Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner

Changes in beta cell function occur in prediabetes and early disease in the Lepr db mouse model of diabetes

(2016) Oanh H. Do et al.   DIABETOLOGIA

Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis

(2016) Vivek K. Shenoy et al.   PLoS One

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

(2015) Z. Lin et al.   CIRCULATION

 miR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes

(2015) X.Y. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Natural history of β-cell adaptation and failure in type 2 diabetes

(2015) Emilyn U. Alejandro et al.   MOLECULAR ASPECTS OF MEDICINE

FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway

(2014) S. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes

(2014) Elina Hakonen et al.   DIABETOLOGIA

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

(2014) Ffolliott M. Fisher et al.   GASTROENTEROLOGY

Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor-Deficient Mice

(2013) B. A. Omar et al.   DIABETES

High Glucose Represses  -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor   Signaling

(2013) W. Y. So et al.   DIABETES

Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism

(2012) Mark Y. Sun et al.   BIOPHYSICAL JOURNAL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells

(2012) D. Zhu et al.   DIABETOLOGIA

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

FGF21 Requires βklotho to Act In Vivo

(2012) Andrew C. Adams et al.   PLoS One

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Glucose-Dependent Changes in SNARE Protein Levels in Pancreatic β-Cells

(2011) Benjamín Torrejón-Escribano et al.   ENDOCRINOLOGY

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

(2011) Clarence Hale et al.   ENDOCRINOLOGY

Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

(2011) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNARE Conformational Changes that Prepare Vesicles for Exocytosis

(2010) Noriko Takahashi et al.   Cell Metabolism

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

(2010) Kazuma Kaneko et al.   Cell Metabolism

Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus

(2010) Jack L. Leahy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function

(2008) Hideaki KANETO et al.   ENDOCRINE JOURNAL

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS