Journal
GASTROENTEROLOGY REPORT
Volume 8, Issue 3, Pages 215-223Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gastro/goaa025
Keywords
beta beta-catenin; cancer stem cells; metabolic reprogramming; metabolism; PGAM5
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Funding
- National Institutes of Health [R01-DK117001]
- Litwin IBD Pioneers Crohn's Colitis Foundation [391869]
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Mitochondria are dynamic organelles that play a key role in integrating cellular signaling. Mitochondrial alterations are evident in all stages of tumorigenesis and targeting mitochondrial pathways has emerged as an anticancer therapeutic strategy. The Wnt-signaling pathway regulates many fundamental cellular functions such as proliferation, survival, migration, stem-cell maintenance, and mitochondrial metabolismand dynamics. Emerging evidence demonstrates that mitochondrial-induced regulation of Wnt signaling provides an additional mechanism to influence cell-fate decisions. Crosstalk between mitochondria and Wnt signaling presents a feedforward loop in which Wnt activation regulates mitochondrial function that, in turn, drives Wnt signaling. In this mini-review, we will discuss the recent evidence revealing the mitochondrial control of Wnt signaling and its implications for tumorigenesis and anticancer therapeutic targeting.
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