The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes

(2019) Kai Mao et al.   Cell Metabolism

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

(2019) Georges E. Janssens et al.   Cell Reports

Lack of the aryl hydrocarbon receptor accelerates aging in mice

(2019) Isabel Bravo-Ferrer et al.   FASEB JOURNAL

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids

(2018) Un-Ho Jin et al.   TOXICOLOGICAL SCIENCES

AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation

(2018) Carrie Hayes Sutter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis

(2017) Durgesh Nandini Das et al.   FREE RADICAL BIOLOGY AND MEDICINE

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome

(2017) Serena Dato et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

(2017) Marjan Ajami et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Indoles from commensal bacteria extend healthspan

(2017) Robert Sonowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung regeneration after toxic injury is improved in absence of dioxin receptor

(2017) Antonio Morales-Hernández et al.   Stem Cell Research

Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

(2017) Zhaohui Xue et al.   Food & Function

Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis

(2017) Nuria Moreno-Marín et al.   Scientific Reports

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome

(2016) Hye Jin Hwang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The aryl hydrocarbon receptor promotes aging phenotypes across species

(2016) Anna Eckers et al.   Scientific Reports

Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster

(2016) Ekaterina Proshkina et al.   Frontiers in Pharmacology

Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio)

(2015) Dongxu Gao et al.   AQUATIC TOXICOLOGY

Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ

(2015) Anna Smirnova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of p53 in Human and Murine Cells by DNA-Damaging Agents Differentially Regulates Aryl Hydrocarbon Receptor Levels

(2015) Ravichandran Panchanathan et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge

(2015) Mei Ming et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes

(2015) Vinicius S. Carreira et al.   TOXICOLOGICAL SCIENCES

Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions

(2015) Qin Wang et al.   TOXICOLOGICAL SCIENCES

The Biology of Aging

(2015) M. Kaeberlein   VETERINARY PATHOLOGY

AhR expression and polymorphisms are associated with risk of coronary arterial disease in Chinese population

(2015) Shian Huang et al.   Scientific Reports

Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult

(2015) Vinicius S. Carreira et al.   PLoS One

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

(2014) Cristian Sandoval-Acuña et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The interplay between mitochondria and autophagy and its role in the aging process

(2014) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis

(2014) Silvia Maglioni et al.   EXPERIMENTAL GERONTOLOGY

Aryl Hydrocarbon Receptor Mediates Indoxyl Sulfate-Induced Cellular Senescence in Human Umbilical Vein Endothelial Cells

(2014) Masayuki Koizumi et al.   Journal of Atherosclerosis and Thrombosis

The hallmarks of fibroblast ageing

(2014) Julia Tigges et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement

(2014) Evan G. Williams et al.   PLoS Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Sensory Neuron Fates Are Distinguished by a Transcriptional Switch that Regulates Dendrite Branch Stabilization

(2013) Cody J. Smith et al.   NEURON

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

(2013) P. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice

(2013) Kameshwar P. Singh et al.   STEM CELLS AND DEVELOPMENT

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

(2012) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

(2012) Ina Caesar et al.   PLoS One

Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice

(2012) R. Butler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inherent and Benzo[a]pyrene-Induced Differential Aryl Hydrocarbon Receptor Signaling Greatly Affects Life Span, Atherosclerosis, Cardiac Gene Expression, and Body and Heart Growth in Mice

(2012) Joanna S. Kerley-Hamilton et al.   TOXICOLOGICAL SCIENCES

Activation of Aryl Hydrocarbon Receptor Induces Vascular Inflammation and Promotes Atherosclerosis in Apolipoprotein E−/− Mice

(2011) Dalei Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis

(2011) Angela Rico de Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function

(2011) Dorothy M. Tappenden et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dioxins and Human Toxicity

(2010) Natalija Marinković et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

An introduction to the molecular basics of aryl hydrocarbon receptor biology

(2010) Josef Abel et al.   BIOLOGICAL CHEMISTRY

Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans

(2010) Vuokko Aarnio et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Transcriptional Factor Aryl Hydrocarbon Receptor (Ahr) Controls Cardiovascular and Respiratory Functions by Regulating the Expression of theVav3Proto-oncogene

(2010) Vincent Sauzeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Characterization of the region of the aryl hydrocarbon receptor required for ligand dependency of transactivation using chimeric receptor between Drosophila and Mus musculus

(2009) Kyoko Kudo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

The immune phenotype of AhR null mouse mutants: Not a simple mirror of xenobiotic receptor over-activation

(2008) Charlotte Esser   BIOCHEMICAL PHARMACOLOGY

Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43

(2008) Kerstin Pietsch et al.   BIOGERONTOLOGY

An update on the dietary ligands of the AhR

(2008) Hitoshi Ashida et al.   Expert Opinion on Drug Metabolism & Toxicology

Disruption of Aryl Hydrocarbon Receptor (AhR) Induces Regression of the Seminal Vesicle in Aged Male Mice

(2008) T. Baba et al.   Sexual Development

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

(2007) Andreas Kampkötter et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY