Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

LXR Regulation of Brain Cholesterol: From Development to Disease

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Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

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Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

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Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in Theiler's Murine Encephalomyelitis

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Statin Treatment in Multiple Sclerosis: A Systematic Review and Meta-Analysis

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Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions

(2015) Miki Furusho et al.   GLIA

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

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Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

(2015) Alerie Guzman de la Fuente et al.   JOURNAL OF CELL BIOLOGY

The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/ -Catenin Signaling

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Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

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The Fibroblast Growth Factor signaling pathway

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Pivotal role of choline metabolites in remyelination

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Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1

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Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain

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A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis

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Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest, Axon Wrapping, and Myelin Gene Expression

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An adverse lipid profile is associated with disability and progression in disability, in people with MS

(2014) Prudence Tettey et al.   Multiple Sclerosis Journal

Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables

(2014) Simona Vuletic et al.   Multiple Sclerosis and Related Disorders

Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

(2014) Hema Mohan et al.   Acta Neuropathologica Communications

High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System

(2013) Silke Timmermans et al.   Journal of Neuroimmune Pharmacology

Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event

(2013) Bianca Weinstock-Guttman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Limited TCF7L2 Expression in MS Lesions

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Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

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Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth

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IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

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Differential Modulation of the Oligodendrocyte Transcriptome by Sonic Hedgehog and Bone Morphogenetic Protein 4 via Opposing Effects on Histone Acetylation

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Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

(2012) Gesine Saher et al.   NATURE MEDICINE

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

FGF-2 and Anosmin-1 Are Selectively Expressed in Different Types of Multiple Sclerosis Lesions

(2011) D. Clemente et al.   JOURNAL OF NEUROSCIENCE

Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination

(2011) Yong-Xing Zhou et al.   NEUROBIOLOGY OF DISEASE

Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI

(2011) Susann Boretius et al.   NEUROIMAGE

Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

(2011) Andrew J. Steelman et al.   NEUROSCIENCE RESEARCH

Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

(2011) Viktoria Gudi et al.   PLoS One

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Statin Therapy Inhibits Remyelination in the Central Nervous System

(2009) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Myelinated, synapsing cultures of murine spinal cord - validation as anin vitromodel of the central nervous system

(2008) C. E. Thomson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

(2008) L.-A. Harsan et al.   JOURNAL OF NEUROSCIENCE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

(2008) Bastian G. Brinkmann et al.   NEURON

BODIPY-Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms

(2008) Maarit Hölttä-Vuori et al.   TRAFFIC