Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's diseasein vitromodel

(2016) Mijung Lee et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

β-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes

(2016) Jin-Sun Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melanogenesis inhibition of β-lapachone, a natural product from Tabebuia avellanedae, with effective in vivo lightening potency

(2015) Jin Hee Kim et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells

(2015) Jing Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

(2015) Eun-Jung Lee et al.   Journal of Neuroinflammation

Transcriptional dysregulation in Huntington’s disease: The role of histone deacetylases

(2015) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

(2015) Z Moore et al.   Cell Death & Disease

Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington’s disease R6/2 model

(2015) Wooseok Im et al.   Scientific Reports

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

β-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains

(2013) L. Macedo et al.   PHYTOMEDICINE

Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy

(2013) Bae Hyun Shin et al.   PLoS One

Sirtuins: Common Targets in Aging and in Neurodegeneration

(2012) Rita Machado de Oliveira et al.   CURRENT DRUG TARGETS

Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone)

(2012) Marília Maria Sitônio et al.   INFLAMMATION RESEARCH

Finding a sirtuin truth in Huntington's disease

(2012) Albert R La Spada   NATURE MEDICINE

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

(2012) Jeong-sook Lee et al.   PLoS One

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome

(2011) Chrystian Junqueira Alves et al.   BRAIN RESEARCH

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells

(2010) Eun Jung Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In vitro and in vivo wound healing-promoting activities of β-lapachone

(2008) Hsiu-Ni Kung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY