An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

(2020) Nick Powell et al.   GUT

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

(2020) Dakota N Jackson et al.   GUT

An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

(2020) Lishan Zeng et al.   Journal of Translational Medicine

Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis

(2020) Louis Koeninger et al.   Frontiers in Immunology

Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids

(2019) Yuki Yokoi et al.   Scientific Reports

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

(2019) D. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome

(2019) Ellen Li et al.   PLoS One

Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1

(2019) Shaonan Liang et al.   Cell Host & Microbe

Environmental Risk Factors for Inflammatory Bowel Diseases: an Umbrella Review of Meta-analyses

(2019) Daniele Piovani et al.   GASTROENTEROLOGY

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

Paneth cell dysfunction mediates alcoholic steatohepatitis through promoting bacterial translocation in mice: role of zinc deficiency

(2019) Wei Zhong et al.   HEPATOLOGY

Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice

(2019) Loni Berkowitz et al.   Frontiers in Immunology

Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells

(2019) Akiko Takakuwa et al.   Nutrients

Microbiota and mucosal defense in IBD: an update

(2019) Eduard F. Stange et al.   Expert Review of Gastroenterology & Hepatology

Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility

(2018) E. Cerrillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut Microbiota as a Modulator of Paneth Cells During Parenteral Nutrition in Mice

(2018) Jiwei Wang et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Paneth Cells during Viral Infection and Pathogenesis

(2018) Mayumi Holly et al.   Viruses-Basel

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

(2018) Konrad Aden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides

(2018) Xiaoming Hu et al.   GASTROENTEROLOGY

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease

(2018) Ta-Chiang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

(2018) Yael Haberman et al.   Mucosal Immunology

Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine

(2018) Pradeep K. Shukla et al.   Scientific Reports

Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

(2018) Tomoya Iida et al.   Cells

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity

(2017) Ambre Riba et al.   GASTROENTEROLOGY

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

(2017) Markus Tschurtschenthaler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

(2017) Eiko Hayase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells

(2017) Haifang Wang et al.   JOURNAL OF IMMUNOLOGY

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn’s Disease

(2016) Ryohei Hayashi et al.   INFLAMMATORY BOWEL DISEASES

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

(2016) Danmei Su et al.   Frontiers in Physiology

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Crohn's disease-derived monocytes fail to induce Paneth cell defensins

(2015) Lioba F. Courth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulation of Human Enteric Antimicrobial Peptides by NOD2 during Differentiation of the Paneth Cell Lineage

(2015) Gao Tan et al.   Scientific Reports

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

(2014) Julia Beisner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration

(2014) Markus Tschurtschenthaler et al.   GUT

Host Defense Peptide Resistance Contributes to Colonization and Maximal Intestinal Pathology by Crohn's Disease-Associated Adherent-Invasive Escherichia coli

(2014) Joseph B. McPhee et al.   INFECTION AND IMMUNITY

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A small intestinal organoid model of non-invasive enteric pathogen–epithelial cell interactions

(2014) S S Wilson et al.   Mucosal Immunology

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

(2014) B O Schroeder et al.   Mucosal Immunology

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Mouse Paneth cell antimicrobial function is independent of Nod2

(2013) Michael T Shanahan et al.   GUT

Human β-Defensin 3 Peptide Is Increased and Redistributed in Crohn’s Ileitis

(2013) Jeffrey P. Meisch et al.   INFLAMMATORY BOWEL DISEASES

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Intestinal Intraepithelial Lymphocyte-Enterocyte Crosstalk Regulates Production of Bactericidal Angiogenin 4 by Paneth Cells upon Microbial Challenge

(2013) Catherine R. Walker et al.   PLoS One

Dysbiosis—A consequence of Paneth cell dysfunction

(2013) Nita H. Salzman et al.   SEMINARS IN IMMUNOLOGY

Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn's Disease

(2012) Élodie Thachil et al.   GASTROENTEROLOGY

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

(2012) Megan Raetz et al.   NATURE IMMUNOLOGY

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

(2012) Maureen J. Koslowski et al.   PLoS Genetics

Crohn disease: A current perspective on genetics, autophagy and immunity

(2011) Thaddeus S. Stappenbeck et al.   Autophagy

The potter’s wheel: the host’s role in sculpting its microbiota

(2011) Charles L. Bevins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expansion of Paneth Cell Population in Response to Enteric Salmonella enterica Serovar Typhimurium Infection

(2011) Nadine R. Martinez Rodriguez et al.   INFECTION AND IMMUNITY

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals

(2011) Caroline M Hodin et al.   JOURNAL OF PATHOLOGY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

(2010) Lisa A Simms et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Intestinal alpha-defensin expression in pediatric inflammatory bowel disease1

(2010) M. Zilbauer et al.   INFLAMMATORY BOWEL DISEASES

Paneth's disease

(2010) Jan Wehkamp et al.   Journal of Crohns & Colitis

Bactericidal Activity of Mouse α-Defensin Cryptdin-4 Predominantly Affects Noncommensal Bacteria

(2010) Koji Masuda et al.   Journal of Innate Immunity

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Direct Bacterial Killing In Vitro by Recombinant Nod2 Is Compromised by Crohn's Disease-Associated Mutations

(2010) Laurent-Herve Perez et al.   PLoS One

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

(2010) A. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Paneth Cell—Mediated Host Defense in Pediatric Ileal Crohn's Disease

(2009) Gøri Perminow et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Colony Stimulating Factor-1 Dependence of Paneth Cell Development in the Mouse Small Intestine

(2009) Duy Huynh et al.   GASTROENTEROLOGY

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

(2009) Alex Gregorieff et al.   GASTROENTEROLOGY

Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohnʼs disease

(2009) Anna Negroni et al.   INFLAMMATORY BOWEL DISEASES

MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function

(2009) Jesus K. Yamamoto-Furusho et al.   INFLAMMATORY BOWEL DISEASES

α-Defensins in Enteric Innate Immunity

(2009) Jennifer R. Mastroianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease, Stress, and the Endoplasmic Reticulum

(2009) Hans Clevers   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

(2009) Maureen J. Koslowski et al.   PLoS One

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Luminal Processing of Human Defensin-5 in Crohn's Disease

(2008) David Elphick et al.   AMERICAN JOURNAL OF PATHOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT

IL-17 produced by Paneth cells drives TNF-induced shock

(2008) Nozomi Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine

(2007) T Fishbein et al.   GUT