Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

The melanocyte lineage in development and disease

(2015) R. L. Mort et al.   DEVELOPMENT

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

(2015) Lorena Landuzzi et al.   Oncotarget

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

(2014) Scott E. Williams et al.   NATURE CELL BIOLOGY

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Historical roots of centrosome research: discovery of Boveri's microscope slides in Wurzburg

(2014) U. Scheer   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles

(2013) Paula A. Coelho et al.   DEVELOPMENTAL CELL

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling

(2012) Moe R. Mahjoub et al.   CURRENT BIOLOGY

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

Role of epidermal primary cilia in the homeostasis of skin and hair follicles

(2011) M. J. Croyle et al.   DEVELOPMENT

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autosomal recessive primary microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum

(2011) Saqib Mahmood et al.   Orphanet Journal of Rare Diseases

The PI3K–Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability

(2010) Hyun-Ja Nam et al.   CARCINOGENESIS

Tilting at Nodal Windmills: Planar Cell Polarity Positions Cilia to Tell Left from Right

(2010) Nicole Santos et al.   DEVELOPMENTAL CELL

MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling

(2010) Marina Bershteyn et al.   DEVELOPMENTAL CELL

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)

(2008) Rudolf Reiter et al.   ACTA OTO-LARYNGOLOGICA

Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis

(2008) P. Finetti et al.   CANCER RESEARCH

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

(2008) Elisabeth Castellanos et al.   CURRENT BIOLOGY

The Mammalian SPD-2 Ortholog Cep192 Regulates Centrosome Biogenesis

(2008) Fei Zhu et al.   CURRENT BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Melanosomes at a glance

(2008) C. Wasmeier et al.   JOURNAL OF CELL SCIENCE

p53 family in development

(2008) Nadia Danilova et al.   MECHANISMS OF DEVELOPMENT

Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

(2007) Soline Estrach et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY