Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

(2014) S. C. Gribar et al.   JOURNAL OF IMMUNOLOGY

Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium

(2012) A. Afrazi et al.   JOURNAL OF IMMUNOLOGY

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

(2012) M. Good et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

(2012) T.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DrosophilaRas/MAPK signalling regulates innate immune responses in immune and intestinal stem cells

(2011) Anan Ragab et al.   EMBO JOURNAL

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

(2011) Arnout G Schepers et al.   EMBO JOURNAL

p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

(2011) Ramanarao Dirisina et al.   GASTROENTEROLOGY

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Regulation of the Potential Marker for Intestinal Cells, Bmi1, by β-Catenin and the Zinc Finger Protein KLF4

(2011) Tianxin Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis

(2011) Chun-Liang Chen et al.   LABORATORY INVESTIGATION

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Necrotizing Enterocolitis

(2011) Josef Neu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expansion of Intestinal Epithelial Stem Cells during Murine Development

(2011) Jeffrey J. Dehmer et al.   PLoS One

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis

(2010) Ludmila Khailova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium

(2010) Ward M. Richardson et al.   GASTROENTEROLOGY

Intestinal Stem Cells and Their Roles During Mucosal Injury and Repair

(2010) Matthew D. Neal et al.   JOURNAL OF SURGICAL RESEARCH

EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture

(2010) Atsushi Suzuki et al.   LABORATORY INVESTIGATION

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

(2010) Cristina Aguilera et al.   NATURE

New Insights Into the Pathogenesis and Treatment of Necrotizing Enterocolitis: Toll-Like Receptors and Beyond

(2010) Amin Afrazi et al.   PEDIATRIC RESEARCH

Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice

(2009) Christopher M. Dekaney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PUMA Suppresses Intestinal Tumorigenesis in Mice

(2009) W. Qiu et al.   CANCER RESEARCH

Drosophila Intestinal Response to Bacterial Infection: Activation of Host Defense and Stem Cell Proliferation

(2009) Nicolas Buchon et al.   Cell Host & Microbe

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

(2009) Rocio Sancho et al.   EMBO JOURNAL

Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

(2009) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Intestinal Stem Cells

(2009) Aaron P Garrison et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

(2008) Wei Qiu et al.   Cell Stem Cell

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS