Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

The metabolic programming of stem cells

(2017) Ng Shyh-Chang et al.   GENES & DEVELOPMENT

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

Clonal evolution of colorectal cancer in IBD

(2017) Chang-Ho R. Choi et al.   Nature Reviews Gastroenterology & Hepatology

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

(2017) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Stem Cells in Repair of Gastrointestinal Epithelia

(2017) Amanda Andersson-Rolf et al.   PHYSIOLOGY

Signalling in the gut endocrine axis

(2017) Fiona M Gribble et al.   PHYSIOLOGY & BEHAVIOR

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation

(2017) Andrea C. Lei-Leston et al.   Frontiers in Immunology

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

On the linkage between the ubiquitin-proteasome system and the mitochondria

(2016) Gilad Lehmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer

(2016) Francesca Rappa et al.   CELL STRESS & CHAPERONES

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis

(2016) Namit Kumar et al.   DEVELOPMENT

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

(2016) Hiroyuki Miyoshi et al.   EMBO JOURNAL

The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis

(2016) Masayoshi Kato et al.   EXPERIMENTAL ANIMALS

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

(2016) Leesa L. Sampson et al.   FASEB JOURNAL

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Metabolism and the UPR mt

(2016) Yi-Fan Lin et al.   MOLECULAR CELL

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

(2016) Navdeep S. Chandel et al.   NATURE CELL BIOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome

(2016) Hye Jin Hwang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions

(2016) Chenxia He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The tumor promoting roles of HSP60 and HIF2α in gastric cancer cells

(2016) Wei-Wei Tong et al.   TUMOR BIOLOGY

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

(2016) Wakana Ohashi et al.   PLoS Genetics

Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1

(2016) Tamara Zietek et al.   Frontiers in Immunology

Microbial regulation of GLP-1 and L-cell biology

(2016) Thomas U. Greiner et al.   Molecular Metabolism

The Quest for Targets Executing MYC-Dependent Cell Transformation

(2016) Markus Hartl   Frontiers in Oncology

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent

(2015) Ankur Datta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adenomatous polyposis coli (APC)-induced apoptosis of HT29 colorectal cancer cells depends on mitochondrial oxidative metabolism

(2015) Maricarmen Cristofaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thiol switches in mitochondria: operation and physiological relevance

(2015) Jan Riemer et al.   BIOLOGICAL CHEMISTRY

CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma

(2015) Daniela Cabibi et al.   CELL STRESS & CHAPERONES

HSP60 overexpression increases the protein levels of the p110α subunit of  phosphoinositide 3-kinase and c-Myc

(2015) Feng-Qin Yan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression

(2015) P. Charitou et al.   EMBO REPORTS

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function

(2015) In-Sung Song et al.   GASTROENTEROLOGY

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

(2015) Eric C. Cheung et al.   GENES & DEVELOPMENT

Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?

(2015) Thierry Arnould et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

(2015) Jason C. Mills et al.   Science Signaling

Epithelial stem cells and intestinal cancer

(2015) Shawna Tan et al.   SEMINARS IN CANCER BIOLOGY

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

(2015) Jason C. Mills et al.   Science Signaling

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis

(2014) Peiwei Li et al.   GUT

Ex vivo culture of the intestinal epithelium: strategies and applications

(2014) Marc Leushacke et al.   GUT

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection

(2014) Susana Fuentes et al.   ISME Journal

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation

(2014) N Waldschmitt et al.   Mucosal Immunology

Standardised animal models of host microbial mutualism

(2014) A J Macpherson et al.   Mucosal Immunology

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

(2014) Tae-Hee Kim et al.   NATURE

PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

(2014) Elena Bellafante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial pathology: stress signals from the energy factory

(2014) Nuno Raimundo   TRENDS IN MOLECULAR MEDICINE

Epithelial Cell Shedding and Barrier Function

(2014) J. M. Williams et al.   VETERINARY PATHOLOGY

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design

(2013) Andrea Pace et al.   CURRENT PHARMACEUTICAL DESIGN

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Keeping mitochondria in shape: a matter of life and death

(2013) Luca Scorrano   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Inflammatory Tissue Microenvironment in IBD

(2013) Sean P. Colgan et al.   INFLAMMATORY BOWEL DISEASES

The sirtuin family’s role in aging and age-associated pathologies

(2013) Jessica A. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Innate immune recognition of the microbiota promotes host-microbial symbiosis

(2013) Hiutung Chu et al.   NATURE IMMUNOLOGY

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia

(2013) Rebeca Santaolalla et al.   PLoS One

Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

(2013) A. Kasahara et al.   SCIENCE

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Diet, Microbiome, and the Intestinal Epithelium: An Essential Triumvirate?

(2013) Javier Rivera Guzman et al.   Biomed Research International

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels

(2012) Michael S. Lustgarten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

(2012) Jin Zhang et al.   Cell Stem Cell

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

(2012) Nick Barker et al.   Cell Stem Cell

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications

(2012) R. M. Jones et al.   CURRENT MEDICINAL CHEMISTRY

Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

(2012) Matthew D. Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

(2012) S. M. Blattler et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

(2012) Dallas R. Donohoe et al.   PLoS One

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

Mitochondrial oxidative stress and the metabolic syndrome

(2012) Andrew M. James et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH

(2012) Chiara Stringari et al.   Scientific Reports

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells

(2011) Rebecca J. Boohaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells

(2011) Ilenia D’Errico et al.   CELL CYCLE

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

(2011) Jennifer R. Hom et al.   DEVELOPMENTAL CELL

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

(2011) Jin Zhang et al.   EMBO JOURNAL

Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies

(2011) Eva Rath et al.   EUROPEAN JOURNAL OF NUTRITION

Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis

(2011) Louise E. Glover et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

(2011) Eva Rath et al.   GUT

Mitochondria at the Interface Between Danger Signaling and Metabolism: Role of Unfolded Protein Responses in Chronic Inflammation

(2011) Eva Rath et al.   INFLAMMATORY BOWEL DISEASES

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Phenotyping of the Crohn's Disease-like IBD Etiopathology in the TNFΔARE/WTMouse Model

(2011) Pia Baur et al.   JOURNAL OF PROTEOME RESEARCH

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

(2011) William T. Senapedis et al.   MOLECULAR BIOLOGY OF THE CELL

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

Wnt signalling and the control of cellular metabolism

(2010) Jaswinder K. Sethi et al.   BIOCHEMICAL JOURNAL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

(2010) Naomi Haga et al.   CANCER SCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Metabolic Regulation of Stem Cell Behavior and Implications for Aging

(2010) Heinrich Jasper et al.   Cell Metabolism

Targeting Wnt Signaling in Colon Cancer Stem Cells

(2010) E. M. F. de Sousa et al.   CLINICAL CANCER RESEARCH

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

Erratum: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2010) Lenny Dang et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Immunohistochemical Expression of Hsp60 Correlates With Tumor Progression and Hormone Resistance in Prostate Cancer

(2010) Carolina Castilla et al.   UROLOGY

The Role of NF-κB in Hypoxia-Induced Gene Expression

(2009) Cormac T. Taylor et al.   Annals of the New York Academy of Sciences

Interaction between HSP60 and β-catenin promotes metastasis

(2009) Ya-Ping Tsai et al.   CARCINOGENESIS

The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling

(2009) Jieru Egeria Lin et al.   GASTROENTEROLOGY

Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases

(2009) X Yu et al.   GENES AND IMMUNITY

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohnʼs disease

(2009) Belén Beltrán et al.   INFLAMMATORY BOWEL DISEASES

Gene Expression Profiling Identifies a Role for CHOP During Inhibition of the Mitochondrial Respiratory Chain

(2009) F. Ishikawa et al.   JOURNAL OF BIOCHEMISTRY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

(2009) N Raimundo et al.   ONCOGENE

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Expression of Heat Shock Protein 60 kDa Is Upregulated in Cervical Cancer

(2009) You Jin Hwang et al.   YONSEI MEDICAL JOURNAL

Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

(2008) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Cancer stem cells – old concepts, new insights

(2008) L Vermeulen et al.   CELL DEATH AND DIFFERENTIATION

Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance

(2008) J LIM et al.   CELLULAR SIGNALLING

Identification of tumor antigens that elicit a humoral immune response in breast cancer patients' sera by serological proteome analysis (SERPA)

(2008) Bechr Hamrita et al.   CLINICA CHIMICA ACTA

Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

(2008) Mandana Amiri et al.   Developmental Neurobiology

Direct regulation ofHSP60expression by c-MYC induces transformation

(2008) Ya-Ping Tsai et al.   FEBS LETTERS

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOX enzymes and Toll-like receptor signaling

(2008) Eric Ogier-Denis et al.   Seminars in Immunopathology

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

(2007) Claire Pecqueur et al.   FASEB JOURNAL

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY