Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice

(2016) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Retinoids and motor neuron disease: Potential role in amyotrophic lateral sclerosis

(2016) Javier Riancho et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Presymptomatic ALS genetic counseling and testing

(2016) Michael Benatar et al.   NEUROLOGY

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior

(2016) Edward Beamer et al.   NEUROPHARMACOLOGY

Purinergic contribution to amyotrophic lateral sclerosis

(2016) Cinzia Volonté et al.   NEUROPHARMACOLOGY

Neuronal histamine and cognitive symptoms in Alzheimer's disease

(2016) Armin Zlomuzica et al.   NEUROPHARMACOLOGY

Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice

(2016) Kuo-Wei Hsueh et al.   NEUROPHARMACOLOGY

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Cocaine-mediated microglial activation involves the ER stress-autophagy axis

(2015) Ming-Lei Guo et al.   Autophagy

Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

(2015) Annette Masuch et al.   GLIA

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(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

“Preconditioning” with latrepirdine, an adenosine 5′-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1G93A mice

(2015) Karen S. Coughlan et al.   NEUROBIOLOGY OF AGING

The human histaminergic system in neuropsychiatric disorders

(2015) Ling Shan et al.   TRENDS IN NEUROSCIENCES

Neuroprotective Effect of Bexarotene in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2015) Javier Riancho et al.   Frontiers in Cellular Neuroscience

Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis

(2015) Sheng Chen et al.   Neuroscience Bulletin

Altered macroautophagy in the spinal cord of SOD1 mutant mice

(2014) Liang Li et al.   Autophagy

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis

(2014) Xiaojie Zhang et al.   Autophagy

Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2014) Savina Apolloni et al.   MOLECULAR NEUROBIOLOGY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

(2014) Steve Vucic et al.   TRENDS IN NEUROSCIENCES

Why should autophagic flux be assessed?

(2013) Xiao-jie Zhang et al.   ACTA PHARMACOLOGICA SINICA

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

P2X4 receptors control the fate and survival of activated microglia

(2013) Nuria Vázquez-Villoldo et al.   GLIA

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2013) S. Apolloni et al.   HUMAN MOLECULAR GENETICS

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents

(2013) Y. E. Karapetyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

(2012) R. Tesla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H1-antihistamines induce vacuolation in astrocytes through macroautophagy

(2012) Wei-Wei Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms

(2011) Francesca Nicolau-Galmés et al.   APOPTOSIS

Targeting autophagy in ALS: A complex mission

(2011) Melissa Nassif et al.   Autophagy

In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis

(2011) FengFeng Tian et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

(2011) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dimebon Slows Progression of Proteinopathy in γ-Synuclein Transgenic Mice

(2011) Sergey O. Bachurin et al.   NEUROTOXICITY RESEARCH

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

(2010) A. Florence Keller et al.   EXPERIMENTAL NEUROLOGY

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

(2009) Chiara Pizzasegola et al.   Amyotrophic Lateral Sclerosis

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: Possible origin of pharmacological distortions and side effects

(2008) G MORISSETTE et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY