Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

α-Linolenic acid–derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40

(2018) Ryuji Ohue-Kitano et al.   FASEB JOURNAL

Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice

(2017) Hiroko Kaikiri et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice

(2017) Matthew J. Dalby et al.   Cell Reports

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages

(2017) Akira Nakajima et al.   PLoS One

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

(2016) Artemis Simopoulos   Nutrients

Microbial regulation of GLP-1 and L-cell biology

(2016) Thomas U. Greiner et al.   Molecular Metabolism

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

(2015) G Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of the linoleic acid Δ9 hydratase catalyzing the first step of polyunsaturated fatty acid saturation metabolism in Lactobacillus plantarum AKU 1009a

(2015) Michiki Takeuchi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes

(2015) Tharnath Nanthirudjanar et al.   LIPIDS

Intercellular Lipid Mediators and GPCR Drug Discovery

(2014) Dong-Soon Im   Biomolecules & Therapeutics

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

(2014) Junki Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Free fatty acid receptors as therapeutic targets for the treatment of diabetes

(2014) Atsuhiko Ichimura et al.   Frontiers in Pharmacology

Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon

(2013) Yumiko Iizuka et al.   Journal of Physiological Sciences

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

(2013) S. Kishino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus

(2013) Louise Kristine Vigsnaes et al.   Scientific Reports

Mediator lipidomics in acute inflammation and resolution

(2012) M. Arita   JOURNAL OF BIOCHEMISTRY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors

(2012) S. Tunaru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel multi-component enzyme machinery in lactic acid bacteria catalyzing CC double bond migration useful for conjugated fatty acid synthesis

(2011) Shigenobu Kishino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production

(2009) Shigenobu Kishino et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel selective ligands for free fatty acid receptors GPR120 and GPR40

(2009) Takafumi Hara et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of the dietary fat quality on insulin sensitivity

(2008) José E. Galgani et al.   BRITISH JOURNAL OF NUTRITION

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE