Mitochondrial Metabolism in the Intestinal Stem Cell Niche—Sensing and Signaling in Health and Disease

The olfactory G protein-coupled receptor (Olfr-78/OR51E2) modulates the intestinal response to colitis

(2020) Kumar Kotlo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation

(2020) Garret Vincent et al.   ANTIOXIDANTS & REDOX SIGNALING

LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate

(2020) Yajing Gao et al.   GASTROENTEROLOGY

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

(2020) Nick Powell et al.   GUT

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

(2020) Dakota N Jackson et al.   GUT

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence

(2020) Sevana Khaloian et al.   GUT

P011 Dysbiosis and Goblet cells depletion triggers early intestinal barrier dysfunction that precedes gut inflammation in IL-10 deficient mice (IL-10−/−)

(2020) B López Cauce et al.   Journal of Crohns & Colitis

Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation

(2020) Antonin Levy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

(2020) Vanessa Brinkmann et al.   Frontiers in Physiology

An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease

(2020) Jan Wehkamp et al.   Frontiers in Immunology

High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

(2020) Jee-Yon Lee et al.   Cell Host & Microbe

TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation

(2020) Fei Chen et al.   Cell Death & Disease

A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis

(2020) Ceren Ozkul et al.   Genome Medicine

The influence of mitochondrial-directed regulation of Wnt signaling on tumorigenesis

(2020) Yaritza Delgado-Deida et al.   Gastroenterology Report

IDO1+ Paneth cells promote immune escape of colorectal cancer

(2020) Sandra Pflügler et al.   Communications Biology

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

(2020) Pu-Hyeon Cha et al.   BRITISH JOURNAL OF CANCER

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

(2020) Amira Metwaly et al.   Nature Communications

The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer

(2019) Yang-An Wen et al.   CELL DEATH AND DIFFERENTIATION

Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

(2019) Ludovica Marinelli et al.   Scientific Reports

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation

(2019) Lauren V. Albrecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-22 protects intestinal stem cells against genotoxic stress

(2019) Konrad Gronke et al.   NATURE

DOP12 Mutations in the X-linked inhibitor of apoptosis protein promote susceptibility to microbiota-induced intestinal inflammation

(2019) S Gopalakrishnan et al.   Journal of Crohns & Colitis

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

Metabolic pathways regulating colorectal cancer initiation and progression

(2019) Sofia La Vecchia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer

(2019) Yeji Kim et al.   Scientific Reports

Macrophages as a Source and Recipient of Wnt Signals

(2019) Elizabeth S. Malsin et al.   Frontiers in Immunology

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

(2019) Roberto Costa et al.   Cell Reports

Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity

(2019) Jesús Cosin-Roger et al.   Frontiers in Immunology

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

(2019) Yi Wang et al.   CELL

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

(2019) Yu Chen et al.   PLOS BIOLOGY

Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers

(2019) Yves Lecarpentier et al.   Frontiers in Oncology

The Role of Immune Cells and Cytokines in Intestinal Wound Healing

(2019) Xiang Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

(2019) Irina A. Okkelman et al.   Redox Biology

Paneth Cell Multipotency Induced by Notch Activation following Injury

(2018) Shiyan Yu et al.   Cell Stem Cell

Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling

(2018) Dominic B. Bernkopf et al.   JOURNAL OF CELL BIOLOGY

Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease

(2018) Taekil Eom et al.   JOURNAL OF MICROBIOLOGY

Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

(2018) Eva Rath et al.   Nature Reviews Gastroenterology & Hepatology

Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors

(2018) Yang Yang et al.   Cell Death & Disease

Butyrate: A Double-Edged Sword for Health?

(2018) Hu Liu et al.   Advances in Nutrition

Cellular Interactions in the Intestinal Stem Cell Niche

(2018) Agnieszka Pastuła et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

(2018) Amina Metidji et al.   IMMUNITY

ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract

(2018) Akie Inami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation

(2018) Kathleen A. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

(2018) James R. Bayrer et al.   Nature Communications

Characterization of bacterial microbiota compositions along the intestinal tract in pigs and their interactions and functions

(2018) Daniel Crespo-Piazuelo et al.   Scientific Reports

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

(2018) Mark Schmitt et al.   Cell Reports

Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer

(2018) Maureen Spit et al.   Open Biology

Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development

(2018) Yong-Soo Lee et al.   Cell Host & Microbe

ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides

(2018) Xiaoming Hu et al.   GASTROENTEROLOGY

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis

(2018) Olivia I. Coleman et al.   GASTROENTEROLOGY

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

(2018) Yael Haberman et al.   Nature Communications

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche

(2018) Elle Koren et al.   Nature Communications

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis

(2017) Victoria Jeffery et al.   JOURNAL OF IMMUNOLOGY

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease

(2017) Emily M. Bradford et al.   JOURNAL OF IMMUNOLOGY

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

(2017) E Cuyàs et al.   ONCOGENE

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance

(2017) Tomoaki Naito et al.   mBio

Activation of intestinal olfactory receptor stimulates glucagon-like peptide-1 secretion in enteroendocrine cells and attenuates hyperglycemia in type 2 diabetic mice

(2017) Ki-Suk Kim et al.   Scientific Reports

The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism

(2017) Guang Shi et al.   Cell Reports

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells

(2016) J F van Lidth de Jeude et al.   ONCOGENE

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

(2016) Jung-ha Park et al.   PLoS One

Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome

(2016) Hye Jin Hwang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

(2016) Noortje Ijssennagger et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease

(2016) Walid Mottawea et al.   Nature Communications

The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration

(2016) Fanny L. Casado   Stem Cells International

Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1

(2016) Tamara Zietek et al.   Frontiers in Immunology

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

(2015) S. Das et al.   DEVELOPMENT

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

(2015) Patricia Aparicio-Domingo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells

(2015) Michael A. Kohanski et al.   International Forum of Allergy & Rhinology

Microbiota–mitochondria inter-talk: consequence for microbiota–host interaction

(2015) Yann Saint-Georges-Chaumet et al.   Pathogens and Disease

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics

(2014) Wendy S. Hahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

(2014) Julia Beisner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Standardised animal models of host microbial mutualism

(2014) A J Macpherson et al.   Mucosal Immunology

YY1 is indispensable for Lgr5+ intestinal stem cell renewal

(2014) A. O. Perekatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

(2014) Elena Bellafante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

(2013) S. Kalghatgi et al.   Science Translational Medicine

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Paneth Cells in Colonic Adenomas

(2012) Rish K. Pai et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Mitochondrial superoxide production contributes to vancomycin-induced renal tubular cell apoptosis

(2012) Yohei Arimura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

(2012) Matthew D. Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Paneth Cells in Intestinal Homeostasis and Tissue Injury

(2012) Sabrina Roth et al.   PLoS One

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

(2012) Dallas R. Donohoe et al.   PLoS One

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association Between the Use of Antibiotics and New Diagnoses of Crohn's Disease and Ulcerative Colitis

(2011) Souradet Y Shaw et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Mitochondria at the Interface Between Danger Signaling and Metabolism: Role of Unfolded Protein Responses in Chronic Inflammation

(2011) Eva Rath et al.   INFLAMMATORY BOWEL DISEASES

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death

(2011) P. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Association Between the Use of Antibiotics in the First Year of Life and Pediatric Inflammatory Bowel Disease

(2010) Souradet Y Shaw et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial stem cell-related alterations inTrichinella spiralis-infected small intestine

(2009) R. Walsh et al.   CELL PROLIFERATION

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Evolving paradigms in the pathogenesis of IBD

(2009) Lloyd Mayer   JOURNAL OF GASTROENTEROLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA