Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

Respiratory muscle testing in amyotrophic lateral sclerosis: a practical approach

(2019) Giuseppe F. Sferrazza Papa et al.   MINERVA MEDICA

Effect of pterostilbene on in vitro drug metabolizing enzyme activity

(2019) Ahmed A. Albassam et al.   SAUDI PHARMACEUTICAL JOURNAL

Amyotrophic lateral sclerosis among patients with a Medicare Advantage prescription drug plan; prevalence, survival and patient characteristics

(2019) Rituparna Bhattacharya et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Unique characteristics of the genetics epidemiology of amyotrophic lateral sclerosis in China

(2019) Qianqian Wei et al.   Science China-Life Sciences

The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

(2019) Garrison Dyck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study

(2019) C. F. Dolopikou et al.   EUROPEAN JOURNAL OF NUTRITION

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

(2019) Justine Renaud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Curcumin on Microglial Cells

(2019) Faezeh Ghasemi et al.   NEUROTOXICITY RESEARCH

Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116

(2019) Alison Gowland et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

(2019) Keisuke Hikosaka et al.   NUTRITIONAL NEUROSCIENCE

Radicava (edaravone) for amyotrophic lateral sclerosis: US experience at 1 year after launch

(2019) Carlayne Jackson et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers

(2019) Christian Bailly   INTERNATIONAL IMMUNOPHARMACOLOGY

NAD metabolism: Implications in aging and longevity

(2018) Keisuke Yaku et al.   AGEING RESEARCH REVIEWS

The Regulatory Role of NAD in Human and Animal Cells

(2018) V. A. Kulikova et al.   BIOCHEMISTRY-MOSCOW

Biomechanistic insights into the roles of oxidative stress in generating complex neurological disorders

(2018) Mohammad Yusuf et al.   BIOLOGICAL CHEMISTRY

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Decreased glutathione levels cause overt motor neuron degeneration in hSOD1 WT over-expressing mice

(2018) Kelby M. Killoy et al.   EXPERIMENTAL NEUROLOGY

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Biological Activities of Stilbenoids

(2018) Bolanle Akinwumi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway

(2018) Qiushi Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

(2018) Kazutoshi Watanabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Postmortem Brain, Cerebrospinal Fluid, and Blood Neurotrophic Factor Levels in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2018) Yang Du et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK

(2018) T.H. Wang et al.   NEUROSCIENCE

Safety and Efficacy of Nanocurcumin as Add-On Therapy to Riluzole in Patients With Amyotrophic Lateral Sclerosis: A Pilot Randomized Clinical Trial

(2018) Mona Ahmadi et al.   Neurotherapeutics

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

(2018) Helena Solleiro-Villavicencio et al.   Frontiers in Cellular Neuroscience

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole

(2018) Moritz Oberstadt et al.   Scientific Reports

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy

(2018) Leila Bond et al.   Frontiers in Neuroscience

Role of ROS and Nutritional Antioxidants in Human Diseases

(2018) Zewen Liu et al.   Frontiers in Physiology

Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

(2018) Cristina Carvalho et al.   Frontiers in Physiology

Neuroinflammation: Microglia and T Cells Get Ready to Tango

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2014

(2018) Paul Mehta et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

A need for NAD+ in muscle development, homeostasis, and aging

(2018) Michelle F. Goody et al.   Skeletal Muscle

Amyotrophic Lateral Sclerosis and Oxidative Stress: a Double-Blind Therapeutic Trial After Curcumin Supplementation

(2018) Lucia Chico et al.   CNS & Neurological Disorders-Drug Targets

Mitochondrial therapeutic interventions in Alzheimer’s disease

(2018) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cellular Proteostasis in Neurodegeneration

(2018) Alberim Kurtishi et al.   MOLECULAR NEUROBIOLOGY

Muscle profile and cognition in patients with Alzheimer’s disease dementia

(2018) Yeonsil Moon et al.   NEUROLOGICAL SCIENCES

ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression

(2018) Yajuan Xiao et al.   PHARMACOLOGICAL RESEARCH

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

(2018) Isabel Formella et al.   Redox Biology

Provincial Differences in the Diagnosis and Care of Amyotrophic Lateral Sclerosis

(2018) Victoria L. Hodgkinson et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Quantum chemical and molecular mechanics studies on the assessment of interactions between resveratrol and mutant SOD1 (G93A) protein

(2018) E. Srinivasan et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Reduced sirtuin 1/adenosine monophosphate‐activated protein kinase in amyotrophic lateral sclerosis patient‐derived mesenchymal stem cells can be restored by resveratrol

(2018) Young Chan Yun et al.   Journal of Tissue Engineering and Regenerative Medicine

Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice

(2018) Christopher G. Wier et al.   MUSCLE & NERVE

Role of Natural Antioxidants from Functional Foods in Neurodegenerative and Metabolic Disorders

(2018) José C. T. Carvalho et al.   Oxidative Medicine and Cellular Longevity

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway

(2018) Giusy Laudati et al.   NEUROTOXICOLOGY

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

(2017) Hideyuki Sawada   EXPERT OPINION ON PHARMACOTHERAPY

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

(2017) Pauline Vaur et al.   FASEB JOURNAL

Oxidative stress in cerebral small vessel disease. Role of reactive species

(2017) Cezary Grochowski et al.   FREE RADICAL RESEARCH

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

(2017) Diane Moujalled et al.   HUMAN MOLECULAR GENETICS

Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

(2017) Xiaojing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polyphenol-Rich Lentils and Their Health Promoting Effects

(2017) Kumar Ganesan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s Disease: Characterization of the Brain Sites of the Initial Tau Cytoskeletal Pathology Will Improve the Success of Novel Immunological Anti-Tau Treatment Approaches

(2017) Udo Rüb et al.   JOURNAL OF ALZHEIMERS DISEASE

Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise

(2017) Anand Thirupathi et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Anti-inflammatory effects of polyphenols in arthritis

(2017) Francesca Oliviero et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Antibacterial Activity of Polyphenols: Structure-Activity Relationship and Influence of Hyperglycemic Condition

(2017) Yixi Xie et al.   MOLECULES

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

(2017) Hanna Bayer et al.   NEUROBIOLOGY OF DISEASE

SIRT3 and mitochondrial metabolism in neurodegenerative diseases

(2017) Illari Salvatori et al.   NEUROCHEMISTRY INTERNATIONAL

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives

(2017) F. Bozzo et al.   NEUROSCIENCE LETTERS

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation

(2017) Clara Minto et al.   NUTRITION REVIEWS

Dietary Polyphenols in the Prevention of Stroke

(2017) A. Tressera-Rimbau et al.   Oxidative Medicine and Cellular Longevity

Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry

(2017) Nayansi Jha et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Anti-inflammatory activity of natural stilbenoids: A review

(2017) Marcela Dvorakova et al.   PHARMACOLOGICAL RESEARCH

Ying and Yang interplay between reactive oxygen and reactive nitrogen species controls cell functions

(2017) Laura De Gara et al.   PLANT CELL AND ENVIRONMENT

Quercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant

(2017) Philbert Ip et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Amyloidogenesis of Tau protein

(2017) Bartosz Nizynski et al.   PROTEIN SCIENCE

The NAD+/PARP1/SIRT1 Axis in Aging

(2017) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis

(2017) Manoj Kumar Jaiswal   Frontiers in Cellular Neuroscience

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

(2017) et al.   Nutrients

Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway

(2017) En-Xing Xue et al.   Oncotarget

Potential therapeutic targets for ALS: MIR206, MIR208b and MIR499 are modulated during disease progression in the skeletal muscle of patients

(2017) Lorena Di Pietro et al.   Scientific Reports

Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability

(2017) Qu Jin et al.   Theranostics

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Evaluating the completeness of the national ALS registry, United States

(2017) Wendy E. Kaye et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Comparison of Sirtuin 3 Levels in ALS and Huntington’s Disease—Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models

(2017) Eva Buck et al.   Frontiers in Molecular Neuroscience

Cysteine Modifications in the Pathogenesis of ALS

(2017) Cristiana Valle et al.   Frontiers in Molecular Neuroscience

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis

(2017) Johannes Dorst et al.   Therapeutic Advances in Neurological Disorders

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

(2017) Rachel S. Fletcher et al.   Molecular Metabolism

Classifying oxidative stress by F 2 -isoprostane levels across human diseases: A meta-analysis

(2017) Thomas J. van 't Erve et al.   Redox Biology

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

(2017) Chehade Karam et al.   Skeletal Muscle

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

(2017) Paula I. Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Pathobiology in Parkinson's Disease and Amyotrophic Lateral Sclerosis

(2017) Lee J. Martin   JOURNAL OF ALZHEIMERS DISEASE

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

(2017) David Gonzalez et al.   PLoS One

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury

(2016) Yedong Cheng et al.   APOPTOSIS

Coenzyme Q10 redox balance and a free radical scavenger drug

(2016) Yorihiro Yamamoto   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NAD + metabolism: Bioenergetics, signaling and manipulation for therapy

(2016) Yue Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

(2016) Elango Bhakkiyalakshmi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer’s disease

(2016) Yuxing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway

(2016) Bodong Wang et al.   BRAIN RESEARCH

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

Panel of Oxidative Stress and Inflammatory Biomarkers in ALS: A Pilot Study

(2016) Hélène Blasco et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Could Sirtuin Activities Modify ALS Onset and Progression?

(2016) Bor Luen Tang   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

(2016) Bhagyashree Naik et al.   Cognitive Neurodynamics

Mitochondrial Biology and Neurological Diseases

(2016) Siddharth Arun et al.   Current Neuropharmacology

Restoration of sirt1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes

(2016) Yan Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence

(2016) Ramoji Kosuru et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pterostilbene as treatment for severe acute pancreatitis

(2016) Y.J. Lin et al.   GENETICS AND MOLECULAR RESEARCH

Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1

(2016) Dan Li et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis

(2016) Benoît Marin et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

From Olive Fruits to Olive Oil: Phenolic Compound Transfer in Six Different Olive Cultivars Grown under the Same Agronomical Conditions

(2016) Nassima Talhaoui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhancing NAD+Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1)

(2016) Benjamin A. Harlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral bioavailability of curcumin: problems and advancements

(2016) Weidong Liu et al.   JOURNAL OF DRUG TARGETING

Clinical tool for predicting survival in ALS: do we need one?

(2016) Kevin Talbot   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

Resveratrol and its methoxy-derivatives as modulators of DNA damage induced by ionising radiation

(2016) Gianandrea Traversi et al.   MUTAGENESIS

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

(2016) D.R. Sharma et al.   NEUROSCIENCE

Role of Natural Stilbenes in the Prevention of Cancer

(2016) J. Antoni Sirerol et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid

(2016) Shailendra P. Singh et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration

(2016) Midori Nagase et al.   REDOX REPORT

Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders

(2016) Showkat Ahmad Ganie et al.   REJUVENATION RESEARCH

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span

(2016) Borut Poljsak et al.   REJUVENATION RESEARCH

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Resveratrol and Cardiovascular Diseases

(2016) Dominique Bonnefont-Rousselot   Nutrients

Anticancer Efficacy of Polyphenols and Their Combinations

(2016) Aleksandra Niedzwiecki et al.   Nutrients

Natural Polyphenols for Prevention and Treatment of Cancer

(2016) Yue Zhou et al.   Nutrients

Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis

(2016) Jeri W. Nieves et al.   JAMA Neurology

Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy?

(2016) T. Michael De Silva et al.   Frontiers in Pharmacology

ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

(2016) Sarah Pickles et al.   Acta Neuropathologica Communications

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Biological and physiological role of reactive oxygen species - the good, the bad and the ugly

(2015) L. Zuo et al.   Acta Physiologica

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

(2015) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol and diabetes: from animal to human studies

(2015) Tomasz Szkudelski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity

(2015) Nidhi K. Bhatia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Mesenchymal stromal cells loading curcumin-INVITE-micelles: A drug delivery system for neurodegenerative diseases

(2015) Giuseppe Tripodo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

(2015) James P. Kehrer et al.   CRITICAL REVIEWS IN TOXICOLOGY

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

(2015) Joel Raskin et al.   Current Alzheimer Research

Identification of phenolic compounds in red wine extract samples and zebrafish embryos by HPLC-ESI-LTQ-Orbitrap-MS

(2015) Anna Vallverdú-Queralt et al.   FOOD CHEMISTRY

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia

(2015) Lihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Humoral factors in ALS patients during disease progression

(2015) Jared Ehrhart et al.   Journal of Neuroinflammation

Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways

(2015) Zhen Song et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antagonistic molecular interactions of photosynthetic pigments with molecular disease targets: a new approach to treat AD and ALS

(2015) R. Navanietha Krishnaraj et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

The sirtuins: Markers of metabolic health

(2015) Jeffrey D. Covington et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carotenoid Metabolism in Plants

(2015) Nazia Nisar et al.   Molecular Plant

DNA damage in neurodegenerative diseases

(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effects of pterostilbene and resveratrol on brain and behavior

(2015) Shibu M. Poulose et al.   NEUROCHEMISTRY INTERNATIONAL

An Assessment of Possible Neuropathology and Clinical Relationships in 46 Sporadic Amyotrophic Lateral Sclerosis Patient Autopsies

(2015) Grant Coan et al.   Neurodegenerative Diseases

Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis

(2015) Richard S. Bedlack et al.   NEUROLOGIC CLINICS

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

(2015) M. Ikawa et al.   NEUROLOGY

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways

(2015) Q. Wang et al.   NEUROSCIENCE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Reactive Oxygen and Nitrogen Species

(2015) Dereck Salisbury et al.   NURSING RESEARCH

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

(2015) Mika Reinisalo et al.   Oxidative Medicine and Cellular Longevity

Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse

(2015) Ken Ikeda et al.   PLoS One

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS

(2015) Maria Teresa Carrì et al.   Frontiers in Cellular Neuroscience

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

(2015) Fabiola Rojas et al.   Frontiers in Cellular Neuroscience

An acetylation switch controls TDP-43 function and aggregation propensity

(2015) Todd J. Cohen et al.   Nature Communications

Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases

(2015) Isha Solanki et al.   Advances in Nutrition

Components of a Mediterranean diet and their impact on cognitive functions in aging

(2015) Sebastian Huhn et al.   Frontiers in Aging Neuroscience

Risk factors for amyotrophic lateral sclerosis

(2015) Fang Fang et al.   Clinical Epidemiology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Role of Energy Metabolic Deficits and Oxidative Stress in Excitotoxic Spinal Motor Neuron Degeneration in Vivo

(2014) Luz Diana Santa-Cruz et al.   ASN Neuro

Decrease in ATP biosynthesis and dysfunction of biological membranes. Two possible key mechanisms of phenoptosis

(2014) A. V. Rzheshevsky   BIOCHEMISTRY-MOSCOW

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis

(2014) Wenzhi Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Linking DNA Damage, NAD + /SIRT1, and Aging

(2014) Leonard Guarente   Cell Metabolism

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway

(2014) Constance Lay Lay Saw et al.   FOOD AND CHEMICAL TOXICOLOGY

A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay

(2014) Anna Vallverdú-Queralt et al.   FOOD CHEMISTRY

Role of melatonin supplementation in neurodegenerative disorders

(2014) Giovanni Polimeni   Frontiers in Bioscience-Landmark

Flavonoids in modulation of cell survival signalling pathways

(2014) Mohammad Lukman Mansuri et al.   Genes and Nutrition

Mitochondrial dysfunction in central nervous system white matter disorders

(2014) Laia Morató et al.   GLIA

Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases ActivitiesIn Vitro

(2014) Zsofia Kutil et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

The Role of Reactive Oxygen Species in Microvascular Remodeling

(2014) Marius Staiculescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects of Pterostilbene against Acetaminophen-Induced Hepatotoxicity in Rats

(2014) El-Sayed M. El-Sayed et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Role of Walnuts in Maintaining Brain Health with Age

(2014) Shibu M. Poulose et al.   JOURNAL OF NUTRITION

Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress

(2014) Bo Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Advances in motor neurone disease

(2014) Dirk Bäumer et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

(2014) Stefania Bulotta et al.   Journal of Translational Medicine

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS

(2014) H. Dong et al.   NEUROSCIENCE

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

(2014) Orhan Tansel Korkmaz et al.   NEUROSCIENCE LETTERS

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

(2014) N. Weiduschat et al.   NEUROSCIENCE LETTERS

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

(2014) Renzo Mancuso et al.   Neurotherapeutics

Dietary intake of fruits and beta-carotene is negatively associated with amyotrophic lateral sclerosis risk in Koreans: A case-control study

(2014) Youri Jin et al.   NUTRITIONAL NEUROSCIENCE

Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?

(2014) Renzo Mancuso et al.   Orphanet Journal of Rare Diseases

Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases

(2014) Elżbieta Miller et al.   Oxidative Medicine and Cellular Longevity

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients

(2014) Annalisa LoGerfo et al.   Oxidative Medicine and Cellular Longevity

Evaluation of the antioxidative properties of lipoxygenase inhibitors

(2014) Grzegorz A. Czapski et al.   Pharmacological Reports

Catalase activity in blood fractions of patients with sporadic ALS

(2014) Aleksandra Golenia et al.   Pharmacological Reports

Environmental Risk Factors and Amyotrophic Lateral Sclerosis (ALS): A Case-Control Study of ALS in Michigan

(2014) Yu Yu et al.   PLoS One

Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1G93A Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

(2014) Mariana Pehar et al.   PLoS One

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

(2014) Yue Hou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD+ Levels

(2014) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective

(2014) Qiu-Yi Choo et al.   Journal of Functional Foods

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients

(2014) Koji Abe et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1G93AMouse Model of Amyotrophic Lateral Sclerosis

(2014) Lin Song et al.   Biomed Research International

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow

(2014) Natasha M. Rogers et al.   Frontiers in Physiology

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation

(2013) Rodrigo M. Cordeiro   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biomarkers of lipid peroxidation in clinical material

(2013) Etsuo Niki   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protective effect of Pterostilbene against free radical mediated oxidative damage

(2013) Jhankar D Acharya et al.   BMC Complementary and Alternative Medicine

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

(2013) Rachele A. Saccon et al.   BRAIN

Adequacy of Niacin, Folate, and Vitamin B12 Intakes from Foods: Among Newfoundland and Labrador Adults

(2013) Jennifer Colbourne et al.   CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH

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(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Scavenging of hydroxyl radical by resveratrol and related natural stilbenes after hydrogen peroxide attack on DNA

(2013) Miriam Rossi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pterostilbene: Biomedical applications

(2013) José M. Estrela et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection

(2013) Yuling Chi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Comprehensive identification of walnut polyphenols by liquid chromatography coupled to linear ion trap–Orbitrap mass spectrometry

(2013) Jorge Regueiro et al.   FOOD CHEMISTRY

Reactive oxygen species and the free radical theory of aging

(2013) Stefan I. Liochev   FREE RADICAL BIOLOGY AND MEDICINE

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

(2013) Emanuele D’Amico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

(2013) S. Pickles et al.   HUMAN MOLECULAR GENETICS

Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

(2013) Jordi Magrané et al.   HUMAN MOLECULAR GENETICS

Oxidative Stress and Neurodegenerative Disorders

(2013) Jie Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stilbenes and Anthocyanins Reduce Stress Signaling in BV-2 Mouse Microglia

(2013) Amanda N. Carey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Recycling Nicotinamide. The Transition-State Structure of Human Nicotinamide Phosphoribosyltransferase

(2013) Emmanuel S. Burgos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

Pharmacokinetics of pterostilbene in Sprague-Dawley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability

(2013) Samuel Chao Ming Yeo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Yi Zhang et al.   NEUROBIOLOGY OF DISEASE

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration

(2013) Efthimios Dardiotis et al.   NEUROSCIENCE LETTERS

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

(2013) Khushwant S. Bhullar et al.   Oxidative Medicine and Cellular Longevity

Redox Regulation in Amyotrophic Lateral Sclerosis

(2013) Sonam Parakh et al.   Oxidative Medicine and Cellular Longevity

ROS and Brain Diseases: The Good, the Bad, and the Ugly

(2013) Aurel Popa-Wagner et al.   Oxidative Medicine and Cellular Longevity

The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

(2013) Katie Richardson et al.   PLoS One

Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Genetic and epigenetic studies of amyotrophic lateral sclerosis

(2013) Ammar Al-Chalabi et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis

(2013) D. Michal Freedman et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Mechanisms, models and biomarkers in amyotrophic lateral sclerosis

(2013) Martin R. Turner et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

Incidence of Amyotrophic Lateral Sclerosis Among American Indians and Alaska Natives

(2013) Paul H. Gordon et al.   JAMA Neurology

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

(2013) Paul Gordon et al.   Aging and Disease

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

(2012) David Porquet et al.   AGE

Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies

(2012) Kathryn C. Fitzgerald et al.   ANNALS OF NEUROLOGY

The Discovery of Niacin, Biotin, and Pantothenic Acid

(2012) Douglas J. Lanska   ANNALS OF NUTRITION AND METABOLISM

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

(2012) Soyoung Han et al.   BRAIN RESEARCH

Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin

(2012) Jinsheng Lu et al.   BRAIN RESEARCH BULLETIN

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions

(2012) A. R. Neves et al.   CURRENT MEDICINAL CHEMISTRY

Extranuclear Localization of SIRT1 and PGC-1α: An Insight into Possible Roles in Diseases Associated with Mitochondrial Dysfunction

(2012) K. Aquilano et al.   CURRENT MOLECULAR MEDICINE

Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARγ and adenosine

(2012) Iryna Voloshyna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

(2012) Mahesh Ramamoorthy et al.   FREE RADICAL BIOLOGY AND MEDICINE

An overview of the chemistry and biology of reactive aldehydes

(2012) Kristofer S. Fritz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

Berry Fruit Enhances Beneficial Signaling in the Brain

(2012) Marshall G. Miller et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae

(2012) Céline Rivière et al.   NATURAL PRODUCT REPORTS

Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?

(2012) Sonja Körner et al.   Neurodegenerative Diseases

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

(2012) Seithikurippu R. Pandi-Perumal et al.   NEUROTOXICITY RESEARCH

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Effects of natural antioxidants in neurodegenerative disease

(2012) Sonia Luz Albarracin et al.   NUTRITIONAL NEUROSCIENCE

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1G93A and SOD1H46R, Exert Distinct Harmful Effects on Gross Phenotype in Mice

(2012) Lei Pan et al.   PLoS One

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

(2012) S. Guareschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of antioxidant enzymes in corpus luteum rescue from reactive oxygen species-induced oxidative stress

(2012) Kaïs H. Al-Gubory et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

A New Definition of Aging?

(2012) Thomas Flatt   Frontiers in Genetics

Vitamin E Intake and Risk of Amyotrophic Lateral Sclerosis: A Pooled Analysis of Data From 5 Prospective Cohort Studies

(2011) H. Wang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

(2011) Marzia Perluigi et al.   ANTIOXIDANTS & REDOX SIGNALING

Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo

(2011) Lu Zhang et al.   APOPTOSIS

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions

(2011) Linnea R. Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity

(2011) Hong Jiang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibition of superoxide dismutase selectively suppresses growth of rat spinal motor neurons: Comparison with phosphorylated neurofilament-containing spinal neurons

(2011) Risa Isonaka et al.   BRAIN RESEARCH

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway

(2011) Sijo J. Thandapilly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Total Phenolic Contents and Antioxidant Capacities of Herbal and Tea Infusions

(2011) Li Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway

(2011) Yi-Siou Chiou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alsin and SOD1G93AProteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity

(2011) Qiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

(2011) Andrey Nikiforov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

(2011) Zsolt Radak et al.   MOLECULAR ASPECTS OF MEDICINE

The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

(2011) Carlos B. Mantilla et al.   MUSCLE & NERVE

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

(2011) Jaewon Chang et al.   NEUROBIOLOGY OF AGING

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis

(2011) L. M. Duffy et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis

(2011) Jing Wang et al.   NEUROSCIENCE LETTERS

Mitochondrial dysfunction in ALS

(2011) Mauro Cozzolino et al.   PROGRESS IN NEUROBIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

(2010) Cynthia A. Massaad et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Radical changes in multiple sclerosis pathogenesis

(2010) Jack van Horssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

(2010) Simonetta Camandola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats

(2010) Izet M. Kapetanovic et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention

(2010) Alyson A. Miller et al.   CLINICAL SCIENCE

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Effects of gender in amyotrophic lateral sclerosis

(2010) Pamela A. McCombe et al.   Gender Medicine

Differential Protection among Fractionated Blueberry Polyphenolic Families against DA-, Aβ42- and LPS-Induced Decrements in Ca2+Buffering in Primary Hippocampal Cells

(2010) James A. Joseph et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

(2010) Jin A. Shin et al.   JOURNAL OF NEUROIMMUNOLOGY

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients

(2010) Emanuela Cova et al.   NEUROCHEMISTRY INTERNATIONAL

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell

(2010) W. Duan et al.   NEUROSCIENCE

Antioxidant Effect of trans-Resveratrol, Pterostilbene, Quercetin and Their Combinations in Human Erythrocytes In Vitro

(2010) Renata Mikstacka et al.   PLANT FOODS FOR HUMAN NUTRITION

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial preconditioning: a potential neuroprotective strategy

(2010) Correia   Frontiers in Aging Neuroscience

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

(2009) Petra Kaufmann et al.   ANNALS OF NEUROLOGY

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Anti-inflammatory Action of Pterostilbene Is Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells

(2009) S. Paul et al.   Cancer Prevention Research

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Dietary Administration of High Doses of Pterostilbene and Quercetin to Mice Is Not Toxic

(2009) M. J. Ruiz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

(2009) Sónia C. Correia et al.   JOURNAL OF NEUROCHEMISTRY

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Dynamic NAD(P)H post-synaptic autofluorescence signals for the assessment of mitochondrial function in a neurodegenerative disease: Monitoring the primary motor cortex of G93A mice, an amyotrophic lateral sclerosis model

(2009) Stefano Loizzo et al.   MITOCHONDRION

Dietary phenolics: chemistry, bioavailability and effects on health

(2009) Alan Crozier et al.   NATURAL PRODUCT REPORTS

Inflammation in ALS and SMA: Sorting out the good from the evil

(2009) Dimitra Papadimitriou et al.   NEUROBIOLOGY OF DISEASE

Fruit and Vegetable Intake and Risk of Amyotrophic Lateral Sclerosis in Japan

(2009) K. Okamoto et al.   NEUROEPIDEMIOLOGY

Promotion of cellular NAD+ anabolism: Therapeutic potential for oxidative stress in ageing and alzheimer’s disease

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Green tea polyphenols attenuate glial swelling and mitochondrial dysfunction following oxygen-glucose deprivation in cultures

(2009) Kiran S. Panickar et al.   NUTRITIONAL NEUROSCIENCE

Theobroma cacao L., the Food of the Gods: A scientific approach beyond myths and claims

(2009) M. Rusconi et al.   PHARMACOLOGICAL RESEARCH

Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes☆

(2008) Mei-Jie Jou   ADVANCED DRUG DELIVERY REVIEWS

Niacin Use and Cutaneous Flushing: Mechanisms and Strategies for Prevention

(2008) Michael H. Davidson   AMERICAN JOURNAL OF CARDIOLOGY

Oxidative stress biomarkers in sporadic ALS

(2008) Hiroshi Mitsumoto et al.   Amyotrophic Lateral Sclerosis

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia

(2008) Ian RA Mackenzie et al.   CURRENT OPINION IN NEUROLOGY

Pterostilbene from Vitis coignetiae protect H2O2-induced inhibition of gap junctional intercellular communication in rat liver cell line

(2008) Ji-Sun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

The neuroprotective potential of flavonoids: a multiplicity of effects

(2008) David Vauzour et al.   Genes and Nutrition

Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation

(2008) Nan Zhong et al.   HUMAN MOLECULAR GENETICS

Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging

(2008) James A. Joseph et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pterostilbene Suppressed Lipopolysaccharide-Induced Up-Expression of iNOS and COX-2 in Murine Macrophages

(2008) Min-Hsiung Pan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

(2008) Maged M. Harraz et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer Disease Pathology As a Host Response

(2008) Rudy J. Castellani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFκB, AP-1, COX-2, and iNOS in mouse epidermis

(2008) Michal Cichocki et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane

(2008) Toni Ahtoniemi et al.   NEUROBIOLOGY OF DISEASE

Oxidant–antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

(2008) G. Nagesh Babu et al.   NEUROCHEMISTRY INTERNATIONAL

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

(2008) Ulrich Dirnagl et al.   NEUROPHARMACOLOGY

Electrons, life and the evolution of Earth's oxygen cycle

(2008) P. G Falkowski et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One

Nicotinic Acid: Pharmacological Effects and Mechanisms of Action

(2007) Andreas Gille et al.   Annual Review of Pharmacology and Toxicology

Mitochondrial mechanisms of estrogen neuroprotection

(2007) James W. Simpkins et al.   BRAIN RESEARCH REVIEWS

Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity

(2007) Connie M. Remsberg et al.   PHYTOTHERAPY RESEARCH

Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels

(2003) Caterina Bendotti et al.   JOURNAL OF NEUROCHEMISTRY