Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy

Direct interaction between CEP85 and STIL mediates PLk4-driven directed cell migration

(2020) Yi Liu et al.   JOURNAL OF CELL SCIENCE

Inhibition of PLK4 might enhance the anti‐tumour effect of bortezomib on glioblastoma via PTEN/PI3K/AKT/mTOR signalling pathway

(2020) Jing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

(2020) Qingyang Lei et al.   Frontiers in Cell and Developmental Biology

Polo‑like kinase�4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma

(2019) Jia Wang et al.   ONCOLOGY REPORTS

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

(2019) Amreena Suri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lung Cancer

(2019) Faria Nasim et al.   MEDICAL CLINICS OF NORTH AMERICA

Role for polo-like kinase 4 in mediation of cytokinesis

(2019) Michael F. Press et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

(2019) Kazuya Shinmura et al.   Cancers

Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability

(2019) Dong Hyun Kim et al.   Cell Death & Disease

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

(2019) Shohei Yamamoto et al.   Nature Communications

A cis ‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma

(2019) Lijuan Meng et al.   Cancer Medicine

PLK 4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome

(2019) Xiao‐Dong Yang et al.   EMBO JOURNAL

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

(2019) Jung-Eun Park et al.   Nature Communications

Polo‐like kinase 4 correlates with greater tumor size, lymph node metastasis and confers poor survival in non‐small cell lung cancer

(2019) Qin Zhou et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

(2019) Devesh Tewari et al.   SEMINARS IN CANCER BIOLOGY

Cervical Cancer Worldwide

(2018) Mailinh Vu et al.   CURRENT PROBLEMS IN CANCER

Emerging therapeutic targets for the treatment of malignant rhabdoid tumors

(2018) Karolina Nemes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fast and furious . . . or not, Plk4 dictates the pace

(2018) Simon Gemble et al.   JOURNAL OF CELL BIOLOGY

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

(2018) Ryan A. Denu et al.   MOLECULAR CANCER RESEARCH

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Arp2/3 Regulatory System and Its Deregulation in Cancer

(2018) Nicolas Molinie et al.   PHYSIOLOGICAL REVIEWS

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

(2018) Masanori Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

(2018) Xiangdong Tian et al.   Cell Death & Disease

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

(2018) Yi Liu et al.   Nature Communications

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

(2018) Wenjun Lan et al.   Scientific Reports

Exploring the links between cancer and placenta development

(2018) Vincenzo Costanzo et al.   Open Biology

OUP accepted manuscript

(2018)   ANNALS OF ONCOLOGY

Targeting the cell cycle in breast cancer: towards the next phase

(2018) KL Thu et al.   CELL CYCLE

Targeted Therapy and Immune Therapy for Small Cell Lung Cancer

(2018) Shirish M. Gadgeel   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Regulating a key mitotic regulator, polo‐like kinase 1 (PLK1)

(2018) Erica G. Colicino et al.   Cytoskeleton

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect

(2018) Qian Lei et al.   Cell Death & Disease

MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway

(2018) Jie Bao et al.   Cell Death & Disease

PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

(2018) Zuoxin Zhang et al.   CANCER LETTERS

Analysis of centrosome and DNA damage response in PLK4 associated Seckel syndrome

(2017) Tuba Dinçer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ATAD2 in cancer: a pharmacologically challenging but tractable target

(2017) Muzammal Hussain et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage

(2017) Qian Zhang et al.   FERTILITY AND STERILITY

Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering

(2017) Cristina Parola et al.   IMMUNOLOGY

Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis

(2017) Yuji Nakayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

(2017) Lindsey N. Kent et al.   JOURNAL OF CLINICAL INVESTIGATION

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial

(2017) Padmanee Sharma et al.   LANCET ONCOLOGY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

(2017) James R. Perry et al.   NEW ENGLAND JOURNAL OF MEDICINE

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

(2017) Simone Treiger Sredni et al.   PEDIATRIC BLOOD & CANCER

Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy

(2017) Lais Osmani et al.   SEMINARS IN CANCER BIOLOGY

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

(2017) Edward J. Morris et al.   Nature Communications

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

(2017) Simone Treiger Sredni et al.   Oncotarget

Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles

(2016) Yijuan Zhang et al.   ACS Nano

A randomized, double-blind, placebo-controlled phase II study to assess the efficacy and safety of mapatumumab with sorafenib in patients with advanced hepatocellular carcinoma

(2016) T. Ciuleanu et al.   ANNALS OF ONCOLOGY

A phase Ib study of selumetinib (AZD6244, ARRY-142886) in combination with sorafenib in advanced hepatocellular carcinoma (HCC)

(2016) W. M. Tai et al.   ANNALS OF ONCOLOGY

Targeting cancer using KAT inhibitors to mimic lethal knockouts

(2016) J. A. L. Brown et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication

(2016) Kathrin Brunk et al.   JOURNAL OF CELL SCIENCE

Medulloblastoma

(2016) Nathan E. Millard et al.   JOURNAL OF CHILD NEUROLOGY

Molecular interactions of polo-like kinase 1 in human cancers

(2016) Wayne Tiong Weng Ng et al.   JOURNAL OF CLINICAL PATHOLOGY

Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy

(2016) Min Yan et al.   MEDICINAL RESEARCH REVIEWS

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies

(2016) Michael C. Frühwald et al.   NEURO-ONCOLOGY

Functions of Polo-Like Kinases: A Journey From Yeast To Humans

(2016) Rajni Vaid et al.   PROTEIN AND PEPTIDE LETTERS

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

(2016) Ines Lohse et al.   Oncotarget

Expression of Polo-Like Kinase 4(PLK4) in Breast Cancer and Its Response to Taxane-Based Neoadjuvant Chemotherapy

(2016) Zhenhua Li et al.   Journal of Cancer

Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer

(2015) Ying Li et al.   ACS Nano

Pancreatic Cancer: Pathogenesis and Diagnosis

(2015) Vedat Goral   Asian Pacific Journal of Cancer Prevention

A Threshold Level of Intratumor CD8 + T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1

(2015) Shin Foong Ngiow et al.   CANCER RESEARCH

PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space

(2015) Carla A.M. Lopes et al.   DEVELOPMENTAL CELL

MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome

(2015) Kunning Wang et al.   GUT

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis

(2015) L.  ajanek et al.   JOURNAL OF CELL SCIENCE

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

(2015) Wies van Roosmalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Understanding the Polo Kinase machine

(2015) V Archambault et al.   ONCOGENE

The role of Plk3 in oncogenesis

(2015) C Helmke et al.   ONCOGENE

Autoinhibition and relief mechanism for Polo-like kinase 4

(2015) Joseph E. Klebba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos

(2015) R. C. McCoy et al.   SCIENCE

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

PLK1 regulates spindle formation kinetics and APC/C activation in mouse zygote

(2015) Vladimir Baran et al.   ZYGOTE

The Centrosome and Its Duplication Cycle

(2015) Jingyan Fu et al.   Cold Spring Harbor Perspectives in Biology

Loss of KLF14 triggers centrosome amplification and tumorigenesis

(2015) Guangjian Fan et al.   Nature Communications

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

(2015) D. S. Thommen et al.   Cancer Immunology Research

Melanoma

(2015) Dirk Schadendorf et al.   Nature Reviews Disease Primers

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

(2015) Nina Korzeniewski et al.   NEOPLASIA

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Changing incidence and improved survival of gliomas

(2014) Vincent K.Y. Ho et al.   EUROPEAN JOURNAL OF CANCER

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

A novel gene–protein assay for evaluating HER2 status in gastric cancer: simultaneous analyses of HER2 protein overexpression and gene amplification reveal intratumoral heterogeneity

(2014) Yasunori Nishida et al.   Gastric Cancer

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

(2014) M.-Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel role for Plk4 in regulating cell spreading and motility

(2014) C O Rosario et al.   ONCOGENE

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

(2014) Alejandra Ward et al.   PLoS One

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors

(2013) Miki Kiyota et al.   APOPTOSIS

NFκB regulates expression of Polo-like kinase 4

(2013) Adeline Ledoux et al.   CELL CYCLE

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

(2013) H. A. Yu et al.   CLINICAL CANCER RESEARCH

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance

(2012) Kamlesh Sodani et al.   BIOCHEMICAL PHARMACOLOGY

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

(2012) M. S. Raab et al.   CANCER RESEARCH

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)

(2012) Onur Cizmecioglu et al.   JOURNAL OF CELL SCIENCE

NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

(2012) B. Valsasina et al.   MOLECULAR CANCER THERAPEUTICS

Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis

(2012) Lili Liu et al.   PLoS One

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

(2012) Lauren K. Slevin et al.   STRUCTURE

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

(2011) Alejandra Ward et al.   BMC CANCER

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

(2011) S. Abe et al.   GENES & DEVELOPMENT

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

(2011) Christopher W. Brownlee et al.   JOURNAL OF CELL BIOLOGY

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

(2011) G. de Carcer et al.   MOLECULAR AND CELLULAR BIOLOGY

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

(2011) Nina Korzeniewski et al.   Molecular Cancer

FBXW5 controls centrosome number

(2011) Julia Pagan et al.   NATURE CELL BIOLOGY

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

(2011) Anja Puklowski et al.   NATURE CELL BIOLOGY

CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes

(2011) Nathalie Franck et al.   PLoS One

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

Genomic instability and cancer: Lessons learned from human papillomaviruses

(2010) Nina Korzeniewski et al.   CANCER LETTERS

Centriole duplication

(2010) Andrew J. Holland et al.   CELL CYCLE

Centriole Reduplication during Prolonged Interphase Requires Procentriole Maturation Governed by Plk1

(2010) Jadranka Lončarek et al.   CURRENT BIOLOGY

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle

(2010) Jaerak Chang et al.   EMBO JOURNAL

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Cep152 interacts with Plk4 and is required for centriole duplication

(2010) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

Stepwise evolution of the centriole-assembly pathway

(2010) Z. Carvalho-Santos et al.   JOURNAL OF CELL SCIENCE

The relationship between early embryo development and tumourigenesis

(2010) Yanlei Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

Plk4 is required for cytokinesis and maintenance of chromosomal stability

(2010) C. O. Rosario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4: the odd one out of the family

(2010) James E Sillibourne et al.   Cell Division

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Centrosome abnormalities during aChlamydia trachomatisinfection are caused by dysregulation of the normal duplication pathway

(2009) Kirsten A. Johnson et al.   CELLULAR MICROBIOLOGY

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

(2009) Maria Angelica Cortez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma

(2009) Rossella Pellegrino et al.   HEPATOLOGY

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication

(2009) James E. Sillibourne et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA