Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review

(2019) Mohaddeseh Sadat Alavi et al.   LIFE SCIENCES

Nuclear G-protein-coupled receptors as putative novel pharmacological targets

(2019) Rita Ribeiro-Oliveira et al.   DRUG DISCOVERY TODAY

Gpr17, a Player in Lysolecithin-Induced Demyelination, Oligodendrocyte Survival, and Differentiation

(2017) Maryam Sadat Seyedsadr et al.   JOURNAL OF NEUROSCIENCE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors

(2017) Reinhard Grisshammer   PROTEIN SCIENCE

The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke

(2017) Elisabetta Bonfanti et al.   Cell Death & Disease

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

(2017) Natalia Platonova et al.   PLoS One

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights

(2016) Chiara Parravicini et al.   CELLULAR SIGNALLING

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance

(2015) Nicolas Bocquet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surface Plasmon Resonance (SPR) Biosensors in Pharmaceutical Analysis

(2015) Andreea Olaru et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

(2015) Marta Fumagalli et al.   GLIA

Two disparate ligand-binding sites in the human P2Y1 receptor

(2015) Dandan Zhang et al.   NATURE

Large-scale production and protein engineering of G protein-coupled receptors for structural studies

(2015) Dalibor Milić et al.   Frontiers in Pharmacology

Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation

(2014) Cristina Sensi et al.   CELLULAR SIGNALLING

Kinetics of the early events of GPCR signalling

(2014) Roslin J. Adamson et al.   FEBS LETTERS

Agonist-bound structure of the human P2Y12 receptor

(2014) Jin Zhang et al.   NATURE

A Computational Approach to Evaluate the Androgenic Affinity of Iprodione, Procymidone, Vinclozolin and Their Metabolites

(2014) Corrado Lodovico Galli et al.   PLoS One

Capture-stabilize approach for membrane protein SPR assays

(2014) Ruiyin Chu et al.   Scientific Reports

Unlocking the secrets of the gatekeeper: Methods for stabilizing and crystallizing GPCRs

(2013) Nicolas Bertheleme et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee

(2012) Jia-Ming Chang et al.   BMC BIOINFORMATICS

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases

(2011) Ivano Eberini et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

(2010) Anna Lundquist et al.   ANALYTICAL BIOCHEMISTRY

Biacore analysis with stabilized G-protein-coupled receptors

(2010) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Nanodiscs allow the use of integral membrane proteins as analytes in surface plasmon resonance studies

(2010) Julian M. Glück et al.   ANALYTICAL BIOCHEMISTRY

Frontal Affinity Chromatography−Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor

(2010) Enrica Calleri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sf9 cells: A versatile model system to investigate the pharmacological properties of G protein-coupled receptors

(2010) Erich H. Schneider et al.   PHARMACOLOGY & THERAPEUTICS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

(2010) Chiara Parravicini et al.   BMC STRUCTURAL BIOLOGY

Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins

(2009) Jennifer A. Maynard et al.   Biotechnology Journal

GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors

(2008) Chiara Parravicini et al.   BMC BIOINFORMATICS

Computational and experimental approaches assess the interactions between bovine β-lactoglobulin and synthetic compounds of pharmacological interest

(2007) Ivano Eberini et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING