Butyrate: A Double-Edged Sword for Health?

Microbiota-Gut-Brain Axis: Modulator of Host Metabolism and Appetite

(2017) Marcel van de Wouw et al.   JOURNAL OF NUTRITION

Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB

(2017) Robert E. Steinert et al.   PHYSIOLOGICAL REVIEWS

Editorial: Impacts and Regulation of Dietary Nutrients on Gut Microbiome and Immunity

(2017) Long He et al.   PROTEIN AND PEPTIDE LETTERS

Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

(2017) Kiran V. Sandhu et al.   Translational Research

Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine

(2016) Julian Trachsel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

(2016) Laurent Counillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

TLR ligands and butyrate increasePyyexpression through two distinct but inter-regulated pathways

(2016) Pierre Larraufie et al.   CELLULAR MICROBIOLOGY

The Signal Pathway of Antibiotic Alternatives on Intestinal Microbiota and Immune Function

(2016) Ji Wang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials

(2016) Ralph A. DeFronzo et al.   DIABETOLOGIA

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

(2016) Roman M. Stilling et al.   NEUROCHEMISTRY INTERNATIONAL

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice

(2016) Jian Hong et al.   Oncotarget

Building a Beneficial Microbiome from Birth

(2016) Esther Castanys-Muñoz et al.   Advances in Nutrition

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Effects of Sodium Butyrate Treatment on Histone Modifications and the Expression of Genes Related to Epigenetic Regulatory Mechanisms and Immune Response in European Sea Bass (Dicentrarchus Labrax) Fed a Plant-Based Diet

(2016) Genciana Terova et al.   PLoS One

Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells

(2015) Anoop Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transfer of energy pathway genes in microbial enhanced biological phosphorus removal communities

(2015) Dennis H.-J. Wong et al.   BMC GENOMICS

The Rebirth of Culture in Microbiology through the Example of Culturomics To Study Human Gut Microbiota

(2015) Jean-Christophe Lagier et al.   CLINICAL MICROBIOLOGY REVIEWS

Editorial (Thematic Issue: Advance of Interactions Between Exogenous Natural Bioactive Peptides and Intestinal Barrier and Immune Responses)

(2015) Wenhui Wang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis

(2015) Jingshu Chen et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut

(2015) Peixin Fan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

The role of short chain fatty acids in appetite regulation and energy homeostasis

(2015) C S Byrne et al.   INTERNATIONAL JOURNAL OF OBESITY

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

(2015) Shou-Peng Fu et al.   Journal of Neuroinflammation

Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets

(2015) Chang Huang et al.   JOURNAL OF NUTRITION

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone

(2015) Yuanyuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Role of Resistant Starch in Improving Gut Health, Adiposity, and Insulin Resistance

(2015) Michael J Keenan et al.   Advances in Nutrition

Microbial Degradation of Whole-Grain Complex Carbohydrates and Impact on Short-Chain Fatty Acids and Health

(2015) Knud Erik Bach Knudsen   Advances in Nutrition

Butyrate and propionate improve the growth performance ofLitopenaeus vannamei

(2014) Bruno Corrêa da Silva et al.   AQUACULTURE RESEARCH

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Biological significance of short-chain fatty acid metabolism by the intestinal microbiome

(2014) Elena Puertollano et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

(2014) Hui Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of p38 Mitogen-Activated Protein Kinase Attenuates Butyrate-Induced Intestinal Barrier Impairment in a Caco-2 Cell Monolayer Model

(2014) Xiao-Zhong Huang et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Butyrate Increases Intracellular Calcium Levels and Enhances Growth Hormone Release from Rat Anterior Pituitary Cells via the G-Protein-Coupled Receptors GPR41 and 43

(2014) Maria Consolata Miletta et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impacts of Plant-Based Foods in Ancestral Hominin Diets on the Metabolism and Function of Gut Microbiota In Vitro

(2014) G. S. Frost et al.   mBio

Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data

(2014) M. Vital et al.   mBio

The Impact of Diet and Lifestyle on Gut Microbiota and Human Health

(2014) Michael Conlon et al.   Nutrients

Dietary Whole Grain–Microbiota Interactions: Insights into Mechanisms for Human Health

(2014) Nancy L. Keim et al.   Advances in Nutrition

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Translating Molecular Physiology of Intestinal Transport Into Pharmacologic Treatment of Diarrhea: Stimulation of Na+ Absorption

(2013) Varsha Singh et al.   Clinical Gastroenterology and Hepatology

Butyrate and Colorectal Cancer: The Role of Butyrate Transport

(2013) Pedro Gonçalves et al.   CURRENT DRUG METABOLISM

Glucagon-like peptide-1: modulator ofβ-cell dysfunction and death

(2013) D. Rondas et al.   DIABETES OBESITY & METABOLISM

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions1

(2013) X. Ma et al.   JOURNAL OF ANIMAL SCIENCE

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome

(2013) Cheri L. Deal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Diet High in Resistant Starch Modulates Microbiota Composition, SCFA Concentrations, and Gene Expression in Pig Intestine

(2013) Daniëlle Haenen et al.   JOURNAL OF NUTRITION

Short-Chain Fatty Acids Activate AMP-Activated Protein Kinase and Ameliorate Ethanol-Induced Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers

(2013) Elhaseen E. Elamin et al.   JOURNAL OF NUTRITION

High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response

(2013) Humberto Gagliano et al.   NEUROPHARMACOLOGY

Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

(2013) L. K. Brahe et al.   Obesity Reviews

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Fiber and Prebiotics: Mechanisms and Health Benefits

(2013) Joanne Slavin   Nutrients

Resistant Starch: Promise for Improving Human Health

(2013) Diane F. Birt et al.   Advances in Nutrition

The role of gut microbiota in the gut-brain axis: current challenges and perspectives

(2013) Xiao Chen et al.   Protein & Cell

Effect of Intestinal Microbial Ecology on the Developing Brain

(2013) Martha Douglas-Escobar et al.   JAMA Pediatrics

Butyrate

(2012) Alda J. Leonel et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

(2012) Hong-Bo Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Gut microbiota and gastrointestinal health: current concepts and future directions

(2012) Q. Aziz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery

(2012) Ilaria Russo et al.   PLoS One

Dietary Fiber

(2012) Nancy D. Turner et al.   Advances in Nutrition

Nutritional Factors Influencing Intestinal Health of the Neonate

(2012) Sheila K. Jacobi et al.   Advances in Nutrition

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

(2012) Roberto Berni Canani et al.   Clinical Epigenetics

The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease

(2011) Sarah A. Ingersoll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Novel Antiinflammatory Role for the Short-Chain Fatty Acids in Human Labor

(2011) Chiara Voltolini et al.   ENDOCRINOLOGY

Fermentation in the Human Large Intestine

(2011) George T. Macfarlane et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin, and on rumen papilla development in calves

(2011) Shin-Ichi Kato et al.   JOURNAL OF ENDOCRINOLOGY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nicotinic Acid Receptor Abnormalities in Human Skin Cancer: Implications for a Role in Epidermal Differentiation

(2011) Yira Bermudez et al.   PLoS One

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

(2011) Roberto Berni Canani   WORLD JOURNAL OF GASTROENTEROLOGY

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

(2010) Kees Meijer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats

(2010) Rodolphe Soret et al.   GASTROENTEROLOGY

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

From the gut to the peripheral tissues: the multiple effects of butyrate

(2010) P. Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?

(2010) M. Diamant et al.   Obesity Reviews

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites

(2009) Marco A. R. Vinolo et al.   CLINICAL SCIENCE

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Butyrate modulates oxidative stress in the colonic mucosa of healthy humans

(2008) Henrike M. Hamer et al.   CLINICAL NUTRITION