NLRP3 inflammasome activation is required for fibrosis development in NAFLD

Fetuin-A mRNA expression is elevated in NASH compared with NAFL patients

(2013) Alisan Kahraman et al.   CLINICAL SCIENCE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

1375 BARIATRIC SURGERY REDUCES ADIPOCYTE SIZE, IMPROVES LIVER INJURY AND COUNTERACTS LIPOTOXICITY VIA CHANGES IN SERUM FATTY ACID COMPOSITION AND ADIPONECTIN LEVELS

(2013) A. Wree et al.   JOURNAL OF HEPATOLOGY

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Management of Nonalcoholic Steatohepatitis

(2012) Suzanne E. Mahady et al.   Clinics in Liver Disease

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

The epidemiology, pathogenesis and histopathology of fatty liver disease

(2012) Adam P Levene et al.   HISTOPATHOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models

(2012) M. D. McGeough et al.   JOURNAL OF IMMUNOLOGY

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

The interaction of hepatic lipid and glucose metabolism in liver diseases

(2011) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Immunodeficiency and Genetic Defects of Pattern-Recognition Receptors

(2011) Mihai G. Netea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes

(2010) Alexander Wree et al.   DIGESTION

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity

(2009) Susannah D. Brydges et al.   IMMUNITY

High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice

(2009) Maaike H. Oosterveer et al.   PLoS One

Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet

(2009) Baukje de Roos et al.   PROTEOMICS

Cautionary insights on knockout mouse studies: The gene or not the gene?

(2008) Amy F. Eisener-Dorman et al.   BRAIN BEHAVIOR AND IMMUNITY