Apoptosis and necroptosis in the liver: a matter of life and death

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis

(2018) Celine Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

(2018) Bilon Khambu et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance

(2017) Hilal Ahmad Khan et al.   Hepatobiliary & Pancreatic Diseases International

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

Death begets a new beginning

(2017) Lidia Bosurgi et al.   IMMUNOLOGICAL REVIEWS

Necroptotic cell death in anti-cancer therapy

(2017) Olga Krysko et al.   IMMUNOLOGICAL REVIEWS

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

(2017) Sushil Kumar et al.   IMMUNOLOGICAL REVIEWS

Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins

(2017) Lazaros Vasilikos et al.   IMMUNOLOGY AND CELL BIOLOGY

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasomes in Liver Fibrosis

(2017) Fernando Alegre et al.   SEMINARS IN LIVER DISEASE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Treatment options for alcoholic and non-alcoholic fatty liver disease: A review

(2017) Sukhpreet Singh et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis

(2017) Philippe Vasseur et al.   Oncotarget

Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

(2016) Francis A.S. Lee et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability

(2016) G. Mazzolini et al.   CLINICAL SCIENCE

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents

(2016) Spandana Rajendra Kopalli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

(2016) Elena Arriazu et al.   GUT

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1

(2016) Christiane Koppe et al.   HEPATOLOGY

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

(2016) Mei Xiang et al.   JOURNAL OF HEPATOLOGY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis

(2016) Sujith V. W. Weerasinghe et al.   MOLECULAR BIOLOGY OF THE CELL

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

(2016) Aveline Filliol et al.   Cell Death & Disease

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

(2016) Jérémie Gautheron et al.   Nature Communications

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity

(2015) Anne T. Schneider et al.   HEPATOLOGY

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury

(2015) M Deutsch et al.   Cell Death & Disease

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Inflammatory outcomes of apoptosis, necrosis and necroptosis

(2014) Pavel Davidovich et al.   BIOLOGICAL CHEMISTRY

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model

(2014) Samjhana Thapaliya et al.   DIGESTIVE DISEASES AND SCIENCES

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Molecular mechanisms of liver injury: Apoptosis or necrosis

(2014) Kewei Wang   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Necroptosis in Immunity and Ischemia-Reperfusion Injury

(2013) A. Linkermann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Targeting Apoptosis Pathways for New Cancer Therapeutics

(2013) Longchuan Bai et al.   Annual Review of Medicine

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis

(2013) Min-chao Dai et al.   NEUROSCIENCE LETTERS

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

(2013) Diana Panayotova-Dimitrova et al.   Cell Reports

Inflammation and liver tumorigenesis

(2013) Beicheng Sun et al.   Frontiers of Medicine

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib

(2012) Kristin Wahl et al.   HEPATOLOGY

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Hepatocellular Carcinoma Risk Prediction Model for the General Population: The Predictive Power of Transaminases

(2012) Chi-Pang Wen et al.   JNCI-Journal of the National Cancer Institute

A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

(2012) Seamus J. Martin et al.   MOLECULAR CELL

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer

(2011) Christian Liedtke et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score

(2011) Hwai-I Yang et al.   LANCET ONCOLOGY

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Tumor necrosis factor-α accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease

(2010) Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

(2010) Y-T Wu et al.   CELL DEATH AND DIFFERENTIATION

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

An apoptosis panel for nonalcoholic steatohepatitis diagnosis

(2010) Tarek I. Abu-Rajab Tamimi et al.   JOURNAL OF HEPATOLOGY

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Lethal weapons: DAP-kinase, autophagy and cell death

(2009) Shani Bialik et al.   CURRENT OPINION IN CELL BIOLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

(2009) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Caspase activation is associated with spontaneous recovery from acute liver failure

(2008) Xandra Volkmann et al.   HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

(2008) T. Luedde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!

(2008) Yun Fan et al.   TRENDS IN CELL BIOLOGY