Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

(2018) Mami Morita et al.   CANCER CELL

Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices

(2018) Ahmed A. Almousa et al.   CLINICAL BIOCHEMISTRY

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

(2018) Qian Xiao et al.   NATURE MEDICINE

The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose

(2018) Xiang Li et al.   Cell Death & Disease

Current and upcoming mitochondrial targets for cancer therapy

(2017) Hyoung Kyu Kim et al.   SEMINARS IN CANCER BIOLOGY

PKM1 is involved in resistance to anti-cancer drugs

(2016) Kohei Taniguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function

(2015) In-Sung Song et al.   GASTROENTEROLOGY

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

(2015) JUN HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

(2015) Corti Denise et al.   Oncotarget

Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms

(2015) Kohei Taniguchi et al.   Scientific Reports

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

(2015) Cheng Zhan et al.   PLoS One

PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells

(2014) Haili Wu et al.   CELLULAR SIGNALLING

Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling

(2014) Peng Yang et al.   CELLULAR SIGNALLING

In vivo imaging of Lgr5-positive cell populations using confocal laser endomicroscopy during early colon tumorigenesis

(2014) Jin Choi et al.   ENDOSCOPY

Transcriptional Analysis of Left-sided Colitis, Pancolitis, and Ulcerative Colitis-associated Dysplasia

(2014) Jacob T. Bjerrum et al.   INFLAMMATORY BOWEL DISEASES

LGR5 positivity defines stem-like cells in colorectal cancer

(2013) Daniela Hirsch et al.   CARCINOGENESIS

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling

(2013) Trinidad Montero-Meléndez et al.   PLoS One

Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer

(2012) G. Rao et al.   CLINICAL CANCER RESEARCH

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

(2012) M. Cortes-Cros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Single-cell dissection of transcriptional heterogeneity in human colon tumors

(2011) Piero Dalerba et al.   NATURE BIOTECHNOLOGY

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

DICKKOPF-4and-2genes are upregulated in human colorectal cancer

(2009) Akira Matsui et al.   CANCER SCIENCE

Osteopontin induces β-catenin signaling through activation of Akt in prostate cancer cells

(2009) Brian W. Robertson et al.   EXPERIMENTAL CELL RESEARCH

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

(2009) I. Arijs et al.   GUT

Fecal dimeric M2-pyruvate kinase (tumor M2-PK) in the differential diagnosis of functional and organic bowel disorders

(2009) Jinny Jeffery et al.   INFLAMMATORY BOWEL DISEASES

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY