Clinical implications of understanding the association between oxidative stress and pediatric NAFLD

The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH)

(2016) Rohini Mehta et al.   BMC Medical Genetics

Reactive oxygen species and fibrosis: further evidence of a significant liaison

(2016) Kati Richter et al.   CELL AND TISSUE RESEARCH

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space

(2016) Phanee Manganas et al.   CELL AND TISSUE RESEARCH

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores

(2016) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease

(2016) Shikha S. Sundaram et al.   JOURNAL OF HEPATOLOGY

Nocturnal hypoxia in obese-related obstructive sleep apnea as a putative trigger of oxidative stress in pediatric NAFLD progression

(2016) Maurizio Parola et al.   JOURNAL OF HEPATOLOGY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Oxidative stress and lipotoxicity

(2016) Amy K. Hauck et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

Nonalcoholic fatty liver disease and obstructive sleep apnea

(2016) Judith Aron-Wisnewsky et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle

(2016) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet?

(2016) Naim Alkhouri et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genetics of nonalcoholic fatty liver disease

(2016) Paola Dongiovanni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view

(2016) Michael J. Pagliassotti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

(2016) Pierre Theurey et al.   Journal of Molecular Cell Biology

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

(2016) Tuulia Hyötyläinen et al.   Nature Communications

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

(2016) Torsten Schröder et al.   Molecular Metabolism

Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice

(2016) Han-Sol Park et al.   Diabetes & Metabolism Journal

Plasma Cathepsin D Levels: A Novel Tool to Predict Pediatric Hepatic Inflammation

(2015) Sofie M A Walenbergh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease

(2015) Nishanth E. Sunny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic NOS inhibition accelerates NAFLD progression in an obese rat model

(2015) Ryan D. Sheldon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

(2015) Magdalena Mazagova et al.   FASEB JOURNAL

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease

(2015) Johannie du Plessis et al.   GASTROENTEROLOGY

Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease

(2015) Rui Guo et al.   Hepatobiliary & Pancreatic Diseases International

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

(2015) You Zhou et al.   JOURNAL OF HEPATOLOGY

Redox signalling and mitochondrial stress responses; lessons from inborn errors of metabolism

(2015) Rikke K. J. Olsen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening

(2015) Xueyao Yin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Endoplasmic Reticulum Stress Response in Non-alcoholic Steatohepatitis: The Possible Role of Physical Exercise

(2015) Emanuel Passos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Cholesterol is a significant risk factor for non-alcoholic steatohepatitis

(2015) Sofie MA Walenbergh et al.   Expert Review of Gastroenterology & Hepatology

The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease

(2015) Alexandra Feldman et al.   Biomed Research International

MicroRNAs in Nonalcoholic Fatty Liver Disease

(2015) György Baffy   Journal of Clinical Medicine

The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis

(2014) Amit G Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

(2014) Yong-Hyun Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

OxNASH Score Correlates with Histologic Features and Severity of Nonalcoholic Fatty Liver Disease

(2014) Naim Alkhouri et al.   DIGESTIVE DISEASES AND SCIENCES

Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21

(2014) Hyunbae Kim et al.   ENDOCRINOLOGY

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments

(2014) Inês O. Gonçalves et al.   MITOCHONDRION

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

(2014) Hwan-Woo Park et al.   Nature Communications

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Oxidized Fatty Acids: A Potential Pathogenic Link Between Fatty Liver and Type 2 Diabetes in Obese Adolescents?

(2013) Nicola Santoro et al.   ANTIOXIDANTS & REDOX SIGNALING

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

(2013) Maja A. Fedorowicz et al.   EMBO REPORTS

mmu-miR-702 functions as an anti-apoptotic mirtron by mediating ATF6 inhibition in mice

(2013) Wei-guang Zhang et al.   GENE

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

The liver diseases of lipodystrophy: The long-term effect of leptin treatment

(2013) Elika Safar Zadeh et al.   JOURNAL OF HEPATOLOGY

Obstructive Sleep Apnea and Hypoxemia Are Associated with Advanced Liver Histology in Pediatric Nonalcoholic Fatty Liver Disease

(2013) Shikha S. Sundaram et al.   JOURNAL OF PEDIATRICS

Non-alcoholic fatty liver disease in obese children and the relationship between metabolic syndrome criteria

(2013) Mehmet Boyraz et al.   Obesity Research & Clinical Practice

Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways

(2013) Meng-Han Lin et al.   TOXICOLOGY

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

(2012) Anne Leroux et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

(2012) Sofie M.A. Walenbergh et al.   JOURNAL OF HEPATOLOGY

Levels of Serum Ceruloplasmin Associate With Pediatric Nonalcoholic Fatty Liver Disease

(2012) Valerio Nobili et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?

(2012) Carmine Finelli   WORLD JOURNAL OF GASTROENTEROLOGY

Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis

(2011) Srinivasan Dasarathy et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

High fructose feeding induces copper deficiency in Sprague–Dawley rats: A novel mechanism for obesity related fatty liver

(2011) Ming Song et al.   JOURNAL OF HEPATOLOGY

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

(2011) Ahmad Al-Serri et al.   JOURNAL OF HEPATOLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption

(2010) Jaimie N Davis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease

(2010) Elmar Aigner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Early interplay of intra-hepatic iron and insulin resistance in children with non-alcoholic fatty liver disease

(2010) Melania Manco et al.   JOURNAL OF HEPATOLOGY

Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice

(2010) Jamil A Haque et al.   LABORATORY INVESTIGATION

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients

(2010) Adeline Bertola et al.   PLoS One

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity

(2010) S. W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Control of Endoplasmic Reticulum Function

(2009) Miklós Csala et al.   ANTIOXIDANTS & REDOX SIGNALING

Caspases and Kinases in a Death Grip

(2009) Manabu Kurokawa et al.   CELL

Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease

(2009) Giuseppe Paradies et al.   CELL CALCIUM

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Luca Valenti et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study

(2009) Ariel E. Feldstein et al.   HEPATOLOGY

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

(2009) T Yamauchi et al.   INTERNATIONAL JOURNAL OF OBESITY

Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children

(2009) I Aeberli et al.   INTERNATIONAL JOURNAL OF OBESITY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Probiotics Reduce the Inflammatory Response Induced by a High-Fat Diet in the Liver of Young Rats

(2009) Emanuela Esposito et al.   JOURNAL OF NUTRITION

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury

(2008) G Serviddio et al.   GUT

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY