Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence

(2015) Yonggang Ma et al.   CARDIOVASCULAR RESEARCH

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

(2015) María P. Menéndez-Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis

(2014) Eimear Linehan et al.   AGING CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

The translational biology of remyelination: Past, present, and future

(2014) Robin J. M. Franklin et al.   GLIA

Expansion and preferential activation of the CD14+ CD16+ monocyte subset during multiple sclerosis

(2014) Delgertsetseg Chuluundorj et al.   IMMUNOLOGY AND CELL BIOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

(2014) Olga Ciccarelli et al.   LANCET NEUROLOGY

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

(2014) Alberto Ascherio et al.   JAMA Neurology

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

(2013) G Majai et al.   LUPUS

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

(2013) Liliane Fossati-Jimack et al.   PLoS One

Retinoid X receptors in macrophage biology

(2013) Tamás Rőszer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response

(2012) Laszlo Nagy et al.   PHYSIOLOGICAL REVIEWS

Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation

(2012) Jeroen F. J. Bogie et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

(2011) Y. A. Syed et al.   JOURNAL OF NEUROSCIENCE

Aging Is Associated With a Shift of Fatty Metabolism Toward Lipogenesis

(2011) A. Kuhla et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenetic regulation by RARα maintains ligand-independent transcriptional activity

(2011) Kristian B. Laursen et al.   NUCLEIC ACIDS RESEARCH

Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock

(2011) Leonhard Schreiner et al.   Journal of Cell Communication and Signaling

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors

(2010) Michael E. Baker   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Retinoid X receptor   controls innate inflammatory responses through the up-regulation of chemokine expression

(2010) V. Nunez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

(2009) Alexandra S. Baer et al.   BRAIN

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE