Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

(2019) Chowdhury S. Abdullah et al.   Scientific Reports

Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

(2019) Michael P. Catanzaro et al.   FASEB JOURNAL

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

(2019) Nadine Wenningmann et al.   MOLECULAR PHARMACOLOGY

Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

(2019) Xiaoping Wang et al.   Cancers

SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function

(2019) Panxia Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II

(2018) Bo Wei et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based cellular migration

(2018) Hao Zhou et al.   CELLULAR SIGNALLING

Flavonoids as protective agents against oxidative stress induced by gentamicin in systemic circulation. Potent protective activity and microbial synergism of luteolin

(2018) Pamela Soledad Bustos et al.   FOOD AND CHEMICAL TOXICOLOGY

Luteolin activates ERK1/2- and Ca2+-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and mitigates acute lung injury of endotoxin mice

(2018) Eun Jung Park et al.   INFLAMMATION RESEARCH

Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy

(2018) Shuyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity

(2018) Rui Guo et al.   Cell Death & Disease

Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling

(2018) Zhidan Chen et al.   Theranostics

BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F-actin pathways

(2018) Hao Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy

(2017) Yan Xia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Autophagic dysregulation in doxorubicin cardiomyopathy

(2017) Jordan J. Bartlett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells

(2017) Hong Yao et al.   BioScience Trends

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

(2017) Navid Koleini et al.   Oncotarget

Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

(2016) J. J. Bartlett et al.   BIOCHEMICAL JOURNAL

Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism

(2016) Wei Ge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

Protection of Luteolin-7-O-Glucoside Against Doxorubicin-Induced Injury Through PTEN/Akt and ERK Pathway in H9c2 Cells

(2015) Hong Yao et al.   Cardiovascular Toxicology

Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats

(2015) Lie-Chwen Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Luteolin alleviates post-infarction cardiac dysfunction by up-regulating autophagy through Mst1 inhibition

(2015) Jianqiang Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy

(2014) Aijun Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy

(2013) Yingmei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ERK/PP1a/PLB/SERCA2a and JNK Pathways Are Involved in Luteolin-Mediated Protection of Rat Hearts and Cardiomyocytes following Ischemia/Reperfusion

(2013) Xin Wu et al.   PLoS One

Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity

(2012) Balindiwe J.N. Sishi et al.   BIOCHEMICAL PHARMACOLOGY

Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes

(2012) Tomonori Kawaguchi et al.   CARDIOVASCULAR RESEARCH

Effects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes

(2012) Polychronis Dimitrakis et al.   CELL AND TISSUE RESEARCH

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signaling pathway

(2012) Dongxu He et al.   FEBS Journal

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Doxorubicin-induced cardiac dysfunction is attenuated by ciclosporin treatment in mice through improvements in mitochondrial bioenergetics

(2011) Xavier Marechal et al.   CLINICAL SCIENCE

Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: Involvement of cell line-specific apoptotic mechanisms

(2011) Prema S. Rao et al.   INTERNATIONAL JOURNAL OF CANCER

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells

(2010) Shu-Qi Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women

(2009) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure

(2008) Lihe Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY