Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
Authors
Keywords
Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), Nuclear factor erythroid 2-related factor 2 (Nrf2), Oxidative stress, Reactive oxygen species (ROS)
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 17, Pages 3221-3247
Publisher
Springer Nature
Online
2016-04-21
DOI
10.1007/s00018-016-2223-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
- (2016) Stefan W. Ryter et al. Translational Research
- A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity
- (2015) Monika Oláhová et al. AGING CELL
- Coupling mitogenesis and mitophagy for longevity
- (2015) Konstantinos Palikaras et al. Autophagy
- Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila
- (2015) Bing Wang et al. Biochemistry and Cell Biology
- Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress
- (2015) Hui-Teng Cheng et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy
- (2015) Madhusudhanan Narasimhan et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
- (2015) Niki Chondrogianni et al. FASEB JOURNAL
- Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinases
- (2015) Magdalena Tertil et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mechanisms and functions of Nrf2 signaling in Drosophila
- (2015) Andrew Pitoniak et al. FREE RADICAL BIOLOGY AND MEDICINE
- Structural basis of Keap1 interactions with Nrf2
- (2015) Peter Canning et al. FREE RADICAL BIOLOGY AND MEDICINE
- Heme oxygenase-1 modulates microRNA expression in cultured astroglia: Implications for chronic brain disorders
- (2015) Shih-Hsiung Lin et al. GLIA
- Effect of heme oxygenase-1 gene promoter polymorphism on cancer risk by histological subtype: A prospective study in arseniasis-endemic areas in Taiwan
- (2015) Meei-Maan Wu et al. INTERNATIONAL JOURNAL OF CANCER
- Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
- (2015) Ken Itoh et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Long-term safety and effectiveness of high-dose dimethylfumarate in the treatment of moderate to severe psoriasis: a prospective single-blinded follow-up study
- (2015) Raphaël Lijnen et al. JOURNAL OF DERMATOLOGICAL TREATMENT
- Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
- (2015) Konstantinos Palikaras et al. NATURE
- Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy
- (2015) Gururaj Joshi et al. NEUROBIOLOGY OF AGING
- Role of the Keap1/Nrf2 pathway in neurodegenerative diseases
- (2015) Hiromi Yamazaki et al. PATHOLOGY INTERNATIONAL
- HO-1/CO system in tumor growth, angiogenesis and metabolism — Targeting HO-1 as an anti-tumor therapy
- (2015) Agnieszka Loboda et al. VASCULAR PHARMACOLOGY
- Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway
- (2015) Rheinallt M. Jones et al. Cell Reports
- Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
- (2015) Michael J Steinbaugh et al. eLife
- Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview
- (2015) Roberto Bomprezzi Therapeutic Advances in Neurological Disorders
- Neurotherapeutic effects of novel HO-1 inhibitorsin vitroand in a transgenic mouse model of Alzheimer's disease
- (2015) Ajay Gupta et al. JOURNAL OF NEUROCHEMISTRY
- Sodium iodate induced retinal degeneration: new insights from an old model
- (2015) DavidR Hinton et al. Neural Regeneration Research
- mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity
- (2014) Masaki Mizunuma et al. AGING CELL
- Association Between Heme Oxygenase 1 Gene Promoter Polymorphisms and Susceptibility to Coronary Artery Disease: A HuGE Review and Meta-Analysis
- (2014) Huaiyu Qiao et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Association Between the (GT)n Polymorphism of the HO-1 Gene Promoter Region and Cancer Risk: a Meta-analysis
- (2014) Ling Zhang et al. Asian Pacific Journal of Cancer Prevention
- MicroRNAs Mediate Dietary-Restriction-Induced Longevity through PHA-4/FOXA and SKN-1/Nrf Transcription Factors
- (2014) Thalyana Smith-Vikos et al. CURRENT BIOLOGY
- Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation
- (2014) H. Deng et al. DEVELOPMENT
- Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
- (2014) Lei Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
- (2014) Shun Kageyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
- (2014) Collin Y. Ewald et al. NATURE
- Five-Year Incidence, Progression, and Risk Factors for Age-Related Macular Degeneration
- (2014) Fridbert Jonasson et al. OPHTHALMOLOGY
- Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aβ Toxicity
- (2014) Virve Kärkkäinen et al. STEM CELLS
- SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
- (2014) Shanshan Pang et al. Nature Communications
- Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
- (2013) Eleni N. Tsakiri et al. AGING CELL
- Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes
- (2013) Mohammed Mahidur Rahman et al. AGING CELL
- Interplay Between Heme Oxygenase-1 and miR-378 Affects Non-Small Cell Lung Carcinoma Growth, Vascularization, and Metastasis
- (2013) Klaudia Skrzypek et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
- (2013) Agnieszka Loboda et al. Biomolecules & Therapeutics
- The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways
- (2013) Pallavi Banerjee et al. CANCER LETTERS
- Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy
- (2013) Sankaranarayanan Kannan et al. CARDIOVASCULAR RESEARCH
- Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
- (2013) Alexander J. Gill et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Nrf2 signaling is impaired in the aging RPE given an oxidative insult
- (2013) Mira M. Sachdeva et al. EXPERIMENTAL EYE RESEARCH
- Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
- (2013) Eleni N. Tsakiri et al. FASEB JOURNAL
- Multiple roles of Nrf2-Keap1 signaling
- (2013) Huai Deng FLY
- Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila
- (2013) Jyoti R. Misra et al. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
- (2013) Anju Singh et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- The Involvement ofNRF2in Lung Cancer
- (2013) Alison K. Bauer et al. Oxidative Medicine and Cellular Longevity
- Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio
- (2013) Larissa M. Williams et al. PLoS One
- Retinal iron homeostasis in health and disease
- (2013) Delu Song et al. Frontiers in Aging Neuroscience
- Regulation of Drosophila Metamorphosis by Xenobiotic Response Regulators
- (2013) Huai Deng et al. PLoS Genetics
- Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster
- (2013) Péter Nagy et al. PLoS Genetics
- Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf
- (2013) Kira M. Glover-Cutter et al. PLoS Genetics
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
- (2013) Emilia Kansanen et al. Redox Biology
- TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
- (2012) Stacey Robida-Stubbs et al. Cell Metabolism
- Heme Oxygenase-1 in Tumor Biology and Therapy
- (2012) Halina Was et al. CURRENT DRUG TARGETS
- A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
- (2012) A. M. Pickering et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases
- (2012) Kunikazu Tanji et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
- (2012) B. N. Chorley et al. NUCLEIC ACIDS RESEARCH
- The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism
- (2012) Yoichiro Mitsuishi et al. Frontiers in Oncology
- Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism
- (2011) Agnieszka Jazwa et al. ANTIOXIDANTS & REDOX SIGNALING
- Heme Oxygenase-1 Inhibits Myoblast Differentiation by Targeting Myomirs
- (2011) Magdalena Kozakowska et al. ANTIOXIDANTS & REDOX SIGNALING
- The cytoprotective role of the Keap1–Nrf2 pathway
- (2011) Liam Baird et al. ARCHIVES OF TOXICOLOGY
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- (2011) Ralf A. Linker et al. BRAIN
- MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
- (2011) Muhua Yang et al. BREAST CANCER RESEARCH AND TREATMENT
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
- (2011) Christine E. Hochmuth et al. Cell Stem Cell
- Modification of Keap1 Cysteine Residues by Sulforaphane
- (2011) Chenqi Hu et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Second order regulator Collier directly controls intercalary-specific segment polarity gene expression
- (2011) Evgenia Ntini et al. DEVELOPMENTAL BIOLOGY
- Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease
- (2011) M. C. Barone et al. Disease Models & Mechanisms
- Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice
- (2011) Halina Was et al. FREE RADICAL BIOLOGY AND MEDICINE
- Transcriptional regulation of xenobiotic detoxification in Drosophila
- (2011) J. R. Misra et al. GENES & DEVELOPMENT
- miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recurrence and survival in pancreatic cancer
- (2011) Yogesh K. Vashist et al. JOURNAL OF SURGICAL ONCOLOGY
- An association between polymorphism of the heme oxygenase-1 and -2 genes and age-related macular degeneration
- (2011) Ewelina Synowiec et al. MOLECULAR BIOLOGY REPORTS
- Age-Related Retinopathy in NRF2-Deficient Mice
- (2011) Zhenyang Zhao et al. PLoS One
- Exacerbation of Oxidative Stress-Induced Cell Death and Differentiation in Induced Pluripotent Stem Cells Lacking Heme Oxygenase-1
- (2011) Chen-Yu Lin et al. STEM CELLS AND DEVELOPMENT
- The Nrf2-ARE Pathway
- (2010) Jeffrey A. Johnson et al. Annals of the New York Academy of Sciences
- Mechanisms of Cell Protection by Heme Oxygenase-1
- (2010) Raffaella Gozzelino et al. Annual Review of Pharmacology and Toxicology
- Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice
- (2010) Namakkal Soorappan Rajasekaran et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of Heme Oxygenase-1 in Human Endothelial Cells
- (2010) Hevidar Taha et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
- (2010) C. Sangokoya et al. BLOOD
- MicroRNAs Both Promote and Antagonize Longevity in C. elegans
- (2010) Alexandre de Lencastre et al. CURRENT BIOLOGY
- Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27
- (2010) Xia Zhang et al. HYPERTENSION
- Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity
- (2010) K. N. Lewis et al. INTEGRATIVE AND COMPARATIVE BIOLOGY
- C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements
- (2010) Smadar Levy et al. IUBMB LIFE
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism
- (2010) K. Trinh et al. JOURNAL OF NEUROSCIENCE
- Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia
- (2010) Nita Radhakrishnan et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome
- (2010) K. B. Grimberg et al. MOLECULAR AND CELLULAR BIOLOGY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
- (2010) Constance L. Saw et al. MOLECULAR CARCINOGENESIS
- Genetic and Cellular Characterization of Caenorhabditis elegans Mutants Abnormal in the Regulation of Many Phase II Enzymes
- (2010) Koichi Hasegawa et al. PLoS One
- Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1
- (2010) Nadia G. Innamorato et al. PLoS One
- Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
- (2010) G. P. Sykiotis et al. Science Signaling
- RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition
- (2010) Jinling Wang et al. PLoS Genetics
- Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration
- (2009) Kurt M. Bertram et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells
- (2009) Agnieszka Loboda et al. ANTIOXIDANTS & REDOX SIGNALING
- The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development
- (2009) G. Broitman-Maduro et al. DEVELOPMENT
- Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3β) on the risk of Parkinson’s disease
- (2009) J. Infante et al. EUROPEAN JOURNAL OF NEUROLOGY
- Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice
- (2009) Weisong Duan et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- The 26 S Proteasome: From Basic Mechanisms to Drug Targeting
- (2009) Ami Navon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic analysis of heme oxygenase-1 (HO-1) in German Parkinson’s disease patients
- (2009) Claudia Funke et al. JOURNAL OF NEURAL TRANSMISSION
- Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
- (2009) Yoo Ri Kim et al. JOURNAL OF PATHOLOGY
- The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans
- (2009) K. P. Choe et al. MOLECULAR AND CELLULAR BIOLOGY
- Effect of Heme Oxygenase-1 Deficiency on Placental Development
- (2009) H. Zhao et al. PLACENTA
- Targeting NRF2 signaling for cancer chemoprevention
- (2009) Mi-Kyoung Kwak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease
- (2008) Masaru Suzuki et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities
- (2008) Agnieszka Loboda et al. ANTIOXIDANTS & REDOX SIGNALING
- Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues
- (2008) Lihua Cui et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
- (2008) Jennifer M.A. Tullet et al. CELL
- ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult
- (2008) James D. McGhee et al. DEVELOPMENTAL BIOLOGY
- Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
- (2008) Gerasimos P. Sykiotis et al. DEVELOPMENTAL CELL
- Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease
- (2008) K. Trinh et al. JOURNAL OF NEUROSCIENCE
- Molecular mechanisms of Nrf2-mediated antioxidant response
- (2008) Wenge Li et al. MOLECULAR CARCINOGENESIS
- Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity
- (2008) S.-Y. Hung et al. MOLECULAR PHARMACOLOGY
- Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
- (2008) K. J. Pearson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?
- (2007) Volker Blank JOURNAL OF MOLECULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started