A single combination gene therapy treats multiple age-related diseases
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A single combination gene therapy treats multiple age-related diseases
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 47, Pages 23505-23511
Publisher
Proceedings of the National Academy of Sciences
Online
2019-11-05
DOI
10.1073/pnas.1910073116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury
- (2018) Fanghua Li et al. FASEB JOURNAL
- FGF21 acts as a negative regulator of bile acid synthesis
- (2018) Michelle M Chen et al. JOURNAL OF ENDOCRINOLOGY
- The Business of Anti-Aging Science
- (2017) João Pedro de Magalhães et al. TRENDS IN BIOTECHNOLOGY
- Fibroblast growth factor 21 in chronic kidney disease
- (2017) Sahapab Anuwatmatee et al. CLINICA CHIMICA ACTA
- Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice
- (2016) E.A. Forsberg et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Strategies and Challenges in Clinical Trials Targeting Human Aging
- (2016) John C. Newman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
- (2015) Yusuke Joki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Renal Production, Uptake, and Handling of Circulating Klotho
- (2015) M. C. Hu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
- (2015) Christopher E. Wall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ageing and the epidemiology of multimorbidity
- (2014) M. J. Divo et al. EUROPEAN RESPIRATORY JOURNAL
- Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
- (2014) Kristin V.T. Engebretsen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response
- (2014) Jingqi Yan et al. NATURE MEDICINE
- Transforming growth factor beta1 (TGFbeta1) in physiology and pathology
- (2013) Dariusz Kajdaniuk et al. Endokrynologia Polska
- Rejuvenating the ageing heart
- (2013) Alexandra Flemming NATURE REVIEWS DRUG DISCOVERY
- Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
- (2013) A. Planavila et al. Nature Communications
- Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer
- (2012) G. Buchlis et al. BLOOD
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
- (2012) Bruno Bernardes de Jesus et al. EMBO Molecular Medicine
- Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
- (2012) Randy Hecht et al. PLoS One
- Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
- (2012) Jian Xie et al. Nature Communications
- The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
- (2012) Yuan Zhang et al. eLife
- Identification of novel small molecules that elevate Klotho expression
- (2011) Gwendalyn D. King et al. BIOCHEMICAL JOURNAL
- Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling
- (2011) Hariom Yadav et al. Cell Metabolism
- Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
- (2011) Shigehiro Doi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epidemiology and risk profile of heart failure
- (2010) Anh L. Bui et al. Nature Reviews Cardiology
- Transverse Aortic Constriction in Mice
- (2010) Angela C. deAlmeida et al. Jove-Journal of Visualized Experiments
- Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
- (2009) Robert L. Chevalier et al. KIDNEY INTERNATIONAL
- Gene Therapy Using Adeno-Associated Virus Vectors
- (2008) S. Daya et al. CLINICAL MICROBIOLOGY REVIEWS
- Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
- (2008) E. M. Zeisberg et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection
- (2008) Carmela Zincarelli et al. MOLECULAR THERAPY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started