Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

The French National Nutrition and Health Program Score Is Associated with Nutritional Status and Risk of Major Chronic Diseases

(2018) Carla Estaquio et al.   JOURNAL OF NUTRITION

Naringin Inhibits ROS-activated MAPK Pathway in High Glucose-induced Injuries in H9c2 Cardiac Cells

(2013) Jingfu Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice

(2013) Yan Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract

(2013) Gilbert R. Kaats et al.   FOOD AND CHEMICAL TOXICOLOGY

Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus

(2013) T. Annadurai et al.   FREE RADICAL RESEARCH

Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway

(2013) HAILI HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjects

(2013) Nancy P Aptekmann et al.   Lipids in Health and Disease

Naringin Improves Diet-Induced Cardiovascular Dysfunction and Obesity in High Carbohydrate, High Fat Diet-Fed Rats

(2013) Md. Alam et al.   Nutrients

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by β-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

(2012) Seong-Il Kang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway

(2012) Chia-Yu Lin et al.   CYTOKINE

Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1

(2012) Siyu Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

(2012) Zong-Tsi Chen et al.   FOOD CHEMISTRY

Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats

(2012) Mehrdad Roghani et al.   INDIAN JOURNAL OF PHARMACOLOGY

Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice

(2012) Hae-Jin Park et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin–nicotinamide-induced experimental diabetic rats

(2012) T. Annadurai et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults

(2012) Caitlin A. Dow et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway

(2012) K. Gopinath et al.   NEUROSCIENCE

Preventive Effects of Hesperidin, Glucosyl Hesperidin and Naringin on Hypertension and Cerebral Thrombosis in Stroke-prone Spontaneously Hypertensive Rats

(2012) Miyako Ikemura et al.   PHYTOTHERAPY RESEARCH

Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice

(2012) Zhi-Hong Yang et al.   Diabetology & Metabolic Syndrome

Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet

(2011) Peng Pu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

Anti-inflammatory and Antifibrotic Effects of Naringenin in Diabetic Mice

(2011) Shih-Jei Tsai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Adherence to French Nutritional Guidelines Is Associated with Lower Risk of Metabolic Syndrome

(2011) Emmanuelle Kesse‐Guyot et al.   JOURNAL OF NUTRITION

Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice

(2011) Audrey Chanet et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway

(2011) Elena Bravo et al.   Lipids in Health and Disease

Naringenin Decreases Progression of Atherosclerosis by Improving Dyslipidemia in High-Fat–Fed Low-Density Lipoprotein Receptor–Null Mice

(2010) Erin E. Mulvihill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fruit juice inhibition of uptake transport: a new type of food-drug interaction

(2010) David G. Bailey   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Shifts in Diet from High Fat to High Carbohydrate Improved Levels of Adipokines and Pro-inflammatory Cytokines in Mice Fed a High-fat Diet

(2010) In Seok LEE et al.   ENDOCRINE JOURNAL

Dietary naringenin increases hepatic peroxisome proliferators–activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats

(2010) Kae Won Cho et al.   EUROPEAN JOURNAL OF NUTRITION

Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats

(2010) Sriramajayam Kannappan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats

(2010) Leelavinothan Pari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies

(2010) Vincenzo Mollace et al.   FITOTERAPIA

Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation

(2010) Mandipika Jain et al.   INFLAMMATION RESEARCH

Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes

(2010) Deena Ramful et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In VitroProtective Effects of Two Extracts from Bergamot Peels on Human Endothelial Cells Exposed to Tumor Necrosis Factor-α (TNF-α)

(2010) Domenico Trombetta et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High-carbohydrate, High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

(2010) Sunil K. Panchal et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Developmental Origins, Mechanisms, and Implications of Metabolic Syndrome

(2010) Kimberley D. Bruce et al.   JOURNAL OF NUTRITION

Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study

(2010) Monica Cavia-Saiz et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies

(2010) Shizuka Hirai et al.   MEDIATORS OF INFLAMMATION

Naringenin chalcone improves adipocyte functions by enhancing adiponectin production

(2010) Taro Horiba et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor-Null Mice With Diet-Induced Insulin Resistance

(2009) E. E. Mulvihill et al.   DIABETES

Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin

(2009) J. Renugadevi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange

(2009) Rafaela Guimarães et al.   FOOD AND CHEMICAL TOXICOLOGY

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Naringin inhibits matrix metalloproteinase-9 expression and AKT phosphorylation in tumor necrosis factor-α-induced vascular smooth muscle cells

(2009) Eo-Jin Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats

(2008) V. R. Punithavathi et al.   JOURNAL OF APPLIED TOXICOLOGY

Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue

(2008) Yoshiko Fukuchi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor

(2008) Emma M. Allister et al.   JOURNAL OF LIPID RESEARCH

Understanding the Cardioprotective Effects of Flavonols: Discovery of Relaxant Flavonols without Antioxidant Activity

(2008) Cheng Xue Qin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

(2008) Ximena Terra et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE)

(2008) Constantin Dallas et al.   PHYTOMEDICINE

Effect of Flavonoids on Daunorubicin-induced Toxicity in H9c2 Cardiomyoblasts

(2008) Gabriela Mojžišová et al.   PHYTOTHERAPY RESEARCH

Cardioprotective Effect of Naringin in Mice Treated with Doxorubicin

(2008) TK Reddy et al.   PLANTA MEDICA

Naringenin protects against cadmium-induced oxidative renal dysfunction in rats

(2008) J. Renugadevi et al.   TOXICOLOGY

(+/−)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells

(2006) S Saponara et al.   BRITISH JOURNAL OF PHARMACOLOGY