Regulation and signaling of the GPR17 receptor in oligodendroglial cells

Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

(2020) Davide Capelli et al.   Frontiers in Chemistry

A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism

(2019) Zhimin Ou et al.   Cell Reports

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

(2019) Sebastián Vejar et al.   Frontiers in Cellular Neuroscience

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

(2019) Roberta Brambilla   ACTA NEUROPATHOLOGICA

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

(2019) Paolo Gelosa et al.   PHARMACOLOGICAL RESEARCH

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

GPR17 is an essential regulator for the temporal adaptation of sonic hedgehog signalling in neural tube development

(2019) Atsuki Yatsuzuka et al.   DEVELOPMENT

MicroRNAs change the games in central nervous system pharmacology

(2019) Davide Marangon et al.   BIOCHEMICAL PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17

(2019) Thanigaimalai Pillaiyar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oligodendrocytes express synaptic proteins that modulate myelin sheath formation

(2019) Alexandria N. Hughes et al.   Nature Communications

Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination

(2018) Giusy T. Coppolino et al.   GLIA

G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models

(2018) Stella Nyamoya et al.   MOLECULAR NEUROBIOLOGY

New Insights into Modes of GPCR Activation

(2018) Wenjing Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination

(2018) Changqing Lu et al.   Scientific Reports

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8

(2018) Corentine Marie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

(2018) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

D‐Aspartate treatment attenuates myelin damage and stimulates myelin repair

(2018) Valeria de Rosa et al.   EMBO Molecular Medicine

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Axoglial Adhesion by Cadm4 Regulates CNS Myelination

(2018) Nimrod Elazar et al.   NEURON

Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases

(2017) Paolo Gelosa et al.   MEDIATORS OF INFLAMMATION

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes

(2017) Katharina Simon et al.   MOLECULAR PHARMACOLOGY

The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke

(2017) Elisabetta Bonfanti et al.   Cell Death & Disease

NG2, a common denominator for neuroinflammation, blood–brain barrier alteration, and oligodendrocyte precursor response in EAE, plays a role in dendritic cell activation

(2016) Giovanni Ferrara et al.   ACTA NEUROPATHOLOGICA

Current trends in oxysterol research

(2016) William J. Griffiths et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights

(2016) Chiara Parravicini et al.   CELLULAR SIGNALLING

SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation

(2016) Veronica Meraviglia et al.   GLIA

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination

(2016) Z. Ou et al.   JOURNAL OF NEUROSCIENCE

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin

(2015) Hongxia Ren et al.   DIABETES

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

(2015) Marta Fumagalli et al.   GLIA

GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury

(2015) Francesca Viganò et al.   GLIA

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

(2015) Julia Marschallinger et al.   Nature Communications

Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation

(2014) Cristina Sensi et al.   CELLULAR SIGNALLING

Does GRK–β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?

(2014) Simona Daniele et al.   CELLULAR SIGNALLING

The role of the immune system in central nervous system plasticity after acute injury

(2014) L. Peruzzotti-Jametti et al.   NEUROSCIENCE

Neuronal activity promotes myelination via a cAMP pathway

(2013) Misti Malone et al.   GLIA

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

UDP-glucose enhances outward K+currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors

(2013) Elisabetta Coppi et al.   GLIA

The Regulated Expression, Intracellular Trafficking, and Membrane Recycling of the P2Y-like Receptor GPR17 in Oli-neu Oligodendroglial Cells

(2013) Alessandra Fratangeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4Ligand

(2013) Yoshihide Kanaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination

(2013) H. Nakatani et al.   JOURNAL OF NEUROSCIENCE

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

Cellular and Molecular Characterization of Multipolar Map5-Expressing Cells: A Subset of Newly Generated, Stage-Specific Parenchymal Cells in the Mammalian Central Nervous System

(2013) Paola Crociara et al.   PLoS One

Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key

(2013) V. Joachim Haupt et al.   PLoS One

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

(2013) Heike Franke et al.   Purinergic Signalling

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

Coordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues

(2013) Li He et al.   Neuroscience Bulletin

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

(2012) Hongxia Ren et al.   CELL

The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage

(2011) Enrica Boda et al.   GLIA

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

(2011) William A. Tyler et al.   GLIA

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases

(2011) Ivano Eberini et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands

(2011) S. Daniele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats

(2011) B. Zhao et al.   NEUROSCIENCE

Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

(2010) T Benned-Jensen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death

(2010) Stefania Ceruti et al.   GLIA

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

(2009) Stefania Ceruti et al.   BRAIN

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4

(2009) Akiko Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation

(2008) Davide Lecca et al.   BIOCHEMICAL PHARMACOLOGY

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One