human gut microbiota

(2015) Sandra Martín-Peláez et al.   EUROPEAN JOURNAL OF NUTRITION

Phenolic compounds in olive leaves: Analytical determination, biotic and abiotic influence, and health benefits

(2015) Nassima Talhaoui et al.   FOOD RESEARCH INTERNATIONAL

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial

(2015) Álvaro Hernáez et al.   JOURNAL OF NUTRITION

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

(2015) S. Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells

(2015) Eri Muto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis

(2015) María Angeles Rosillo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation

(2015) Erika Terzuoli et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice

(2015) Elisa Giner et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Health Benefits of the Mediterranean Diet

(2014) Efthymios Gotsis et al.   ANGIOLOGY

Olive Oil Polyphenols Enhance High-Density Lipoprotein Function in Humans

(2014) Álvaro Hernáez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

(2014) Ioanna Andreadou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

(2014) María Ángeles Rosillo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective Effect of Hydroalcoholic Olive Leaf Extract on Experimental Model of Colitis in Rat: Involvement of Nitrergic and Opioidergic Systems

(2014) Nahid Fakhraei et al.   PHYTOTHERAPY RESEARCH

Olive Leaf Extracts Protect Cardiomyocytes against 4-Hydroxynonenal-Induced Toxicity In Vitro: Comparison with Oleuropein, Hydroxytyrosol, and Quercetin

(2014) Elif Bali et al.   PLANTA MEDICA

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Oleuropein Protects against Dextran Sodium Sulfate-Induced Chronic Colitis in Mice

(2013) Elisa Giner et al.   JOURNAL OF NATURAL PRODUCTS

Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice

(2013) Susana Sánchez-Fidalgo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice

(2012) Daniela Impellizzeri et al.   BIOCHEMICAL PHARMACOLOGY

The Complexities of Epidemiology and Prevention of Gastrointestinal Cancers

(2012) Saba Haq et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Olive Oil and Haemostasis: Platelet Function, Thrombogenesis and Fibrinolysis

(2011) Javier Delgado-Lista et al.   CURRENT PHARMACEUTICAL DESIGN

Oleuropein Ameliorates Acute Colitis in Mice

(2011) Elisa Giner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells

(2011) Riadh Drira et al.   LIFE SCIENCES

Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress

(2011) Ildefonso Rodríguez-Ramiro et al.   TOXICOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE