Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

(2017) Nikola S. Dzhindzhev et al.   Open Biology

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

(2017) Matthew A. Cottee et al.   Biology Open

The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction

(2015) C. Chen et al.   JOURNAL OF CELL SCIENCE

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Probing protein interactions in living mammalian cells on a microtubule bench

(2015) Mirela Boca et al.   Scientific Reports

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication

(2014) Elif Nur Firat-Karalar et al.   CURRENT BIOLOGY

STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification

(2014) Christian Arquint et al.   CURRENT BIOLOGY

SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication

(2014) Chii Shyang Fong et al.   DEVELOPMENTAL CELL

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Centrosomes as signalling centres

(2014) C. Arquint et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structure of the SAS-6 cartwheel hub from Leishmania major

(2014) Mark van Breugel et al.   eLife

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1

(2013) Stephen E. Kaiser et al.   Autophagy

CEP120 and SPICE1 Cooperate with CPAP in Centriole Elongation

(2013) David Comartin et al.   CURRENT BIOLOGY

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron

(2013) Joseph E. Klebba et al.   CURRENT BIOLOGY

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

(2013) Matthew A Cottee et al.   eLife

Deconstructing the centriole: structure and number control

(2012) Daniela A Brito et al.   CURRENT OPINION IN CELL BIOLOGY

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Cell-cycle-regulated expression of STIL controls centriole number in human cells

(2012) C. Arquint et al.   JOURNAL OF CELL SCIENCE

STIL is required for centriole duplication in human cells

(2012) J. Vulprecht et al.   JOURNAL OF CELL SCIENCE

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

Building the Centriole

(2010) Juliette Azimzadeh et al.   CURRENT BIOLOGY

DSas-6 and Ana2 Coassemble into Tubules to Promote Centriole Duplication and Engagement

(2010) Naomi R. Stevens et al.   DEVELOPMENTAL CELL

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

DrosophilaAna2 is a conserved centriole duplication factor

(2010) Naomi R. Stevens et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

The Conserved Protein SZY-20 Opposes the Plk4-Related Kinase ZYG-1 to Limit Centrosome Size

(2008) Mi Hye Song et al.   DEVELOPMENTAL CELL

Mechanisms of procentriole formation

(2008) Petr Strnad et al.   TRENDS IN CELL BIOLOGY