The role of Plk3 in oncogenesis

Crystal structure of the polo-box domain of polo-like kinase 2

(2015) Hong-Mei Shan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

(2014) H. Dohner et al.   BLOOD

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells

(2014) Monika Raab et al.   CELL RESEARCH

Current assessment of polo-like kinases as anti-tumor drug targets

(2014) Sandra N Craig et al.   Expert Opinion on Drug Discovery

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

(2014) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

(2014) Ganipisetti Srinivasrao et al.   PLoS One

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

(2014) Jennifer L Mamrosh et al.   eLife

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence?

(2013) B. D. Cholewa et al.   CANCER RESEARCH

RETRACTED: Peptide-Based Inhibitors of Plk1 Polo-box Domain Containing Mono-anionic Phosphothreonine Esters and Their Pivaloyloxymethyl Prodrugs

(2013) Wen-Jian Qian et al.   CHEMISTRY & BIOLOGY

Tenuigenin Attenuatesα-Synuclein-Induced Cytotoxicity by Down-Regulating Polo-Like Kinase 3

(2013) Jin-Xia Zhou et al.   CNS Neuroscience & Therapeutics

Bora and Aurora-A continue to activate Plk1 in mitosis

(2013) Wytse Bruinsma et al.   JOURNAL OF CELL SCIENCE

Structural basis for the inhibition of Polo-like kinase 1

(2013) Jun Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

(2013) M. Bergeron et al.   NEUROSCIENCE

Investigation on PLK2 and PLK3 substrate recognition

(2012) M. Salvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors

(2012) Y. Bai et al.   CANCER RESEARCH

Polo-like kinases in AML

(2012) Tobias Berg et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype

(2012) C. McInnes et al.   MOLECULAR CANCER THERAPEUTICS

NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

(2012) B. Valsasina et al.   MOLECULAR CANCER THERAPEUTICS

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

(2011) Juping Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

(2011) L. De Franceschi et al.   BLOOD

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints

(2011) Jianfang Wang et al.   CELLULAR SIGNALLING

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors

(2011) David L. Myer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

(2011) Monika Raab et al.   Nature Communications

Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: Self-versus non-self-priming

(2010) Kyung S. Lee et al.   CELL CYCLE

Hyperosmotic Stress-induced ATF-2 Activation through Polo-like Kinase 3 in Human Corneal Epithelial Cells

(2010) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of PTEN Stability and Activity by Plk3

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNA turnover rate limits siRNA and microRNA efficacy

(2010) Erik Larsson et al.   Molecular Systems Biology

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Lys-N and Trypsin Cover Complementary Parts of the Phosphoproteome in a Refined SCX-Based Approach

(2009) Sharon Gauci et al.   ANALYTICAL CHEMISTRY

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1-Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis

(2009) A. G. Gilmartin et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

(2009) Wolfgang Reindl et al.   CHEMBIOCHEM

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation

(2009) Meixiang Sang et al.   GENES TO CELLS

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SysPTM: A Systematic Resource for Proteomic Research on Post-translational Modifications

(2009) Hong Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Stimulation of Polo-Like Kinase 3 mRNA Decay by Tristetraprolin

(2009) T. J. Horner et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plk3 phosphorylates topoisomerase IIα at Thr1342, a site that is not recognized by Plk1

(2008) Masato Iida et al.   BIOCHEMICAL JOURNAL

GSK-3β Targets Cdc25A for Ubiquitin-Mediated Proteolysis, and GSK-3β Inactivation Correlates with Cdc25A Overproduction in Human Cancers

(2008) Tiebang Kang et al.   CANCER CELL

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1  under Hypoxic Conditions

(2008) Y. Yang et al.   CANCER RESEARCH

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

(2008) Mark Petronczki et al.   DEVELOPMENTAL CELL

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

(2008) V. Archambault et al.   GENES & DEVELOPMENT

Activation of Polo-like Kinase 3 by Hypoxic Stresses

(2008) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

The in vivo gene expression signature of oxidative stress

(2008) Eun-Soo Han et al.   PHYSIOLOGICAL GENOMICS

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE