FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

(2017) Shanaka Stanislaus et al.   ENDOCRINOLOGY

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

(2016) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates

(2016) W. Clayton Thompson et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Fibroblast growth factor 21 has no direct role in regulating fertility in female mice

(2016) Garima Singhal et al.   Molecular Metabolism

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

(2015) Ricardo J. Samms et al.   Cell Reports

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta)

(2013) E B Nygaard et al.   INTERNATIONAL JOURNAL OF OBESITY

FGF21 contributes to neuroendocrine control of female reproduction

(2013) Bryn M Owen et al.   NATURE MEDICINE

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

(2013) Eric S. Muise et al.   PLoS One

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

(2012) P. Kievit et al.   DIABETES

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate

(2012) Sarah M. Comstock et al.   Molecular Metabolism

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women

(2011) P S Hinton et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Actions and Mode of Actions of FGF19 Subfamily Members

(2008) Seiji FUKUMOTO   ENDOCRINE JOURNAL

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

(2008) Anna Kotronen et al.   GASTROENTEROLOGY

Relationship Between Social Rank and Cortisol and Testosterone Concentrations in Male Cynomolgus Monkeys (Macaca fascicularis)

(2008) P. W. Czoty et al.   JOURNAL OF NEUROENDOCRINOLOGY