Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization

(2016) Gleb Konotop et al.   CANCER RESEARCH

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

(2016) Pavithra L. Chavali et al.   Nature Communications

A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas

(2016) Karuna Mittal et al.   Journal of Ovarian Research

Abstract LB-253: Inhibition of stemness by BBI608 is sufficient to suppress cancer relapse and metastasis

(2015) Youzhi Li et al.   CANCER RESEARCH

Dis-organizing Centrosomal Clusters: Specific Cancer Therapy for a Generic Spread?

(2015) D. Bhakta-Guha et al.   CURRENT MEDICINAL CHEMISTRY

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Chronic centrosome amplification without tumorigenesis

(2015) Benjamin Vitre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal development, growth control, and homeostasis in the face of centrosome amplification

(2015) Anita Kulukian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

(2015) Lynnette R. Ferguson et al.   SEMINARS IN CANCER BIOLOGY

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers

(2015) Vaishali Pannu et al.   Oncotarget

Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum

(2015) Edward James Morris et al.   Scientific Reports

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

(2015) Eiko Kawamura et al.   Oncotarget

Excess centrosomes disrupt endothelial cell migration via centrosome scattering

(2014) Erich J. Kushner et al.   JOURNAL OF CELL BIOLOGY

E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

(2014) M.-Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets

(2014) N. Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death

(2014) A Ogden et al.   Cell Death & Disease

Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells

(2014) V Pannu et al.   Cell Death & Disease

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1

(2013) Victoria C. Silva et al.   MOLECULAR BIOLOGY OF THE CELL

Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma

(2013) Yunbao Pan et al.   PLoS One

Centrosome amplification in bladder washing cytology specimens is a useful prognostic biomarker for non-muscle invasive bladder cancer

(2013) Yoshihiro Miyachika et al.   Cancer Genetics

The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

(2013) Nagarajan Kannan et al.   Stem Cell Reports

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

(2012) M. S. Raab et al.   CANCER RESEARCH

The centrosome as potential target for cancer therapy and prevention

(2012) Nina Korzeniewski et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Merlin/ERM proteins establish cortical asymmetry and centrosome position

(2012) A. M. Hebert et al.   GENES & DEVELOPMENT

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Biological activity of piceatannol: Leaving the shadow of resveratrol

(2011) Hanna Piotrowska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A Time-Series Method for Automated Measurement of Changes in Mitotic and Interphase Duration from Time-Lapse Movies

(2011) Frederic D. Sigoillot et al.   PLoS One

Check your cultures! A list of cross-contaminated or misidentified cell lines

(2010) Amanda Capes-Davis et al.   INTERNATIONAL JOURNAL OF CANCER

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture

(2009) Karen M Imbalzano et al.   Cancer Cell International

Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression

(2009) J. J. Ranger et al.   CANCER RESEARCH

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

(2008) J. Hillion et al.   CANCER RESEARCH

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Paradigm shifts in the cell biology of STAT signaling

(2008) Pravin B. Sehgal   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY