Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels

(2014) Franciele Donato et al.   BRAIN RESEARCH BULLETIN

Gelidium elegans, an Edible Red Seaweed, and Hesperidin Inhibit Lipid Accumulation and Production of Reactive Oxygen Species and Reactive Nitrogen Species in 3T3-L1 and RAW264.7 Cells

(2014) Hui-Jeon Jeon et al.   PHYTOTHERAPY RESEARCH

Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage

(2013) Bidya Dhar Sahu et al.   PHYTOMEDICINE

Hesperidin Prevents Androgen Deficiency-induced Bone Loss in Male Mice

(2013) Hiroshige Chiba et al.   PHYTOTHERAPY RESEARCH

Novel Insights into the Pharmacology of Flavonoids

(2013) Barbara Romano et al.   PHYTOTHERAPY RESEARCH

Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3′-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities

(2013) Masaki Yamamoto et al.   Food & Function

Citrus flavonoids and lipid metabolism

(2012) Julia M. Assini et al.   CURRENT OPINION IN LIPIDOLOGY

7,3′-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis

(2012) Rong Li et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Therapeutic effect of 7, 3′-dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway

(2012) Rong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperidin attenuates brain biochemical changes of irradiated rats

(2012) Ussama Z. Said et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Protective Effect of Hesperidin, a Citrus Flavanoglycone, Against γ-Radiation-Induced Tissue Damage in Sprague–Dawley Rats

(2012) Kannampalli Pradeep et al.   JOURNAL OF MEDICINAL FOOD

Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart

(2012) Jayasudha Elavarasan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats

(2012) Xiupu Shi et al.   MOLECULES

Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation

(2012) Daxin Li et al.   PHARMACEUTICAL BIOLOGY

Pharmacokinetics of Hesperetin and Naringenin in the Zhi Zhu Wan, a Traditional Chinese Medicinal Formulae, and its Pharmacodynamics Study

(2012) Hui Sun et al.   PHYTOTHERAPY RESEARCH

Effects of Flavonoids and other Polyphenols on Inflammation

(2011) R. González et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways

(2011) Sang Rim Kang et al.   FOOD CHEMISTRY

Hesperidin Suppresses Ovalbumin-Induced Airway Inflammation in a Mouse Allergic Asthma Model

(2011) Dajun Wei et al.   INFLAMMATION

Antioxidant and Anti-Inflammatory Potential of Hesperetin Metabolites Obtained from Hesperetin-Administered Rat Serum: An Ex Vivo Approach

(2011) Hsin-Ling Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma

(2011) Seung-Hyung Kim et al.   MEDIATORS OF INFLAMMATION

Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation

(2011) Shiekh Tanveer Ahmad et al.   TOXICOLOGY LETTERS

Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9

(2010) Sattu Kamaraj et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes

(2010) Mingcang Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice

(2010) Sattu Kamaraj et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation

(2010) Mandipika Jain et al.   INFLAMMATION RESEARCH

Hesperidin Upregulates Heme Oxygenase-1 To Attenuate Hydrogen Peroxide-Induced Cell Damage in Hepatic L02 Cells

(2010) Ming-cang Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata

(2010) Katarzyna Kazłowska et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of Antioxidant and Inhibitory Activities for Different Subclasses Flavonoids on Enzymes for Rheumatoid Arthritis

(2010) Je-Hyuk Lee et al.   JOURNAL OF FOOD SCIENCE

Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel

(2009) Yung-Sheng Huang et al.   FOOD CHEMISTRY

Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cells

(2009) Seyed Jalal Hosseinimehr et al.   NUCLEAR MEDICINE AND BIOLOGY

Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

(2009) M. Cecilia Martínez et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium

(2009) Lei Xu et al.   PHYTOMEDICINE

Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity

(2009) Rong Li et al.   PHYTOTHERAPY RESEARCH

Hesperidin attenuates benzo[α] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance

(2009) HMM Arafa et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Effects of α-Glucosylhesperidin, a Bioactive Food Material, on Collagen-Induced Arthritis in Mice and Rheumatoid Arthritis in Humans

(2008) Takashi Kometani et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells

(2008) Irina Tsoy Nizamutdinova et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain

(2008) El-Sayed M. El-Sayed et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms

(2008) Rong Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane

(2008) K. B. Kalpana et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY