The Molecular Basis for Remyelination Failure in Multiple Sclerosis

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation

(2019) Sarah C. Starossom et al.   Nature Communications

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

(2019) Alexandra M. Nicaise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Remyelination in multiple sclerosis

(2019) David Kremer et al.   CURRENT OPINION IN NEUROLOGY

Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?

(2019) Sarah Foerster et al.   GLIA

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination

(2019) Wenfei Kang et al.   Stem Cell Reports

MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions

(2018) Peng Wang et al.   GLIA

Effects of inflammatory cytokines IFN-γ, TNF-α and IL-6 on the viability and functionality of human pluripotent stem cell-derived neural cells

(2018) Sanna Hagman et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis and cognition: synaptic failure and network dysfunction

(2018) Massimiliano Di Filippo et al.   NATURE REVIEWS NEUROSCIENCE

Drug repurposing for neuroregeneration in multiple sclerosis

(2018) Peter Göttle et al.   Neural Regeneration Research

Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia

(2018) Fei Wang et al.   NEURON

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

The adult oligodendrocyte can participate in remyelination

(2018) Ian D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis

(2018) Shogo Tanabe et al.   Cell Death & Disease

Neural precursor cell–secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity

(2017) Donatella De Feo et al.   JOURNAL OF CLINICAL INVESTIGATION

Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents

(2017) Evangelia Kesidou et al.   Journal of Neuroinflammation

Cortical Remyelination Is Heterogeneous in Multiple Sclerosis

(2017) Eva M.M. Strijbis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Heterogeneous populations of neural stem cells contribute to myelin repair

(2017) Patrick Küry et al.   Neural Regeneration Research

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

(2017) Natalia Robledinos-Antón et al.   Redox Biology

Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB

(2016) Chiara Rolando et al.   Cell Stem Cell

Pbx1 is required for adult subventricular zone neurogenesis

(2016) Britta Moyo Grebbin et al.   DEVELOPMENT

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation

(2016) David Kremer et al.   PLoS One

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

(2016) Eva C. Bunk et al.   STEM CELLS

Pushing Forward: Remyelination as the New Frontier in CNS Diseases

(2016) David Kremer et al.   TRENDS IN NEUROSCIENCES

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts

(2016) Christin Weissleder et al.   Frontiers in Aging Neuroscience

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells

(2015) Lisa Arvidsson et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

(2015) Jayshree Samanta et al.   NATURE

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

(2015) Gerald J Sun et al.   NATURE NEUROSCIENCE

Loss of NFIX Transcription Factor Biases Postnatal Neural Stem/Progenitor Cells Toward Oligodendrogenesis

(2015) Bo Zhou et al.   STEM CELLS AND DEVELOPMENT

Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis

(2015) Elena Demicheva et al.   Cell Reports

Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury

(2015) Simon M.G. Braun et al.   Cell Reports

Subcutaneous Transplantation of Neural Precursor Cells in Experimental Autoimmune Encephalomyelitis Reduces Chemotactic Signals in the Central Nervous System

(2015) Stylianos Ravanidis et al.   Stem Cells Translational Medicine

Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain

(2015) B. Brousse et al.   Biology Open

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

GSK3β regulates oligodendrogenesis in the dorsal microdomain of the subventricular zone via Wnt-β-catenin signaling

(2014) Kasum Azim et al.   GLIA

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus

(2014) S Chetty et al.   MOLECULAR PSYCHIATRY

A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

(2014) Tobias Derfuss et al.   Multiple Sclerosis Journal

Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis

(2014) M. L. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling through three chemokine receptors triggers the migration of transplanted neural precursor cells in a model of multiple sclerosis

(2014) Mikhal E. Cohen et al.   Stem Cell Research

Persistent Wnt/β-Catenin Signaling Determines Dorsalization of the Postnatal Subventricular Zone and Neural Stem Cell Specification into Oligodendrocytes and Glutamatergic Neurons

(2014) Kasum Azim et al.   STEM CELLS

Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic

(2013) Sha Mi et al.   CNS DRUGS

Mobilization of progenitors in the subventricular zone to undergo oligodendrogenesis in the Theiler's virus model of multiple sclerosis: Implications for remyelination at lesions sites

(2013) M. Mecha et al.   EXPERIMENTAL NEUROLOGY

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

(2013) Felipe Ortega et al.   NATURE CELL BIOLOGY

Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain

(2013) Victoria A. Rafalski et al.   NATURE CELL BIOLOGY

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging

(2013) Vivian Capilla-Gonzalez et al.   Frontiers in Cellular Neuroscience

Cortical remyelination: A new target for repair therapies in multiple sclerosis

(2012) Ansi Chang et al.   ANNALS OF NEUROLOGY

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

p57kip2 regulates glial fate decision in adult neural stem cells

(2012) J. J. Jadasz et al.   DEVELOPMENT

Galectin-4, a novel neuronal regulator of myelination

(2012) Mirjana Stancic et al.   GLIA

The Age of Olfactory Bulb Neurons in Humans

(2012) Olaf Bergmann et al.   NEURON

The complex world of oligodendroglial differentiation inhibitors

(2011) David Kremer et al.   ANNALS OF NEUROLOGY

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

(2011) Gabrièle Piaton et al.   BRAIN

Enhancing remyelination in disease--can we wrap it up?

(2011) M. R. Kotter et al.   BRAIN

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function

(2011) L A Pasquini et al.   CELL DEATH AND DIFFERENTIATION

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

(2011) Jason G Weinger et al.   Journal of Neuroinflammation

Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions

(2011) X. Pedre et al.   JOURNAL OF NEUROSCIENCE

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

(2011) Rieko Muramatsu et al.   NATURE MEDICINE

Increased Spontaneous Apoptosis of Rat Primary Neurospheres In Vitro After Experimental Autoimmune Encephalomyelitis

(2011) Mir Sajad et al.   NEUROCHEMICAL RESEARCH

NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale

(2011) A. Delekate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

(2011) O. Karalay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Stem Cells Prime Proliferating Adult Neural Progenitors Toward an Oligodendrocyte Fate

(2011) Carolin Steffenhagen et al.   STEM CELLS AND DEVELOPMENT

Activation of CXCR7 receptor promotes oligodendroglial cell maturation

(2010) Peter Göttle et al.   ANNALS OF NEUROLOGY

Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood

(2010) M. Bouab et al.   NEUROSCIENCE

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

(2010) J. R. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplanted Neural Precursors Enhance Host Brain-Derived Myelin Regeneration

(2009) O. Einstein et al.   JOURNAL OF NEUROSCIENCE

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Deciphering the Oligodendrogenic Program of Neural Progenitors: Cell Intrinsic and Extrinsic Regulators

(2009) Francisco J. Rivera et al.   STEM CELLS AND DEVELOPMENT

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Statin treatment of adult human glial progenitors induces PPARγ-mediated oligodendrocytic differentiation

(2008) Fraser J. Sim et al.   GLIA

Specific developmental reductions in subventricular zone ErbB1 and ErbB4 mRNA in the human brain

(2008) Victor Z. Chong et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Directed differentiation of hippocampal stem/progenitor cells in the adult brain

(2008) Sebastian Jessberger et al.   NATURE NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE