Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

The centrosome duplication cycle in health and disease

(2014) Erich A. Nigg et al.   FEBS LETTERS

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model

(2014) Z. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The centriole duplication cycle

(2014) E. N. F rat-Karalar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The centrosome-Golgi apparatus nexus

(2014) R. M. Rios   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

(2014) Denisse Izquierdo et al.   Cell Reports

Cohesion fatigue

(2013) Gary J. Gorbsky   CURRENT BIOLOGY

Deuterosome-Mediated Centriole Biogenesis

(2013) Deborah A. Klos Dehring et al.   DEVELOPMENTAL CELL

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

p53 N-terminal phosphorylation: a defining layer of complex regulation

(2012) L. M. M. Jenkins et al.   CARCINOGENESIS

Deconstructing the centriole: structure and number control

(2012) Daniela A Brito et al.   CURRENT OPINION IN CELL BIOLOGY

Cilia functions in development

(2012) Iain A Drummond   CURRENT OPINION IN CELL BIOLOGY

Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

(2012) J. L. Stubbs et al.   NATURE CELL BIOLOGY

Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material

(2012) Steffen Lawo et al.   NATURE CELL BIOLOGY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists

(2011) Hong Shen et al.   CURRENT PHARMACEUTICAL DESIGN

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

(2010) Dominic A. Sloane et al.   ACS Chemical Biology

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation

(2010) M. Stiess et al.   SCIENCE

Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli

(2009) Miranda L. Cox et al.   CELLULAR SIGNALLING

Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors

(2009) Irini Akritopoulou-Zanze et al.   DRUG DISCOVERY TODAY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

The mammalian centrosome and its functional significance

(2008) Heide Schatten   HISTOCHEMISTRY AND CELL BIOLOGY