Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deceptive curcumin offers cautionary tale for chemists

(2017) Monya Baker   NATURE

Don't discount all curcumin trial data

(2017) Michal Heger   NATURE

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2

(2017) Lili Tian et al.   Cell Death & Disease

Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

(2017) Qian Chen et al.   Nutrients

Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

(2017) Mao Ye et al.   Frontiers in Pharmacology

Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance

(2016) Lulu Wang et al.   JOURNAL OF LIPID RESEARCH

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats

(2016) Nachimuthu Maithilikarpagaselvi et al.   PHARMACEUTICAL BIOLOGY

The chemistry of gut microbial metabolism of polyphenols

(2016) Jan F. Stevens et al.   PHYTOCHEMISTRY REVIEWS

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

(2016) Rohith N. Thota et al.   Trials

Unusual sub-genus associations of faecal Prevotella and Bacteroides with specific dietary patterns

(2016) Francesca De Filippis et al.   Microbiome

Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

(2015) Shan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

(2015) Clémence D Côté et al.   NATURE MEDICINE

Towards a more comprehensive concept for prebiotics

(2015) Laure B. Bindels et al.   Nature Reviews Gastroenterology & Hepatology

The update of anthocyanins on obesity and type 2 diabetes: Experimental evidence and clinical perspectives

(2015) Honghui Guo et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

(2014) Michael Rouse et al.   JOURNAL OF ENDOCRINOLOGY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR−/− Mice – Role of Intestinal Permeability and Macrophage Activation

(2014) Siddhartha S. Ghosh et al.   PLoS One

Salicylate (Salsalate) in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Stable and Potent Analogues Derived from the Modification of the Dicarbonyl Moiety of Curcumin

(2013) Soumyananda Chakraborti et al.   BIOCHEMISTRY

Gut microbiota, enteroendocrine functions and metabolism

(2013) Patrice D Cani et al.   CURRENT OPINION IN PHARMACOLOGY

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

(2013) Yu Li et al.   GASTROENTEROLOGY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle

(2012) Michael J. Boden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals

(2012) J. A. Rothwell et al.   Database-The Journal of Biological Databases and Curation

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress

(2011) L. E. Wright et al.   DIABETOLOGIA

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

(2011) Nathalie M. Delzenne et al.   Nature Reviews Endocrinology

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review

(2010) Jara Pérez-Jiménez et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Childhood obesity

(2010) Joan C Han et al.   LANCET

Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects

(2010) Jennie Wickenberg et al.   Nutrition Journal

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

(2009) Marie A. Hildebrandt et al.   GASTROENTEROLOGY

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY