Stem cell derived oligodendrocytes to study myelin diseases

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Drug screening for human genetic diseases using iPSC models

(2018) Matthew S Elitt et al.   HUMAN MOLECULAR GENETICS

Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells

(2018) R. Ross Welliver et al.   JOURNAL OF NEUROSCIENCE

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

(2018) Femke M. de Vrij et al.   MOLECULAR PSYCHIATRY

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

(2018) Seda Koyuncu et al.   Nature Communications

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

(2018) Juan Antonio García-León et al.   Stem Cell Reports

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease

(2018) Li Li et al.   Cell Stem Cell

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

(2018) Sueli Marques et al.   DEVELOPMENTAL CELL

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation

(2018) Mikhail Osipovitch et al.   Cell Stem Cell

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium

(2018) Bernt Popp et al.   Scientific Reports

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

(2018) Donna L. McPhie et al.   Translational Psychiatry

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Achievements and obstacles of remyelinating therapies in multiple sclerosis

(2017) Martin Stangel et al.   Nature Reviews Neurology

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

(2017) I. Micu et al.   NATURE REVIEWS NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

(2017) Marc Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells: Preclinical Efficacy and Safety in Cervical Spinal Cord Injury

(2017) Nathan C. Manley et al.   Stem Cells Translational Medicine

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

(2017) Daniel Scott Himmelstein et al.   eLife

Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes

(2017) Matthias Pawlowski et al.   Stem Cell Reports

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

(2016) Elena Matsa et al.   Cell Stem Cell

Glial progenitor cell-based treatment of the childhood leukodystrophies

(2016) M. Joana Osorio et al.   EXPERIMENTAL NEUROLOGY

Targeting human oligodendrocyte progenitors for myelin repair

(2016) Karen C. Dietz et al.   EXPERIMENTAL NEUROLOGY

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

(2016) Laura Ferraiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation

(2016) Ankshita Prasad et al.   Regenerative Medicine

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease

(2016) M. Joana Osorio et al.   STEM CELLS

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

(2016) Matthew R. Livesey et al.   STEM CELLS

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation

(2015) Jinghua Piao et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice

(2015) Sabah Mozafari et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease

(2015) Antoine Marteyn et al.   STEM CELLS

Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

(2015) Liqun Wang et al.   Nature Communications

Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

(2015) Shingo Miyata et al.   Biomed Research International

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

(2015) Marc Ehrlich et al.   Stem Cell Reports

Induction of Oligodendrocyte Differentiation and In Vitro Myelination by Inhibition of Rho-Associated Kinase

(2014) Carlos E. Pedraza et al.   ASN Neuro

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Human oligodendrocytes in remyelination research

(2014) Marcin Czepiel et al.   GLIA

A Competitive Advantage by Neonatally Engrafted Human Glial Progenitors Yields Mice Whose Brains Are Chimeric for Human Glia

(2014) M. S. Windrem et al.   JOURNAL OF NEUROSCIENCE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the human brain: when bigger is better

(2014) Michel A. Hofman   Frontiers in Neuroanatomy

Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

(2014) Dominik Sakry et al.   PLOS BIOLOGY

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

(2014) Panagiotis Douvaras et al.   Stem Cell Reports

Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes

(2014) Yuko Numasawa-Kuroiwa et al.   Stem Cell Reports

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Generation of oligodendroglial cells by direct lineage conversion

(2013) Nan Yang et al.   NATURE BIOTECHNOLOGY

Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

(2013) Fadi J Najm et al.   NATURE BIOTECHNOLOGY

Human Embryonic Stem Cell-Derived Oligodendrocytes: Protocols and Perspectives

(2013) Walaa F. Alsanie et al.   STEM CELLS AND DEVELOPMENT

High Yields of Oligodendrocyte Lineage Cells from Human Embryonic Stem Cells at Physiological Oxygen Tensions for Evaluation of Translational Biology

(2013) Sybil R.L. Stacpoole et al.   Stem Cell Reports

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Glial Progenitor Cell-Based Treatment and Modeling of Neurological Disease

(2012) S. A. Goldman et al.   SCIENCE

Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination

(2012) N. Uchida et al.   Science Translational Medicine

Neural Stem Cell Engraftment and Myelination in the Human Brain

(2012) N. Gupta et al.   Science Translational Medicine

Immunomodulation by Transplanted Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors in Experimental Autoimmune Encephalomyelitis

(2012) Heechul Kim et al.   STEM CELLS

Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord

(2011) Delphine Buchet et al.   BRAIN

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells

(2011) Fraser J Sim et al.   NATURE BIOTECHNOLOGY

Human Induced Pluripotent Stem Cells Differentiation into Oligodendrocyte Progenitors and Transplantation in a Rat Model of Optic Chiasm Demyelination

(2011) Alireza Pouya et al.   PLoS One

A xeno-free culturing protocol for pluripotent stem cell-derived oligodendrocyte precursor cell production

(2011) Maria Sundberg et al.   Regenerative Medicine

Efficient Differentiation of Human Embryonic Stem Cells into Oligodendrocyte Progenitors for Application in a Rat Contusion Model of Spinal Cord Injury

(2010) Candace L. Kerr et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Genotype-phenotype correlation in vanishing white matter disease

(2010) H. D. W. van der Lei et al.   NEUROLOGY

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium

(2010) Maria Sundberg et al.   Stem Cell Research

Growth of white matter in the adolescent brain: Myelin or axon?

(2009) Tomáš Paus   BRAIN AND COGNITION

Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways

(2009) V. Ribes et al.   DEVELOPMENT

Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells

(2009) Jung-Eun Gil et al.   FEBS LETTERS

Effect of retinoic acid signaling on Wnt/β-catenin and FGF signaling during body axis extension

(2009) Xianling Zhao et al.   GENE EXPRESSION PATTERNS

Neonatal and adult O4+oligodendrocyte lineage cells display different growth factor responses and different gene expression patterns

(2009) Grace Lin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Directing human neural stem/precursor cells into oligodendrocytes by overexpression of Olig2 transcription factor

(2009) Cécile L. Maire et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Differentiation of human oligodendrocytes from pluripotent stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

Fate determination of adult human glial progenitor cells

(2009) Fraser J. Sim et al.   Neuron Glia Biology

In search of human oligodendroglia for myelin repair

(2009) Delphine Buchet et al.   NEUROSCIENCE LETTERS

Human embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury

(2009) Jason Sharp et al.   STEM CELLS

Neonatal Chimerization with Human Glial Progenitor Cells Can Both Remyelinate and Rescue the Otherwise Lethally Hypomyelinated Shiverer Mouse

(2008) Martha S. Windrem et al.   Cell Stem Cell

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES