Molecular interactions of polo-like kinase 1 in human cancers

Polo-like kinase and its inhibitors: Ready for the match to start?

(2015) Neil D. Palmisiano et al.   AMERICAN JOURNAL OF HEMATOLOGY

Combined Immunohistochemistry of PLK1, p21, and p53 for Predicting TP53 Status

(2015) Gou Watanabe et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Polo-like kinase 1 inhibits DNA damage response during mitosis

(2015) Jan Benada et al.   CELL CYCLE

The deregulated promoter methylation of thePolo-like kinasesas a potential biomarker in hematological malignancies

(2015) Alejandra Ward et al.   LEUKEMIA & LYMPHOMA

Upregulated Polo-Like Kinase 1 Expression Correlates with Inferior Survival Outcomes in Rectal Cancer

(2015) T. G. Tut et al.   PLoS One

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

(2014) H. Dohner et al.   BLOOD

Polo-like kinase-1 in DNA damage response

(2014) Sun-Yi Hyun et al.   BMB Reports

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

(2014) Alejandra Ward et al.   PLoS One

Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage

(2014) Y-C Lin et al.   Cell Death & Disease

Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

(2013) Hyungshin Yim   ANTI-CANCER DRUGS

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence?

(2013) B. D. Cholewa et al.   CANCER RESEARCH

p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53–E2F1–DNA complex

(2013) Zhe Zhou et al.   EXPERIMENTAL CELL RESEARCH

Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G2/M Checkpoint through the Aurora A Cofactor Bora Protein

(2013) Bo Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel DNA damage checkpoint in mitosis: Mitotic DNA damage induces re-replication without cell division in various cancer cells

(2012) Sun-Yi Hyun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas – a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network

(2012) K Mross et al.   BRITISH JOURNAL OF CANCER

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

(2012) Keiko Yata et al.   MOLECULAR CELL

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

(2011) Alejandra Ward et al.   BMC CANCER

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress

(2011) B. Song et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-Like Kinase 1 as Predictive Marker and Therapeutic Target for Radiotherapy in Rectal Cancer

(2010) Franz Rödel et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

Mitotic DNA damage response: Polo-like Kinase-1 is dephosphorylated through ATM-Chk1 pathway

(2010) Hee-Jae Lee et al.   CELL CYCLE

Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

(2010) X Shawn Liu et al.   EMBO REPORTS

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Effect of antisense RNA targeting Polo-like kinase 1 on cell growth in A549 lung cancer cells

(2010) Qiong Zhou et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability

(2010) Y. Degenhardt et al.   MOLECULAR CANCER THERAPEUTICS

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1-Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis

(2009) A. G. Gilmartin et al.   CANCER RESEARCH

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics

(2009) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Plk1-mediated Phosphorylation of Topors Regulates p53 Stability

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear cyclin D1: An oncogenic driver in human cancer

(2009) Jong Kyong Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

The balance of Polo-like kinase 1 in tumorigenesis

(2009) Lin-Yu Lu et al.   Cell Division

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

(2008) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

The spindle pole body plays a key role in controlling mitotic commitment in the fission yeastSchizosaccharomyces pombe

(2008) Iain M. Hagan   BIOCHEMICAL SOCIETY TRANSACTIONS

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

(2008) Mark Petronczki et al.   DEVELOPMENTAL CELL

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition

(2008) Nobumoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

(2008) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors

(2008) Klaus Mross et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcriptional regulation of human polo-like kinases and early mitotic inhibitor

(2008) Moe Tategu et al.   Journal of Genetics and Genomics

Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression

(2008) L.-Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone-Like NF-Y Is a Bifunctional Transcription Factor

(2008) M. Ceribelli et al.   MOLECULAR AND CELLULAR BIOLOGY

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

(2008) Zheng Fu et al.   NATURE CELL BIOLOGY

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE