Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment

(2019) Qian Yu et al.   Cell Death & Disease

Luteolin Ameliorates Testis Injury and Blood‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43

(2019) Bo Ma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

(2019) Magdy Selim et al.   LANCET NEUROLOGY

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial

(2019) Daniel F Hanley et al.   LANCET

Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

(2019) Eunok Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

(2019) Kyoung Ah Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

(2018) Louise Hecker   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes

(2018) Bobo Yang et al.   ARCHIVES OF TOXICOLOGY

Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity

(2018) Shun-Chin Yang et al.   BIOCHEMICAL PHARMACOLOGY

Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice

(2018) Yinping Du et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Strategies to Reduce Oxidative Stress in Glaucoma Patients

(2018) Maria D. Pinazo-Duran et al.   Current Neuropharmacology

Protective effects of dietary luteolin against mercuric chloride-induced lung injury in mice: Involvement of AKT/Nrf2 and NF-κB pathways

(2018) Biying Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349

(2018) Xiaohui Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary luteolin protects against HgCl 2 -induced renal injury via activation of Nrf2-mediated signaling in rat

(2018) Xiao Tan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats

(2018) Haiying Li et al.   NEUROBIOLOGY OF DISEASE

Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage

(2018) Lei Gong et al.   NEUROPHARMACOLOGY

Autophagy in hemorrhagic stroke: Mechanisms and clinical implications

(2018) Haiying Li et al.   PROGRESS IN NEUROBIOLOGY

Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes

(2018) Luc Rochette et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TAR DNA Binding Protein-43 Loss of Function Induced by Phosphorylation at S409/410 Blocks Autophagic Flux and Participates in Secondary Brain Injury After Intracerebral Hemorrhage

(2018) Liang Sun et al.   Frontiers in Cellular Neuroscience

PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro

(2018) Chengjie Meng et al.   Frontiers in Neuroscience

Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin

(2018) Montserrat Rojo de la Vega et al.   Frontiers in Pharmacology

Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice

(2018) Lianhua Zhao et al.   Journal of Neuroinflammation

Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction

(2018) Xiang Li et al.   NEUROPHARMACOLOGY

Green Tea and Red Tea from Camellia sinensis Partially Prevented the Motor Deficits and Striatal Oxidative Damage Induced by Hemorrhagic Stroke in Rats

(2018) Priscila Marques Sosa et al.   NEURAL PLASTICITY

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke

(2018) Chuanhong Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacodynamic Effect of Luteolin Micelles on Alleviating Cerebral Ischemia Reperfusion Injury

(2018) Liwei Tan et al.   Pharmaceutics

Association of oxidative stress with clinical characteristics in patients with rheumatoid arthritis

(2017) Sinan Kardeş et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Haematoma scavenging in intracerebral haemorrhage: from mechanisms to the clinic

(2017) Gaiqing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury

(2017) Jun-peng Pei et al.   Journal of Neuroinflammation

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

(2017) Jun-Xia Zhang et al.   MOLECULES

Oxidative Stress in Retinal Diseases

(2017) Yuhei Nishimura et al.   Oxidative Medicine and Cellular Longevity

Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells by luteolin through Nrf2 signaling

(2017) Young-Ok Son et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury

(2017) Wenzhe Xu et al.   Oncotarget

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

(2017) Chun-Chun Wei et al.   Scientific Reports

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury

(2017) Zhong Wang et al.   Translational Stroke Research

Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants

(2017) Asis Bala et al.   INFLAMMOPHARMACOLOGY

Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo

(2017) Yuanmin He et al.   Scientific Reports

Metabolic control and oxidative stress in pathological cardiac remodelling

(2016) Gabriele G. Schiattarella et al.   EUROPEAN HEART JOURNAL

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

(2016) Jie Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism

(2016) X Zhang et al.   INTERNATIONAL JOURNAL OF OBESITY

(−)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways

(2016) Xi Lan et al.   MOLECULAR NEUROBIOLOGY

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

(2015) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Ageing, inflammation, and oxidative stress: final common pathways of cardiovascular disease

(2015) Thomas F. Lüscher   EUROPEAN HEART JOURNAL

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Luteolin alleviates post-infarction cardiac dysfunction by up-regulating autophagy through Mst1 inhibition

(2015) Jianqiang Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in Rats

(2015) Haitao Shen et al.   STROKE

Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man

(2015) Carlo Caltagirone et al.   Translational Stroke Research

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

(2014) Jianguo Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

(2014) Xiurong Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

(2013) Emanuele D’Amico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia

(2012) Huimin Qiao et al.   BRAIN RESEARCH

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET