Loss of KLF14 triggers centrosome amplification and tumorigenesis

Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy?

(2014) Andrew J. Holland et al.   CANCER CELL

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

(2014) J. Chen et al.   CANCER RESEARCH

New Role for Kruppel-like Factor 14 as a Transcriptional Activator Involved in the Generation of Signaling Lipids

(2014) Thiago M. de Assuncao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

(2014) M.-Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases

(2013) Zhongwei Qiu et al.   NUCLEIC ACIDS RESEARCH

Mitotic catastrophe and cell death induced by depletion of centrosomal proteins

(2013) M Kimura et al.   Cell Death & Disease

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

(2013) Takanori Nakamura et al.   Nature Communications

Centrosome amplification in tumorigenesis

(2012) Simon J. Anderhub et al.   CANCER LETTERS

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

(2012) Chen Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis

(2012) Lili Liu et al.   PLoS One

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors ofKRAS-mediated cell growth

(2011) Martin E. Fernandez-Zapico et al.   BIOCHEMICAL JOURNAL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

(2011) Christopher W. Brownlee et al.   JOURNAL OF CELL BIOLOGY

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

(2011) Kerrin S Small et al.   NATURE GENETICS

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centriole duplication

(2010) Andrew J. Holland et al.   CELL CYCLE

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

Plk4 is required for cytokinesis and maintenance of chromosomal stability

(2010) C. O. Rosario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4: the odd one out of the family

(2010) James E Sillibourne et al.   Cell Division

Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts

(2009) Alan Morettin et al.   BMC GENOMICS

Cullin 1 Functions as a Centrosomal Suppressor of Centriole Multiplication by Regulating Polo-like Kinase 4 Protein Levels

(2009) N. Korzeniewski et al.   CANCER RESEARCH

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

Centrosome function in cancer: guilty or innocent?

(2009) Deborah Zyss et al.   TRENDS IN CELL BIOLOGY

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

(2008) Elisabeth Castellanos et al.   CURRENT BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY