ATAD2 in cancer: a pharmacologically challenging but tractable target
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ATAD2 in cancer: a pharmacologically challenging but tractable target
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 22, Issue 1, Pages 85-96
Publisher
Informa UK Limited
Online
2017-11-17
DOI
10.1080/14728222.2018.1406921
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases
- (2016) Zhong-Yin Zhang ACCOUNTS OF CHEMICAL RESEARCH
- A Chemical Probe for the ATAD2 Bromodomain
- (2016) Paul Bamborough et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Drugging Undruggable Molecular Cancer Targets
- (2016) John S. Lazo et al. Annual Review of Pharmacology and Toxicology
- Rare ATAD5 missense variants in breast and ovarian cancer patients
- (2016) Ivana Maleva Kostovska et al. CANCER LETTERS
- Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma
- (2016) Alip Ghosh et al. International Journal of Biological Sciences
- Exploring the role of water in molecular recognition: predicting protein ligandability using a combinatorial search of surface hydration sites
- (2016) Sinisa Vukovic et al. JOURNAL OF PHYSICS-CONDENSED MATTER
- ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication
- (2016) Seong Joo Koo et al. Oncotarget
- Drugging the “undruggable” DNA-binding domain of STAT3
- (2016) Jian-Ting Zhang et al. Oncotarget
- Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains
- (2016) Akifumi Nakagawa et al. Scientific Reports
- Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2
- (2015) Guillaume Poncet-Montange et al. BIOCHEMICAL JOURNAL
- Cell cycle regulation of human DNA repair and chromatin remodeling genes
- (2015) Robin Mjelle et al. DNA REPAIR
- Mitochondria-Associated Membrane Formation in Hormone-Stimulated Leydig Cell Steroidogenesis: Role of ATAD3
- (2015) Leeyah Issop et al. ENDOCRINOLOGY
- Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors
- (2015) Paul Bamborough et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
- (2015) Emmanuel H. Demont et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics
- (2015) Min Xu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer
- (2015) LE ZHENG et al. ONCOLOGY REPORTS
- Overexpression of ANCCA/ATAD2 in endometrial carcinoma and its correlation with tumor progression and poor prognosis
- (2015) Pan Shang et al. TUMOR BIOLOGY
- ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells
- (2015) Yang Luo et al. Gastroenterology Research and Practice
- Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells
- (2015) Yuichi Morozumi et al. Journal of Molecular Cell Biology
- ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma
- (2015) Camilla Krakstad et al. Oncotarget
- Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling
- (2015) Wen-Jing Lu et al. Oncotarget
- Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy
- (2015) Ruiyang Yan et al. BIOCHEMICAL JOURNAL
- ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis
- (2014) Wei-Na Wan et al. Asian Pacific Journal of Cancer Prevention
- miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis
- (2014) Gang Wu et al. BMC CANCER
- Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma
- (2014) GANG WU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Fragment-Based Screening of the Bromodomain of ATAD2
- (2014) Mary J. Harner et al. JOURNAL OF MEDICINAL CHEMISTRY
- Retraction for Li et al., “ATAD3 Is a Limiting Factor in Mitochondrial Biogenesis and Adipogenesis of White Adipocyte-Like 3T3-L1 Cells”
- (2014) Shuijie Li et al. MOLECULAR AND CELLULAR BIOLOGY
- Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance
- (2014) June X. Zou et al. MOLECULAR CANCER RESEARCH
- Lessons from Yeast on Emerging Roles of the ATAD2 Protein Family in Gene Regulation and Genome Organization
- (2014) Matteo Cattaneo et al. MOLECULES AND CELLS
- RNAi Therapies: Drugging the Undruggable
- (2014) S. Y. Wu et al. Science Translational Medicine
- Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
- (2014) Apirat Chaikuad et al. MedChemComm
- A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening
- (2014) Jouhyun Jeon et al. Genome Medicine
- Malignant genome reprogramming by ATAD2
- (2013) Fayçal Boussouar et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- The impact of personalized medicine on survival: Comparisons of results in metastatic breast, colorectal and non-small-cell lung cancers
- (2013) Antonio Rossi et al. CANCER TREATMENT REVIEWS
- Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex?
- (2013) Takashi Kubota et al. CELL CYCLE
- ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
- (2013) Kyoo-young Lee et al. JOURNAL OF CELL BIOLOGY
- Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse
- (2013) Tobias Goller et al. PLoS One
- Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers
- (2013) Maria B. Raeder et al. PLoS One
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay
- (2012) Judith Elkaim et al. BIOCHEMICAL JOURNAL
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- RNAi-mediated gene silencing in cancer therapy
- (2012) Wei-Qiong Yang et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
- (2012) J. Liu et al. GENOME RESEARCH
- ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression
- (2012) Shuijie Li et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites
- (2012) Lewis R. Vidler et al. JOURNAL OF MEDICINAL CHEMISTRY
- Target Validation to Biomarker Development
- (2012) Riccardo Colombo et al. Molecular Diagnosis & Therapy
- Direct Cooperation Between Androgen Receptor and E2F1 Reveals a Common Regulation Mechanism for Androgen-Responsive Genes in Prostate Cells
- (2012) D. M. Altintas et al. MOLECULAR ENDOCRINOLOGY
- Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
- (2012) Ari J. Firestone et al. NATURE
- Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
- (2012) Zhijian Duan et al. PROSTATE
- What makes a good drug target?
- (2011) Isabella Gashaw et al. DRUG DISCOVERY TODAY
- What makes a good drug target?
- (2011) Isabella Gashaw et al. DRUG DISCOVERY TODAY
- Bromodomains as therapeutic targets
- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- ATAD3, une ATPase membranaire mitochondriale vitale impliquée dans la progression tumorale
- (2011) Shuijie Li et al. M S-MEDECINE SCIENCES
- Predictive biomarkers: a paradigm shift towards personalized cancer medicine
- (2011) Nicholas B. La Thangue et al. Nature Reviews Clinical Oncology
- Identification of Tumor Suppressors and Oncogenes from Genomic and Epigenetic Features in Ovarian Cancer
- (2011) Kazimierz O. Wrzeszczynski et al. PLoS One
- RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma
- (2011) Qichao Huang et al. PLoS One
- Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
- (2011) T.-F. Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5
- (2011) Daphne W. Bell et al. PLoS Genetics
- ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2
- (2010) E. V. Kalashnikova et al. CANCER RESEARCH
- ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis
- (2010) Nathaniel T. Leachman et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark
- (2010) A. S. Revenko et al. MOLECULAR AND CELLULAR BIOLOGY
- Deregulated E2F and the AAA+ Coregulator ANCCA Drive Proto-Oncogene ACTR/AIB1 Overexpression in Breast Cancer
- (2010) E. Y.C. Hsia et al. MOLECULAR CANCER RESEARCH
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers
- (2010) C Caron et al. ONCOGENE
- Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer
- (2009) J. X. Zou et al. CANCER RESEARCH
- ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors
- (2009) M. Ciro et al. CANCER RESEARCH
- In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: it is the time to combine
- (2009) Olivier Vidalin et al. CURRENT OPINION IN PHARMACOLOGY
- Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
- (2009) H. B. Salvesen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AAA+ proteins: diversity in function, similarity in structure
- (2008) Jamie Snider et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The AAA+ superfamily of functionally diverse proteins
- (2008) Jamie Snider et al. GENOME BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now