Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

(2020) Md. Ataur Rahman et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway

(2020) Ana Sanches-Silva et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial dysfunction in age‐related metabolic disorders

(2020) Venkateswaran Natarajan et al.   PROTEOMICS

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

(2020) Xin Tan et al.   Frontiers in Pharmacology

Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy

(2020) Haixia Xu et al.   Frontiers in Physiology

Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2

(2020) Pingping Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Glucose as a Major Antioxidant: When, What for and Why It Fails?

(2020) Andriy Cherkas et al.   Antioxidants

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

(2020) Assylzhan Yessenkyzy et al.   Nutrients

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

Activation and targeting of ATG8 protein lipidation

(2020) Sascha Martens et al.   Cell Discovery

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

(2020) Larissa-Nele Schaffert et al.   Brain Sciences

Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate excessive TG accumulation in hepatocytes

(2020) Qun Zhuge et al.   Annals of Palliative Medicine

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

(2020) Humna Bhagani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteotoxicity and Neurodegenerative Diseases

(2020) Clara Ruz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement

(2020) Chenyu Wu et al.   Frontiers in Pharmacology

Flavonoids Identification and Pancreatic Beta-Cell Protective Effect of Lotus Seedpod

(2020) Ming-Shih Lee et al.   Antioxidants

Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes

(2020) Bing-yan Liu et al.   ACTA PHARMACOLOGICA SINICA

Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction

(2020) Wen-Qiao Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effects of quercetin and crocin in the kidneys and liver of obese Sprague-Dawley rats with Type 2 diabetes: Effects of quercetin and crocin on T2DM rats

(2020) Ling-Lin Lai et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson’s Disease

(2020) Rui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

(2020) Shiri Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway

(2020) Shuwen Liu et al.   NEUROCHEMICAL RESEARCH

Apple polyphenol extract alleviates lipid accumulation in free‐fatty‐acid‐exposed HepG2 cells via activating autophagy mediated by SIRT1 / AMPK signaling

(2020) Deming Li et al.   PHYTOTHERAPY RESEARCH

Epigallocatechin-3-Gallate Reduces Visceral Adiposity Partly through the Regulation of Beclin1-Dependent Autophagy in White Adipose Tissues

(2020) Cheoljun Choi et al.   Nutrients

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases

(2020) Tuuli-Maria Sonninen et al.   Cells

Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases

(2020) Aline Yammine et al.   Cells

Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

(2020) Tharindu L. Suraweera et al.   Antioxidants

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

(2020) Fiona Limanaqi et al.   Antioxidants

Quercetin Induces p53‐independent Cancer Cell Death via TFEB‐mediated Lysosome Activation and ROS‐dependent Ferroptosis

(2020) Zi‐Xuan Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

(2020) Javier Checa et al.   Journal of Inflammation Research

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

(2019) Rocío M. de Pablos et al.   PHARMACOLOGICAL RESEARCH

Linking the Endoplasmic Reticulum to Parkinson’s Disease and Alpha-Synucleinopathy

(2019) Emanuela Colla   Frontiers in Neuroscience

α-Arbutin Protects Against Parkinson’s Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo

(2019) Yaqi Ding et al.   NEUROMOLECULAR MEDICINE

Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways

(2019) Abolfazl Shakeri et al.   PHARMACOLOGICAL RESEARCH

Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy

(2019) Xianfeng Qu et al.   Experimental and Therapeutic Medicine

A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway

(2019) Yahui Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases

(2019) Lorena Perrone et al.   Nutrients

Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and Concerns

(2019) Zuqing Su et al.   Frontiers in Pharmacology

Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways

(2019) Yung-Chia Chen et al.   Journal of Clinical Medicine

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

(2019) Franco et al.   Antioxidants

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

(2019) Chiara Nediani et al.   Antioxidants

Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity

(2018) Tianru Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

(2018) Amin Ardestani et al.   Cell Metabolism

Alpha-synuclein, Proteotoxicity and Parkinson's Disease: Search for Neuroprotective Therapy

(2018) Upasana Ganguly et al.   Current Neuropharmacology

Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway

(2018) Xinhong Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

(2018) Daniel Peña-Oyarzun et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition

(2018) Pamela Nardiello et al.   JOURNAL OF ALZHEIMERS DISEASE

Beneficial Effects of Flavonoids Against Parkinson's Disease

(2018) Un Ju Jung et al.   JOURNAL OF MEDICINAL FOOD

Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones

(2018) Antonella Lascala et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients

(2018) Sokhna M. S. Yakhine-Diop et al.   MOLECULAR NEUROBIOLOGY

Dendritic Tau in Alzheimer’s Disease

(2018) Arne Ittner et al.   NEURON

Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

(2018) Joaquín G. Cordero et al.   Oxidative Medicine and Cellular Longevity

Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB

(2018) Caterina Miceli et al.   Oxidative Medicine and Cellular Longevity

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

(2018) Miriam García Hernández et al.   Cell Death & Disease

Involvement of autophagy in the beneficial effects of resveratrol in hepatic steatosis treatment. A comparison with energy restriction

(2018) I. Milton-Laskibar et al.   Food & Function

Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

(2018) Ankit Tandon et al.   Biomed Research International

Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy

(2018) Zhihao Wu et al.   EXPERIMENTAL GERONTOLOGY

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

(2018) Elena Radi et al.   JOURNAL OF ALZHEIMERS DISEASE

Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway

(2018) Yuexia Liao et al.   Journal of Immunology Research

Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis

(2018) Qing Yao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

(2018) Yi Huang et al.   Oxidative Medicine and Cellular Longevity

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

(2018) Alexa Serino et al.   Nutrients

mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

(2018) Carlos Guillén et al.   Frontiers in Endocrinology

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

(2017) Alberto Bartolomé et al.   MOLECULAR AND CELLULAR BIOLOGY

Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal

(2017) Ya-Fang Wang et al.   Molecular Medicine Reports

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes

(2017) Xuecong Ren et al.   Oxidative Medicine and Cellular Longevity

Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells

(2017) Hong Yao et al.   BioScience Trends

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

(2017) Seyed Fazel Nabavi et al.   BIOTECHNOLOGY ADVANCES

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

(2017) Shibin Ding et al.   PLoS One

Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy

(2017) Shibin Ding et al.   PLoS One

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy

(2016) Ana García-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

(2016) Miao Lou et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo

(2016) Kai-Chih Hung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

(2016) Lucio G. Costa et al.   Oxidative Medicine and Cellular Longevity

Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat

(2016) Liqun Ma et al.   PATHOLOGY RESEARCH AND PRACTICE

Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity

(2016) Narendra Nath Jha et al.   Scientific Reports

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection

(2015) Elzbieta Janda et al.   Autophagy

The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson’s Disease Model

(2015) Rosalba Siracusa et al.   CNS & Neurological Disorders-Drug Targets

Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo

(2015) Martial Kamdem Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

(2015) Ryoichi Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome

(2015) Maddalena Parafati et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

(2015) Yong Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

(2015) Mika Reinisalo et al.   Oxidative Medicine and Cellular Longevity

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

(2015) Suneng Fu et al.   Science Translational Medicine

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Lysosomal storage diseases as disorders of autophagy

(2014) Carmine Settembre et al.   Autophagy

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

(–)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto–Kakizaki rats

(2014) J. Liu et al.   FREE RADICAL RESEARCH

Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice

(2014) Bo Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quercetin alleviates high glucose-induced Schwann cell damage by autophagy

(2014) Ling Qu et al.   Neural Regeneration Research

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease

(2013) Lake Li et al.   FOOD AND CHEMICAL TOXICOLOGY

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

(2013) E Konings et al.   INTERNATIONAL JOURNAL OF OBESITY

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Autophagy, polyphenols and healthy ageing

(2012) Kathrin Pallauf et al.   AGEING RESEARCH REVIEWS

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

(2012) Alberto Bartolome et al.   Autophagy

Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins

(2012) Federico Pietrocola et al.   CELL CYCLE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate

(2012) Jiong Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

(2012) Elzbieta Janda et al.   MOLECULAR NEUROBIOLOGY

Reaction Dynamics of Flavonoids and Carotenoids as Antioxidants

(2012) Rui-Min Han et al.   MOLECULES

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Curcumin Alleviates Diabetic Cardiomyopathy in Experimental Diabetic Rats

(2012) Wei Yu et al.   PLoS One

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Stress hypERactivation in the β-cell

(2010) Sonya G. Fonseca et al.   Islets

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Endoplasmic reticulum stress in β-cells and development of diabetes

(2009) Sonya G Fonseca et al.   CURRENT OPINION IN PHARMACOLOGY

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Inhibition of transcriptional activity of c-JUN by SIRT1

(2008) Zhanguo Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE