Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

MicroRNA-125b regulates microglia activation and motor neuron death in ALS

(2016) C Parisi et al.   CELL DEATH AND DIFFERENTIATION

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation

(2016) Kai Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes

(2016) Amitava Das et al.   JOURNAL OF IMMUNOLOGY

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

(2016) Savina Apolloni et al.   Journal of Neuroinflammation

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1

(2016) M. Gravel et al.   JOURNAL OF NEUROSCIENCE

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

(2016) Carolina Cunha et al.   MEDIATORS OF INFLAMMATION

miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair

(2016) J. R. Czochor et al.   MOLECULAR CANCER RESEARCH

Presymptomatic ALS genetic counseling and testing

(2016) Michael Benatar et al.   NEUROLOGY

Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis

(2016) Lucas T. Vu et al.   Neurotherapeutics

Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Tesfaye W. Tefera et al.   PLoS One

A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

(2016) Prajwal Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1

(2016) Xiaoyi Li et al.   Scientific Reports

MicroRNAs: Newcomers into the ALS Picture

(2015) Cinzia Volonte et al.   CNS & Neurological Disorders-Drug Targets

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

(2015) Filipa L Cardoso et al.   Journal of Neuroinflammation

Hemichannels: New pathways for gliotransmitter release

(2015) T.D. Montero et al.   NEUROSCIENCE

Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission

(2015) Filipe Nascimento et al.   Purinergic Signalling

An updated role of microRNA-124 in central nervous system disorders: a review

(2015) Yang Sun et al.   Frontiers in Cellular Neuroscience

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

(2014) Joana R. Guedes et al.   HUMAN MOLECULAR GENETICS

Increased autotaxin activity in multiple sclerosis

(2014) Hamid Zahednasab et al.   JOURNAL OF NEUROIMMUNOLOGY

Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

(2014) G. M. Thomsen et al.   JOURNAL OF NEUROSCIENCE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

CX3CR1 Is a Modifying Gene of Survival and Progression in Amyotrophic Lateral Sclerosis

(2014) Alan Lopez-Lopez et al.   PLoS One

Adenosine A2A Receptors Activation Facilitates Neuromuscular Transmission in the Pre-Symptomatic Phase of the SOD1(G93A) ALS Mice, but Not in the Symptomatic Phase

(2014) Filipe Nascimento et al.   PLoS One

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

(2014) Cristina Limatola et al.   Frontiers in Cellular Neuroscience

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

(2014) Xiaobing He et al.   Biomed Research International

Efficient recovery of proteins from multiple source samples after trizol® or trizol®LS RNA extraction and long-term storage

(2013) André ES Simões et al.   BMC GENOMICS

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

(2013) Erica D. Koval et al.   HUMAN MOLECULAR GENETICS

Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency

(2013) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats

(2013) Maria Nikodemova et al.   NEUROBIOLOGY OF DISEASE

Essential Role of MFG-E8 for Phagocytic Properties of Microglial Cells

(2013) Yong Liu et al.   PLoS One

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

(2013) Mariana C. Rocha et al.   PLoS One

Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases

(2013) Johanna Gaiottino et al.   PLoS One

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels

(2013) Danae Campos-Melo et al.   Molecular Brain

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

(2012) M. Fricker et al.   JOURNAL OF NEUROSCIENCE

Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death

(2012) Masami Suzuki et al.   Molecular Neurodegeneration

Presymptomatic studies in ALS: Rationale, challenges, and approach

(2012) M. Benatar et al.   NEUROLOGY

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

(2012) Reuben Saba et al.   PLoS One

Autotaxin protects microglial cells against oxidative stress

(2011) Rana Awada et al.   FREE RADICAL BIOLOGY AND MEDICINE

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

(2011) Ana L. Cardoso et al.   IMMUNOLOGY

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Astrogliosis in amyotrophic lateral sclerosis: Role and therapeutic potential of astrocytes

(2010) Marcelo R. Vargas et al.   Neurotherapeutics

SED1/MFG-E8: A Bi-Motif protein that orchestrates diverse cellular interactions

(2009) Adam Raymond et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN