Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients

Acetylome in Human Fibroblasts From Parkinson's Disease Patients

(2018) Sokhna M. S. Yakhine-Diop et al.   Frontiers in Cellular Neuroscience

Genetics of Parkinson's disease

(2016) Christina M. Lill   MOLECULAR AND CELLULAR PROBES

A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease

(2016) Chi-Jing Choong et al.   NEUROBIOLOGY OF AGING

SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model

(2016) Jing-Yi Zhang et al.   NEUROCHEMICAL RESEARCH

New method to assess mitophagy flux by flow cytometry

(2015) Marta Mauro-Lizcano et al.   Autophagy

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease

(2015) Lei Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy

(2015) Yu-Chin Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?

(2015) Rosa Gonzalez-Polo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

(2014) Shu-Hui Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

G2019S LRRK2 mutant fibroblasts from Parkinson’s disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy

(2014) Sokhna M.S. Yakhine-Diop et al.   TOXICOLOGY

Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway

(2014) Xue Wei et al.   TOXICOLOGY MECHANISMS AND METHODS

Dimeric structure of p300/CBP associated factor

(2014) Shasha Shi et al.   BMC STRUCTURAL BIOLOGY

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

(2013) Susan Costantini et al.   BMC EVOLUTIONARY BIOLOGY

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

(2013) Rubén Gómez-Sánchez et al.   NEUROBIOLOGY OF DISEASE

Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins

(2012) Federico Pietrocola et al.   CELL CYCLE

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo

(2012) Yongbo Zhao et al.   EXPERIMENTAL NEUROLOGY

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

(2012) Tatiana D. Papkovskaia et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defects in Mitochondrial Fission Protein Dynamin-Related Protein 1 Are Linked to Apoptotic Resistance and Autophagy in a Lung Cancer Model

(2012) Kelly Jean Thomas et al.   PLoS One

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

(2012) C. Yi et al.   SCIENCE

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

 -Synuclein Negatively Regulates Protein Kinase C  Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

(2011) H. Jin et al.   JOURNAL OF NEUROSCIENCE

6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

(2011) Alison I Bernstein et al.   Molecular Neurodegeneration

Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration

(2011) C. Song et al.   NEUROTOXICOLOGY

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis

(2010) Mireia Niso-Santano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

Environmental Neurotoxic Pesticide Increases Histone Acetylation to Promote Apoptosis in Dopaminergic Neuronal Cells: Relevance to Epigenetic Mechanisms of Neurodegeneration

(2010) C. Song et al.   MOLECULAR PHARMACOLOGY

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA