PLK 4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome
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Title
PLK
4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome
Authors
Keywords
-
Journal
EMBO JOURNAL
Volume -, Issue -, Pages -
Publisher
EMBO
Online
2019-11-25
DOI
10.15252/embj.2019102201
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Note: Only part of the references are listed.- ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination
- (2019) Guangming Ren et al. EMBO JOURNAL
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- PLK4: a link between centriole biogenesis and cancer
- (2017) Radhika Radha Maniswami et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination
- (2017) Ran Wei et al. GENES & DEVELOPMENT
- Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
- (2017) Rong Tan et al. MOLECULAR CELL
- MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
- (2017) Xuan Li et al. Nature Communications
- The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release
- (2016) Anastassiia Vertii et al. DEVELOPMENTAL CELL
- SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes
- (2016) Sebastian A Wagner et al. EMBO JOURNAL
- SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death
- (2016) Lisa Schlicher et al. EMBO REPORTS
- Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?
- (2016) Gloria Lopez-Castejon et al. MEDIATORS OF INFLAMMATION
- SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
- (2016) Paul R. Elliott et al. MOLECULAR CELL
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- The Centrosome, a Multitalented Renaissance Organelle
- (2016) Anastassiia Vertii et al. Cold Spring Harbor Perspectives in Biology
- SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
- (2016) Sebastian Kupka et al. Cell Reports
- CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
- (2016) Matous Hrdinka et al. Cell Reports
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
- (2015) Gagan D. Gupta et al. CELL
- A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity
- (2015) Bao H. Duong et al. IMMUNITY
- A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
- (2015) Jonathan L. Schmid-Burgk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Reversible centriole depletion with an inhibitor of Polo-like kinase 4
- (2015) Y. L. Wong et al. SCIENCE
- Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock
- (2014) Tom Vanden Berghe et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6
- (2014) Yunfan Yang et al. CELL RESEARCH
- Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
- (2014) Lieselotte Vande Walle et al. NATURE
- Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
- (2013) Takuma Misawa et al. NATURE IMMUNOLOGY
- Regulation of NF-κB by deubiquitinases
- (2012) Edward W. Harhaj et al. IMMUNOLOGICAL REVIEWS
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
- (2011) Beckley K. Davis et al. Annual Review of Immunology
- Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
- (2011) Nicolas Chevrier et al. CELL
- Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
- (2011) Greta Guarda et al. IMMUNITY
- NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells
- (2011) S. Kim et al. JOURNAL OF CELL SCIENCE
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing
- (2010) Petr Broz et al. Cell Host & Microbe
- CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes
- (2009) S-C Sun CELL DEATH AND DIFFERENTIATION
- CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
- (2009) Sara A Wickström et al. EMBO JOURNAL
- Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities
- (2009) Roland Hjerpe et al. EMBO REPORTS
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