Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

(2021) Thomas Philips et al.   Cell Reports

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

(2021) Caroline Eykens et al.   Molecular Therapy-Methods & Clinical Development

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

(2021) Sara Saez-Atienzar et al.   Science Advances

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

(2021) Marta Boccazzi et al.   Cell Death & Disease

RNS60, a physically-modified saline, inhibits glial activation, suppresses neuronal apoptosis and protects memory in a mouse model of traumatic brain injury

(2020) Suresh B. Rangasamy et al.   EXPERIMENTAL NEUROLOGY

Regulation and signaling of the GPR17 receptor in oligodendroglial cells

(2020) Davide Lecca et al.   GLIA

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

(2020) Roberta Marisca et al.   NATURE NEUROSCIENCE

Myelin Plasticity and Repair: Neuro-Glial Choir Sets the Tuning

(2020) Remi Ronzano et al.   Frontiers in Cellular Neuroscience

Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis

(2020) Andrew P. Robinson et al.   Scientific Reports

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

(2020) Sandra Carrera-Juliá et al.   Frontiers in Physiology

Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

(2020) Davide Capelli et al.   Frontiers in Chemistry

Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment

(2020) Tereza Filipi et al.   Journal of Clinical Medicine

Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair

(2020) Davide Marangon et al.   Journal of Clinical Medicine

Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System

(2020) Erik Nutma et al.   Cells

Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models

(2020) Benjamin A. Harlan et al.   EXPERIMENTAL NEUROLOGY

Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation

(2020) Kelly M. Guzman et al.   GLIA

Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice

(2020) Elisabetta Bonfanti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis

(2020) Alejandro Lorente Pons et al.   JOURNAL OF PATHOLOGY

Tamoxifen for amyotrophic lateral sclerosis

(2020) Po-Chih Chen et al.   MEDICINE

Activation of the Notch Signaling Pathway and Cellular Localization of Notch Signaling Molecules in the Spinal Cord of SOD1-G93A ALS Model Mice

(2020) Chong Liu et al.   NEUROSCIENCE

Diminished ventral oligodendrocyte precursor generation results in the subsequent over-production of dorsal oligodendrocyte precursors of aberrant morphology and function

(2020) Lev Starikov et al.   NEUROSCIENCE

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development

(2020) Valentina Pegoretti et al.   Oxidative Medicine and Cellular Longevity

Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

(2020) Chiara Parravicini et al.   PLoS One

Effects of Biotin on survival, ensheathment, and ATP production by oligodendrocyte lineage cells in vitro

(2020) Qiao-Ling Cui et al.   PLoS One

Remyelination in multiple sclerosis: from basic science to clinical translation

(2020) Catherine Lubetzki et al.   LANCET NEUROLOGY

Microglia phagocytose myelin sheaths to modify developmental myelination

(2020) Alexandria N. Hughes et al.   NATURE NEUROSCIENCE

A prospective harmonized multicentre DTI study of cerebral white matter degeneration in ALS

(2020) Sanjay Kalra et al.   NEUROLOGY

The Role of Astrocytes in Remyelination

(2020) Khalil S. Rawji et al.   TRENDS IN NEUROSCIENCES

Unraveling Myelin Plasticity

(2020) Giulia Bonetto et al.   Frontiers in Cellular Neuroscience

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

(2020) Kevin A. Guttenplan et al.   Nature Communications

Δ 9 ‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

(2020) Alba Huerga‐Gómez et al.   GLIA

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Bruce A C Cree et al.   LANCET NEUROLOGY

Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis

(2020) Gregory T. Carter et al.   MUSCLE & NERVE

Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia

(2020) Jing Wang et al.   NEURON

Lipids in regulating oligodendrocyte structure and function

(2020) Laura Montani   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

(2020) Robin J.M. Franklin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuronal activity-dependent myelin repair promotes motor function recovery after contusion spinal cord injury

(2020) Meiling Luo et al.   BRAIN RESEARCH BULLETIN

Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis

(2020) Stefano Raffaele et al.   MOLECULAR THERAPY

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

(2020) Stefan A. Berghoff et al.   NATURE NEUROSCIENCE

Improving clinical trial outcomes in amyotrophic lateral sclerosis

(2020) Matthew C. Kiernan et al.   Nature Reviews Neurology

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

(2020) Elisa M. Floriddia et al.   Nature Communications

Crossing boundaries: Interplay between the immune system and oligodendrocyte lineage cells

(2020) Leslie Kirby et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?

(2019) Peter Hoch-Kraft et al.   NEUROCHEMICAL RESEARCH

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors

(2019) Kelsey A. Rankin et al.   JOURNAL OF NEUROSCIENCE

White matter changes in the perforant path area in patients with amyotrophic lateral sclerosis

(2019) J. Mollink et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

(2019) Paolo Gelosa et al.   PHARMACOLOGICAL RESEARCH

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

(2019) Rhonda R. Voskuhl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

(2019) Samantha K. Barton et al.   Frontiers in Molecular Neuroscience

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis

(2019) Suhyun Kim et al.   GLIA

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Myelin in the Central Nervous System: Structure, Function, and Pathology

(2019) Christine Stadelmann et al.   PHYSIOLOGICAL REVIEWS

Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD)

(2019) Thomas Meyer et al.   BMC Neurology

NG2 glia are required for maintaining microglia homeostatic state

(2019) Yingjun Liu et al.   GLIA

Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity

(2019) Daisuke Kato et al.   GLIA

The Molecular Basis for Remyelination Failure in Multiple Sclerosis

(2019) Joel Gruchot et al.   Cells

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

(2019) Shu-zhen Zhang et al.   BMC Medicine

Stem cell derived oligodendrocytes to study myelin diseases

(2019) Konstantina Chanoumidou et al.   GLIA

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

(2019) Leslie Kirby et al.   Nature Communications

Identifying potential targets for prevention and treatment of amyotrophic lateral sclerosis based on a screen of medicare prescription drugs

(2019) Ruth M. Pfeiffer et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Immune cell modulation of oligodendrocyte lineage cells

(2019) Emily P. Harrington et al.   NEUROSCIENCE LETTERS

Energy metabolism in ALS: an underappreciated opportunity?

(2018) Tijs Vandoorne et al.   ACTA NEUROPATHOLOGICA

Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice

(2018) Rodolfo G. Gatto et al.   BRAIN RESEARCH

Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis

(2018) Francisco Espejo-Porras et al.   BRITISH JOURNAL OF PHARMACOLOGY

MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study

(2018) Ayman Tourbah et al.   CNS DRUGS

Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination

(2018) Giusy T. Coppolino et al.   GLIA

Effect of Notch1 gene on remyelination in multiple sclerosis in mouse models of acute demyelination

(2018) Hua Fan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

(2018) Antonio Vallarola et al.   Journal of Neuroinflammation

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

(2018) Matthew A. White et al.   NATURE NEUROSCIENCE

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1 G93A mice

(2018) Caroline Eykens et al.   NEUROBIOLOGY OF AGING

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

(2018) Maria B. Goncalves et al.   NEUROBIOLOGY OF DISEASE

Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress

(2018) Hajime Takase et al.   NEUROSCIENCE LETTERS

How to reprogram microglia toward beneficial functions

(2018) Marta Fumagalli et al.   GLIA

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Oligodendrocyte Bioenergetics in Health and Disease

(2018) Lauren Rosko et al.   NEUROSCIENTIST

Inflammation in ALS/FTD pathogenesis

(2018) Madelyn E. McCauley et al.   ACTA NEUROPATHOLOGICA

A pilot trial of RNS60 in amyotrophic lateral sclerosis

(2018) Sabrina Paganoni et al.   MUSCLE & NERVE

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination

(2018) Jia Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of myelin structure and conduction velocity by perinodal astrocytes

(2018) Dipankar J. Dutta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Endocannabinoid System and Oligodendrocytes in Health and Disease

(2018) Alexander A. Ilyasov et al.   Frontiers in Neuroscience

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination

(2017) Veronique E. Miron   JOURNAL OF LEUKOCYTE BIOLOGY

Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α

(2017) Goutam Chandra et al.   Journal of Neuroimmune Pharmacology

Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation

(2017) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

2-arachidonoylglycerol reduces proteoglycans and enhances remyelination in a progressive model of demyelination

(2017) A Feliu et al.   JOURNAL OF NEUROSCIENCE

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Pain in amyotrophic lateral sclerosis

(2017) Adriano Chiò et al.   LANCET NEUROLOGY

Metabolic defects in multiple sclerosis

(2017) Reginald C. Adiele et al.   MITOCHONDRION

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

(2017) Carolina Cunha et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis

(2017) Malabendu Jana et al.   NEUROCHEMICAL RESEARCH

Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy

(2017) Susanta Mondal et al.   NEUROCHEMICAL RESEARCH

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms

(2017) Andrea Markovinovic et al.   PROGRESS IN NEUROBIOLOGY

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

(2017) Stefan A. Berghoff et al.   Nature Communications

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

(2017) Jia Liu et al.   Frontiers in Immunology

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials

(2017) C. Eleuteri et al.   Scientific Reports

The immunomodulatory oligodendrocyte

(2016) Thomas Zeis et al.   BRAIN RESEARCH

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Connexin-based channels contribute to metabolic pathways in the oligodendroglial lineage

(2016) Jianqin Niu et al.   JOURNAL OF CELL SCIENCE

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

(2016) Savina Apolloni et al.   Journal of Neuroinflammation

Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice

(2016) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination

(2016) Z. Ou et al.   JOURNAL OF NEUROSCIENCE

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

(2016) Frédéric Sedel et al.   NEUROPHARMACOLOGY

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

(2016) Laura Ferraiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Pushing Forward: Remyelination as the New Frontier in CNS Diseases

(2016) David Kremer et al.   TRENDS IN NEUROSCIENCES

Potential Benefit of the Charge-Stabilized Nanostructure Saline RNS60 for Myelin Maintenance and Repair

(2016) Vijayaraghava T. S. Rao et al.   Scientific Reports

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

(2016) Ryoko Takeuchi et al.   Acta Neuropathologica Communications

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system

(2016) Ginez A. Gonzalez et al.   Scientific Reports

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

(2015) Marta Fumagalli et al.   GLIA

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

(2015) Alerie Guzman de la Fuente et al.   JOURNAL OF CELL BIOLOGY

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders

(2015) Francisco Espejo-Porras et al.   Journal of Neuroimmune Pharmacology

Mechanisms of Oxidase and Superoxide Dismutation-like Activities of Gold, Silver, Platinum, and Palladium, and Their Alloys: A General Way to the Activation of Molecular Oxygen

(2015) Xiaomei Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Familial Amyotrophic Lateral Sclerosis

(2015) Kevin Boylan   NEUROLOGIC CLINICS

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Neuroprotective Effect of Bexarotene in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2015) Javier Riancho et al.   Frontiers in Cellular Neuroscience

Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System

(2015) Ben Emery et al.   Cold Spring Harbor Perspectives in Biology

Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination

(2015) Zhifang Li et al.   Neuroscience Bulletin

High doses of biotin in chronic progressive multiple sclerosis: A pilot study

(2015) Frédéric Sedel et al.   Multiple Sclerosis and Related Disorders

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

(2014) Johannes Brettschneider et al.   ACTA NEUROPATHOLOGICA

Nano-Gold as Artificial Enzymes: Hidden Talents

(2014) Youhui Lin et al.   ADVANCED MATERIALS

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Does GRK–β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?

(2014) Simona Daniele et al.   CELLULAR SIGNALLING

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oligodendrocyte Gap Junction Loss and Disconnection From Reactive Astrocytes in Multiple Sclerosis Gray Matter

(2014) Kyriaki Markoullis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2014) Savina Apolloni et al.   MOLECULAR NEUROBIOLOGY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Neurobiology of premature brain injury

(2014) Natalina Salmaso et al.   NATURE NEUROSCIENCE

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease

(2014) Khushbu K. Modi et al.   PLoS One

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Oligodendrogenesis in the normal and pathological central nervous system

(2014) Bilal El Waly et al.   Frontiers in Neuroscience

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

(2013) Thomas Philips et al.   BRAIN

The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy

(2013) Nikolaus Berndt et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Axonal selection and myelin sheath generation in the central nervous system

(2013) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

Protection of Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease by a Physically-Modified Saline Containing Charge-Stabilized Nanobubbles

(2013) Saurabh Khasnavis et al.   Journal of Neuroimmune Pharmacology

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

Oligodendroglia: metabolic supporters of axons

(2013) Brett M. Morrison et al.   TRENDS IN CELL BIOLOGY

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

(2012) Kyriaki Markoullis et al.   ACTA NEUROPATHOLOGICA

Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

(2012) Weiwei He et al.   BIOMATERIALS

WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination

(2012) Jing Sun et al.   BRAIN RESEARCH

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis

(2012) Kyriaki Markoullis et al.   GLIA

Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline

(2012) Saurabh Khasnavis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Protection of Tregs, Suppression of Th1 and Th17 Cells, and Amelioration of Experimental Allergic Encephalomyelitis by a Physically-Modified Saline

(2012) Susanta Mondal et al.   PLoS One

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage

(2011) Enrica Boda et al.   GLIA

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

(2011) William A. Tyler et al.   GLIA

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dorsally and Ventrally Derived Oligodendrocytes Have Similar Electrical Properties but Myelinate Preferred Tracts

(2011) R. B. Tripathi et al.   JOURNAL OF NEUROSCIENCE

Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands

(2011) S. Daniele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis

(2010) Silvia Rossi et al.   EXPERIMENTAL NEUROLOGY

Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death

(2010) Stefania Ceruti et al.   GLIA

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

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(2010) B. Emery   SCIENCE

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Oxidative stress disrupts oligodendrocyte maturation

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The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

(2009) Yueting Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

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The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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