FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
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Title
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
Authors
Keywords
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Journal
Frontiers in Endocrinology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-12-14
DOI
10.3389/fendo.2020.601290
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- (2014) Lisa M. Glass et al. DIGESTIVE DISEASES AND SCIENCES
- Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
- (2014) Ffolliott M. Fisher et al. GASTROENTEROLOGY
- Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice
- (2014) Dewei Ye et al. HEPATOLOGY
- Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity
- (2014) Cynthia D. Guy et al. HEPATOLOGY
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- (2014) J M Gallego-Escuredo et al. INTERNATIONAL JOURNAL OF OBESITY
- Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis
- (2014) Shan Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FGF21 is an endocrine signal of protein restriction
- (2014) Thomas Laeger et al. JOURNAL OF CLINICAL INVESTIGATION
- CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
- (2014) Xiang Zhang et al. JOURNAL OF HEPATOLOGY
- Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
- (2014) Manoja K. Brahma et al. JOURNAL OF LIPID RESEARCH
- NLRP3 inflammasome activation is required for fibrosis development in NAFLD
- (2014) Alexander Wree et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- FGF21 inhibits apolipoprotein(a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway
- (2014) Xiaolong Lin et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- A nontumorigenic variant of FGF19 treats cholestatic liver diseases
- (2014) J. Luo et al. Science Translational Medicine
- Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
- (2014) Á González-Rodríguez et al. Cell Death & Disease
- Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity
- (2014) Alexandra Kukat et al. PLoS Genetics
- New avenues for regulation of lipid metabolism by thyroid hormones and analogs
- (2014) Rosalba Senese et al. Frontiers in Physiology
- Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
- (2014) Johanna Mäkelä et al. SpringerPlus
- Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors
- (2013) Wing Sun Chow et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
- (2013) Zhuofeng Lin et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
- (2013) L. Valenti et al. DIABETES
- Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
- (2013) K. M. Habegger et al. DIABETES
- Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
- (2013) João Paulo G. Camporez et al. ENDOCRINOLOGY
- Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
- (2013) Jennifer E. Lambert et al. GASTROENTEROLOGY
- Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
- (2013) Jean-Philippe Pradere et al. HEPATOLOGY
- NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
- (2013) Alexander Wree et al. HEPATOLOGY
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- (2013) Daniel R. Crooks et al. HUMAN MOLECULAR GENETICS
- Novel locus including FGF21 is associated with dietary macronutrient intake
- (2013) Audrey Y. Chu et al. HUMAN MOLECULAR GENETICS
- Hepatic stellate cells in liver development, regeneration, and cancer
- (2013) Chunyue Yin et al. JOURNAL OF CLINICAL INVESTIGATION
- FGF21 mediates the lipid metabolism response to amino acid starvation
- (2013) Ana Luísa De Sousa-Coelho et al. JOURNAL OF LIPID RESEARCH
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- (2013) Angie L Bookout et al. NATURE MEDICINE
- Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
- (2013) Alexei Kharitonenkov et al. PLoS One
- LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
- (2013) Andrew C. Adams et al. PLoS One
- Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice
- (2013) Xing Xian Yu et al. PLoS One
- De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
- (2013) Leah Eissing et al. Nature Communications
- Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue
- (2013) Shu Q. Liu et al. Scientific Reports
- Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
- (2012) Frank G. Schaap et al. BIOCHIMIE
- Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
- (2012) Hae-Ki Min et al. Cell Metabolism
- Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide
- (2012) M. J. Watt et al. DIABETOLOGIA
- Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis
- (2012) Li Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
- (2012) Hyunsun Jo et al. HEPATOLOGY
- Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)
- (2012) Hai Thi Do et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production
- (2012) Annie-Carole Tosello-Trampont et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
- (2012) Jan Petrasek et al. JOURNAL OF CLINICAL INVESTIGATION
- Dual actions of fibroblast growth factor 19 on lipid metabolism
- (2012) Xinle Wu et al. JOURNAL OF LIPID RESEARCH
- FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
- (2012) Murielle M. Véniant et al. PLoS One
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
- (2012) W. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dyslipidemia in Patients with Nonalcoholic Fatty Liver Disease
- (2012) Hemant Chatrath et al. SEMINARS IN LIVER DISEASE
- The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
- (2012) Yuan Zhang et al. eLife
- Liver Fibrogenesis in Non-Alcoholic Steatohepatitis
- (2012) Zhaolian Bian et al. Frontiers in Physiology
- The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
- (2012) Andrew C. Adams et al. Molecular Metabolism
- Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms
- (2011) Mahnoush S. Shafiei et al. AMERICAN JOURNAL OF PATHOLOGY
- Thiazolidinediones Are Potent Inducers of Fibroblast Growth Factor 21 Expression in the Liver
- (2011) Katsutaka Oishi et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
- (2011) Matthew J. Potthoff et al. Cell Metabolism
- Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid
- (2011) Bee K. Tan et al. DIABETES
- FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
- (2011) J. Mu et al. DIABETES
- Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
- (2011) Fredirick L. Mashili et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo
- (2011) ffolliott M. Fisher et al. ENDOCRINOLOGY
- Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
- (2011) Timea Csak et al. HEPATOLOGY
- Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
- (2011) Cynthia D. Guy et al. HEPATOLOGY
- Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
- (2011) Xuan Ge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased production of sonic hedgehog by ballooned hepatocytes
- (2011) Fatima Rangwala et al. JOURNAL OF PATHOLOGY
- FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways
- (2011) Ai-Luen Wu et al. PLoS One
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
- (2011) Naim Alkhouri et al. Expert Review of Gastroenterology & Hepatology
- Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
- (2010) f. M. Fisher et al. DIABETES
- Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
- (2010) Yusuf Yilmaz et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
- (2010) Jody Dushay et al. GASTROENTEROLOGY
- Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis
- (2010) Hyeyoung Kim Gut and Liver
- Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
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- Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
- (2010) Brent A. Neuschwander-Tetri HEPATOLOGY
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
- (2010) Herbert Tilg et al. HEPATOLOGY
- Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in aPPARα-dependent Manner
- (2010) Andrew C. Adams et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
- (2010) Yuko Akazawa et al. JOURNAL OF HEPATOLOGY
- Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
- (2010) Huating Li et al. JOURNAL OF HEPATOLOGY
- Hedgehog signaling in the liver
- (2010) Alessia Omenetti et al. JOURNAL OF HEPATOLOGY
- Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
- (2010) Klementina Fon Tacer et al. MOLECULAR ENDOCRINOLOGY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
- (2010) Giovanni Targher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile
- (2010) Zhuofeng Lin et al. PLoS One
- Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
- (2010) X. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
- (2009) Motoharu Awazawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
- (2009) Michael B Fessler et al. CURRENT OPINION IN LIPIDOLOGY
- Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
- (2009) Mark P. Mattson EXPERIMENTAL GERONTOLOGY
- Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice
- (2009) Charis L. Johnson et al. GASTROENTEROLOGY
- FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
- (2009) Xinle Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
- (2009) X. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FGF21 induces PGC-1 and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- (2009) M. J. Potthoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis
- (2008) Anna Wieckowska et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- (2008) Cecilia Gälman et al. Cell Metabolism
- UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
- (2008) D. Thomas Rutkowski et al. DEVELOPMENTAL CELL
- Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism
- (2008) L. Qiao et al. DIABETES
- Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
- (2008) X. Zhang et al. DIABETES
- Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
- (2008) J. Xu et al. DIABETES
- Fibroblast Growth Factor 21 Corrects Obesity in Mice
- (2008) Tamer Coskun et al. ENDOCRINOLOGY
- FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity
- (2008) Peter Arner et al. FEBS LETTERS
- Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor and Altered Metabolic States
- (2008) E. S. Muise et al. MOLECULAR PHARMACOLOGY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
- (2007) Puneet Puri et al. GASTROENTEROLOGY
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