Article
Plant Sciences
Xinxin Liu, Ying Lv, Mengyu Zheng, Li Yin, Xiqing Wang, Yujie Fu, Bo Yu, Ji Li
Summary: The study found that blue honeysuckle berry extract inhibits lipid accumulation in adipocytes by activating AMPK and promoting the beiging of adipocytes, highlighting its potential as an anti-obesity agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yeon Ju Kim, Sung Yun Park, Ju-Hee Lee
Summary: The study revealed that berteroin significantly inhibits lipid synthesis and lipid droplet formation, potentially mediated by AMPK activation.
Article
Endocrinology & Metabolism
Wei Luo, Jiaxin Dai, Jianmin Liu, Yongmei Huang, Ziqiong Zheng, Pei Xu, Yi Ma
Summary: This study investigated the mechanism of PACAP in ameliorating metabolic disorder and its potential therapeutic effects on MAFLD. The results showed that PACAP reduced hepatic lipid accumulation and inhibited lipogenesis in HFD-fed mice. Mechanistically, PACAP activated the FAIM-AMPK-IR beta axis to inhibit lipid synthesis gene expression, and FAIM mediated the effects of PACAP. PACAP increased the promoter activity of FAIM gene through activating PKA-CREB signaling pathway.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen
Summary: Tanshinone IIA exhibits lipid-lowering effects by inhibiting genes related to lipogenesis, increasing phosphorylation of ACC1 protein, and regulating the expression of SREBP1, potentially through modulating the LXR alpha/SREBP1 pathway in hepatic cells.
Article
Medicine, Research & Experimental
Farah Gulzar, Shadab Ahmad, Sushmita Singh, Pawan Kumar, Aditya Sharma, Akhilesh K. Tamrakar
Summary: This study demonstrates that activation of NOD1 in adipocytes can affect lipid metabolism in hepatocytes by promoting lipolysis and inflammatory responses. This effect is associated with enhanced transport of fatty acids and increased triglyceride synthesis rate in hepatocytes. Additionally, NOD1 activation induces inflammatory response and impairs insulin signaling in hepatocytes.
Article
Chemistry, Medicinal
Jin Young Suh, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Nari Shin, Bonglee Kim, Bum Sang Shim, Sung-Hoon Kim
Summary: This study found that icariside E4 (IE4) has the potential to reduce lipid accumulation in HepG2 hepatocellular carcinoma cells (HCCs) by activating the AMPK signaling pathway and inhibiting the expression of MID1IP1. It may be a promising candidate for the treatment of fatty liver disease.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Olivia M. Tandrasasmita, Guntur Berlian, Raymond R. Tjandrawinata
Summary: The study showed that DLBS3733 can significantly reduce lipid accumulation and TG synthesis in HepG2 cells by increasing adiponectin expression, regulating PPAR alpha and AMPK signaling pathways, and inhibiting the expression of HMGCR, ACC, SREBP. Additionally, DLBS3733 exhibits high antioxidant activity, suggesting its potential as a treatment for hepatic steatosis-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shun Hasei, Takeshi Yamamotoya, Yusuke Nakatsu, Yukino Ohata, Shota Itoga, Yuji Nonaka, Yasuka Matsunaga, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Tomoichiro Asano
Summary: CA and CL have been shown to inhibit hepatic gluconeogenesis-related enzymes by activating AMPK, and reduce the expression levels of genes related to fatty acid synthesis. Additionally, CA and CL can suppress cell proliferation and reduce cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Youli Li, Min Gu, Xuanzhe Liu, Jianna Lin, Huier Jiang, Huiyun Song, Xingcui Xiao, Wei Zhou
Summary: This study sequenced and compared the mitochondrial genomes of Toona sinensis and Toona ciliata, and analyzed their repetitive sequences in comparison with the chloroplast genome. Phylogenetic analysis revealed the evolutionary relationship between these two species.
Article
Biochemistry & Molecular Biology
Ji Li, Xuedong Wang, Xiangyu Meng, Xin Zhou, Han Huang, Yi Feng, Yujie Fu, Xinxin Liu, Bo Yu
Summary: Obesity is a global burden linked to severe medical complications. Geraniin, a polyphenolic compound, has shown pharmacological effects in reducing lipid accumulation and obesity. This study investigates the mechanism of geraniin in inhibiting lipid accumulation in adipocytes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Weiqun Yang, Xiaoyun Zheng, Jingyan Bai, Pinfei Zhong, Shaoli Tan, Wei Zeng, Jie Chen, Zhanghua Sun, Zhongqiu Liu, Jing Jin, Zhongxiang Zhao
Summary: This study investigated the lipid-lowering effect, structure-activity relationship, and action mechanism of triterpenoids from the genus Ilex. Thirteen triterpenoids showed significant lipid-lowering effects, with rotundic acid (RA) exhibiting stronger activity than the positive control. The study revealed that RA regulated glycerophospholipid and sphingolipid metabolism and activated the AMPK pathway to achieve lipid-lowering effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Hyuk-Cheol Kwon, Do-Hyun Kim, Chang-Hee Jeong, Yea-Ji Kim, Jong-Hyun Han, Su-Jin Lim, Dong-Min Shin, Dong-Wook Kim, Sung-Gu Han
Summary: The study found that TEB can induce lipid accumulation by altering the expression of lipid-metabolizing molecules, affecting cellular lipid metabolism, increasing oxidative stress levels, and potentially leading to non-alcoholic fatty liver disease.
Article
Biochemistry & Molecular Biology
Shu Zeng, Min Tao, Lei Yuan, Lili Zhang, Xie Luo
Summary: mGluR5 plays a role in the development of NAFLD, with its antagonist reducing lipid accumulation and its agonist promoting lipid deposition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Si-wei Wang, Tian Lan, Hang-fei Chen, Hao Sheng, Chun-yi Xu, Li-feng Xu, Fang Zheng, Feng Zhang
Summary: This study reported the inhibitory effect of limonin on hepatic lipid accumulation and fatty acid synthesis in HFD fed mice, and found that this effect was dependent on the activation of AMPK. The activation of AMPK by limonin was achieved by inhibiting cellular energy metabolism and increasing the ADP:ATP ratio, leading to the suppression of the transcriptional activity of SREBP1/2. These findings suggest that limonin may be a promising therapeutic agent for the treatment of NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Young-Hyun Lee, Hwa-Jin Kim, Mikyoung You, Hyeon-A Kim
Summary: This study investigated the inhibitory effect of red pepper seed extract (RPS) on hepatic lipid accumulation. The results showed that RPS treatment suppressed lipogenesis and induced hepatic autophagy, leading to a reduction in lipid accumulation. This effect was mediated through the AMPK-dependent pathway. In vitro experiments also demonstrated the ability of RPS to decrease lipid accumulation and downregulate lipogenesis-associated proteins in an oleic acid-induced hepatic steatosis cell model.
Article
Biotechnology & Applied Microbiology
Fu-Chi Kang, Pei-Jung Chen, Bo-Syong Pan, Meng-Shao Lai, Yung-Chia Chen, Bu-Miin Huang
ONCOTARGETS AND THERAPY
(2015)
Article
Food Science & Technology
Yung-Chia Chen, Yi-Lin Liang, Yuan-Li Huang, Bu-Miin Huang
JOURNAL OF FUNCTIONAL FOODS
(2015)
Article
Oncology
Yung-Chia Chen, Ling-Hui Chien, Bu-Miin Huang, Yi-Chen Chia, Hui-Fen Chiu
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2016)
Article
Biotechnology & Applied Microbiology
Edmund Cheung So, Yung-Chia Chen, Shu-Chun Wang, Chia-Ching Wu, Man-Chi Huang, Meng-Shao Lai, Bo-Syong Pan, Fu-Chi Kang, Bu-Miin Huang
ONCOTARGETS AND THERAPY
(2016)
Article
Biochemistry & Molecular Biology
Meng-Shao Lai, Chia-Yih Wang, Shang-Hsun Yang, Chia-Ching Wu, H. Sunny Sun, Shaw-Jenq Tsai, Jih-Ing Chuang, Yung-Chia Chen, Bu-Miin Huang
Review
Food Science & Technology
Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang
JOURNAL OF FOOD AND DRUG ANALYSIS
(2017)
Article
Plant Sciences
Cheng Liu, Wei-Chang Lee, Bu-Miin Huang, Yi-Chen Chia, Yu-Chi Chen, Yung-Chia Chen
Article
Medicine, Research & Experimental
Chih-Jen Yang, Yung-Chia Chen, Yee-Jean Tsai, Ming-Shyan Huang, Chao-Chuan Wang
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2014)
Article
Biotechnology & Applied Microbiology
Yu-Chi Chen, Bu-Miin Huang, Wei-Chang Lee, Yung-Chia Chen
ONCOTARGETS AND THERAPY
(2018)
Article
Biochemistry & Molecular Biology
Yu-Chi Chen, Po-Yu Wang, Bu-Miin Huang, Yu-Jen Chen, Wei-Chang Lee, Yung-Chia Chen
Review
Biochemistry & Molecular Biology
Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang, Rong-Jane Chen
Summary: Cordycepin, derived from Cordyceps sinensis, is a herbal medicine with potential anti-cancer properties through regulating multiple signaling pathways and inducing autophagy. It has been suggested as an alternative treatment due to its involvement in autophagic signaling and its effects on cell death, tumor metastasis inhibition, and immune system modulation.
Review
Biochemistry & Molecular Biology
Yung-Chia Chen, Yi-Chen Chia, Bu-Miin Huang
Summary: Polyalthia, belonging to the Annonaceae family, are evergreen trees distributed in tropical and subtropical regions, with medicinal properties. Recent studies have shown that compounds from Polyalthia exhibit antioxidant, antimicrobial, antitumor, and anticancer activities, providing potential for cancer chemoprevention.
Article
Toxicology
Yu-Chi Chen, Chih- Chen, Chao-Yuan Chang, Bu-Miin Huang, Yung-Chia Chen
Summary: This study found that 16-hydroxycleroda-3,13-dien-15,16-olide (CD) inhibits the growth, migration, and invasion of bladder cancer cells by blocking intracellular signaling pathways and affecting histone deacetylase (HDAC) activity.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
J. Guo, X. Zhou, Y. Chen, M. Bai, X. Yang, K. Zhao, W. Hao, W. Wei, Y. Zhang
CELLULAR AND MOLECULAR BIOLOGY
(2014)